TRIM8-associated non-coding RNA panel as a biomarker for Lupus nephritis activity
Background Lupus nephritis (LN) represents a major complication in systemic lupus erythematosus (SLE). The objective of this study was to evaluate the TRIM8 gene and its associated non-coding RNAs ( lnc-SSBP2-1:1 and hsa-miR-126-5p ) as potential non-invasive biomarkers for LN activity. Methods Bioi...
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| Published in: | Journal of translational medicine Vol. 23; no. 1; pp. 1229 - 10 |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
London
BioMed Central
05.11.2025
BioMed Central Ltd BMC |
| Subjects: | |
| ISSN: | 1479-5876, 1479-5876 |
| Online Access: | Get full text |
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| Abstract | Background
Lupus nephritis (LN) represents a major complication in systemic lupus erythematosus (SLE). The objective of this study was to evaluate the
TRIM8
gene and its associated non-coding RNAs (
lnc-SSBP2-1:1
and
hsa-miR-126-5p
) as potential non-invasive biomarkers for LN activity.
Methods
Bioinformatics analyses were initially employed to identify candidate mRNA and associated non-coding RNAs (ncRNAs) implicated in LN. Expression profiles of
TRIM8lnc-SSBP2-1:1
and
hsa-miR-126-5p
were validated in blood samples from 40 active LN, 30 inactive LN patients, and 20 healthy individuals via real-time PCR.
Results
TRIM8
mRNA and
lnc-SSBP2-1:1
lncRNA levels were notably upregulated in active LN (
p
< 0.001), while
hsa-miR-126-5p
was reduced (
p
< 0.001). SLEDAI-2K scores correlated positively with
TRIM8
mRNA and
lnc-SSBP2-1:1
, and negatively with
hsa-miR-126-5p
.
Conclusions
This study highlights
TRIM8
-associated ncRNA regulatory network as promising biomarkers in LN activωity, with potential clinical impact.
Graphical abstract
Highlights
TRIM8
and
lnc-SSBP2-1:1
are upregulated,
hsa-miR-126-5p
is downregulated in active LN
Biomarkers strongly correlated with SLEDAI-2K disease activity scores
High diagnostic accuracy (AUCs > 0.93) in distinguishing active vs inactive LN
Potential non-invasive tool to complement current LN monitoring |
|---|---|
| AbstractList | Lupus nephritis (LN) represents a major complication in systemic lupus erythematosus (SLE). The objective of this study was to evaluate the TRIM8 gene and its associated non-coding RNAs (lnc-SSBP2-1:1 and hsa-miR-126-5p) as potential non-invasive biomarkers for LN activity.BACKGROUNDLupus nephritis (LN) represents a major complication in systemic lupus erythematosus (SLE). The objective of this study was to evaluate the TRIM8 gene and its associated non-coding RNAs (lnc-SSBP2-1:1 and hsa-miR-126-5p) as potential non-invasive biomarkers for LN activity.Bioinformatics analyses were initially employed to identify candidate mRNA and associated non-coding RNAs (ncRNAs) implicated in LN. Expression profiles of TRIM8lnc-SSBP2-1:1and hsa-miR-126-5p were validated in blood samples from 40 active LN, 30 inactive LN patients, and 20 healthy individuals via real-time PCR.METHODSBioinformatics analyses were initially employed to identify candidate mRNA and associated non-coding RNAs (ncRNAs) implicated in LN. Expression profiles of TRIM8lnc-SSBP2-1:1and hsa-miR-126-5p were validated in blood samples from 40 active LN, 30 inactive LN patients, and 20 healthy individuals via real-time PCR.TRIM8 mRNA and lnc-SSBP2-1:1 lncRNA levels were notably upregulated in active LN (p < 0.001), while hsa-miR-126-5p was reduced (p < 0.001). SLEDAI-2K scores correlated positively with TRIM8 mRNA and lnc-SSBP2-1:1, and negatively with hsa-miR-126-5p.RESULTSTRIM8 mRNA and lnc-SSBP2-1:1 lncRNA levels were notably upregulated in active LN (p < 0.001), while hsa-miR-126-5p was reduced (p < 0.001). SLEDAI-2K scores correlated positively with TRIM8 mRNA and lnc-SSBP2-1:1, and negatively with hsa-miR-126-5p.This study highlights TRIM8-associated ncRNA regulatory network as promising biomarkers in LN activωity, with potential clinical impact.CONCLUSIONSThis study highlights TRIM8-associated ncRNA regulatory network as promising biomarkers in LN activωity, with potential clinical impact. Abstract Background Lupus nephritis (LN) represents a major complication in systemic lupus erythematosus (SLE). The objective of this study was to evaluate the TRIM8 gene and its associated non-coding RNAs (lnc-SSBP2-1:1 and hsa-miR-126-5p) as potential non-invasive biomarkers for LN activity. Methods Bioinformatics analyses were initially employed to identify candidate mRNA and associated non-coding RNAs (ncRNAs) implicated in LN. Expression profiles of TRIM8lnc-SSBP2-1:1and hsa-miR-126-5p were validated in blood samples from 40 active LN, 30 inactive LN patients, and 20 healthy individuals via real-time PCR. Results TRIM8 mRNA and lnc-SSBP2-1:1 lncRNA levels were notably upregulated in active LN (p < 0.001), while hsa-miR-126-5p was reduced (p < 0.001). SLEDAI-2K scores correlated positively with TRIM8 mRNA and lnc-SSBP2-1:1, and negatively with hsa-miR-126-5p. Conclusions This study highlights TRIM8-associated ncRNA regulatory network as promising biomarkers in LN activωity, with potential clinical impact. Graphical abstract Background Lupus nephritis (LN) represents a major complication in systemic lupus erythematosus (SLE). The objective of this study was to evaluate the TRIM8 gene and its associated non-coding RNAs (lnc-SSBP2-1:1 and hsa-miR-126-5p) as potential non-invasive biomarkers for LN activity. Methods Bioinformatics analyses were initially employed to identify candidate mRNA and associated non-coding RNAs (ncRNAs) implicated in LN. Expression profiles of TRIM8lnc-SSBP2-1:1and hsa-miR-126-5p were validated in blood samples from 40 active LN, 30 inactive LN patients, and 20 healthy individuals via real-time PCR. Results TRIM8 mRNA and lnc-SSBP2-1:1 lncRNA levels were notably upregulated in active LN (p < 0.001), while hsa-miR-126-5p was reduced (p < 0.001). SLEDAI-2K scores correlated positively with TRIM8 mRNA and lnc-SSBP2-1:1, and negatively with hsa-miR-126-5p. Conclusions This study highlights TRIM8-associated ncRNA regulatory network as promising biomarkers in LN activ[omega]ity, with potential clinical impact. Graphical abstract Keywords: Lupus nephritis, TRIM8, hsa-miR-126-5p, lnc-SSBP2-1:1, non-coding RNA network, Biomarkers, Disease activity Lupus nephritis (LN) represents a major complication in systemic lupus erythematosus (SLE). The objective of this study was to evaluate the TRIM8 gene and its associated non-coding RNAs (lnc-SSBP2-1:1 and hsa-miR-126-5p) as potential non-invasive biomarkers for LN activity. Bioinformatics analyses were initially employed to identify candidate mRNA and associated non-coding RNAs (ncRNAs) implicated in LN. Expression profiles of TRIM8lnc-SSBP2-1:1and hsa-miR-126-5p were validated in blood samples from 40 active LN, 30 inactive LN patients, and 20 healthy individuals via real-time PCR. TRIM8 mRNA and lnc-SSBP2-1:1 lncRNA levels were notably upregulated in active LN (p < 0.001), while hsa-miR-126-5p was reduced (p < 0.001). SLEDAI-2K scores correlated positively with TRIM8 mRNA and lnc-SSBP2-1:1, and negatively with hsa-miR-126-5p. This study highlights TRIM8-associated ncRNA regulatory network as promising biomarkers in LN activ[omega]ity, with potential clinical impact. Lupus nephritis (LN) represents a major complication in systemic lupus erythematosus (SLE). The objective of this study was to evaluate the TRIM8 gene and its associated non-coding RNAs (lnc-SSBP2-1:1 and hsa-miR-126-5p) as potential non-invasive biomarkers for LN activity. Bioinformatics analyses were initially employed to identify candidate mRNA and associated non-coding RNAs (ncRNAs) implicated in LN. Expression profiles of TRIM8lnc-SSBP2-1:1and hsa-miR-126-5p were validated in blood samples from 40 active LN, 30 inactive LN patients, and 20 healthy individuals via real-time PCR. TRIM8 mRNA and lnc-SSBP2-1:1 lncRNA levels were notably upregulated in active LN (p < 0.001), while hsa-miR-126-5p was reduced (p < 0.001). SLEDAI-2K scores correlated positively with TRIM8 mRNA and lnc-SSBP2-1:1, and negatively with hsa-miR-126-5p. This study highlights TRIM8-associated ncRNA regulatory network as promising biomarkers in LN activωity, with potential clinical impact. Background Lupus nephritis (LN) represents a major complication in systemic lupus erythematosus (SLE). The objective of this study was to evaluate the TRIM8 gene and its associated non-coding RNAs ( lnc-SSBP2-1:1 and hsa-miR-126-5p ) as potential non-invasive biomarkers for LN activity. Methods Bioinformatics analyses were initially employed to identify candidate mRNA and associated non-coding RNAs (ncRNAs) implicated in LN. Expression profiles of TRIM8lnc-SSBP2-1:1 and hsa-miR-126-5p were validated in blood samples from 40 active LN, 30 inactive LN patients, and 20 healthy individuals via real-time PCR. Results TRIM8 mRNA and lnc-SSBP2-1:1 lncRNA levels were notably upregulated in active LN ( p < 0.001), while hsa-miR-126-5p was reduced ( p < 0.001). SLEDAI-2K scores correlated positively with TRIM8 mRNA and lnc-SSBP2-1:1 , and negatively with hsa-miR-126-5p . Conclusions This study highlights TRIM8 -associated ncRNA regulatory network as promising biomarkers in LN activωity, with potential clinical impact. Graphical abstract Highlights TRIM8 and lnc-SSBP2-1:1 are upregulated, hsa-miR-126-5p is downregulated in active LN Biomarkers strongly correlated with SLEDAI-2K disease activity scores High diagnostic accuracy (AUCs > 0.93) in distinguishing active vs inactive LN Potential non-invasive tool to complement current LN monitoring |
| ArticleNumber | 1229 |
| Audience | Academic |
| Author | Kamel, Marwa Mostafa Eissa, Sanaa Kamel, Cherry Reda Shinnawy, Howayda Abdelhamid El Ali, Nouran Abdelfattah Sayed Elgawad, Mostafa Abdelnasier Abd Behairy, Maha Abdelmoneim |
| Author_xml | – sequence: 1 givenname: Mostafa Abdelnasier Abd orcidid: 0000-0001-5525-556X surname: Elgawad fullname: Elgawad, Mostafa Abdelnasier Abd organization: Internal Medicine and Nephrology Department, Faculty of Medicine, Ain Shams University – sequence: 2 givenname: Howayda Abdelhamid El orcidid: 0009-0007-6487-3301 surname: Shinnawy fullname: Shinnawy, Howayda Abdelhamid El organization: Internal Medicine and Nephrology Department, Faculty of Medicine, Ain Shams University – sequence: 3 givenname: Sanaa orcidid: 0000-0001-8591-3244 surname: Eissa fullname: Eissa, Sanaa email: drsanaa_mohamed@med.asu.edu.eg organization: Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Ain Shams University – sequence: 4 givenname: Nouran Abdelfattah Sayed orcidid: 0009-0005-8537-876X surname: Ali fullname: Ali, Nouran Abdelfattah Sayed organization: Internal Medicine and Nephrology Department, Faculty of Medicine, Ain Shams University – sequence: 5 givenname: Maha Abdelmoneim orcidid: 0000-0002-2543-3932 surname: Behairy fullname: Behairy, Maha Abdelmoneim organization: Internal Medicine and Nephrology Department, Faculty of Medicine, Ain Shams University – sequence: 6 givenname: Cherry Reda orcidid: 0000-0001-9698-0303 surname: Kamel fullname: Kamel, Cherry Reda organization: Internal Medicine and Nephrology Department, Faculty of Medicine, Ain Shams University – sequence: 7 givenname: Marwa Mostafa orcidid: 0000-0001-5622-0887 surname: Kamel fullname: Kamel, Marwa Mostafa organization: Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Ain Shams University |
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| Keywords | Biomarkers Disease activity Lupus nephritis non-coding RNA network TRIM8 hsa-miR-126-5p lnc-SSBP2-1:1 |
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Lupus nephritis (LN) represents a major complication in systemic lupus erythematosus (SLE). The objective of this study was to evaluate the
TRIM8... Lupus nephritis (LN) represents a major complication in systemic lupus erythematosus (SLE). The objective of this study was to evaluate the TRIM8 gene and its... Background Lupus nephritis (LN) represents a major complication in systemic lupus erythematosus (SLE). The objective of this study was to evaluate the TRIM8... Abstract Background Lupus nephritis (LN) represents a major complication in systemic lupus erythematosus (SLE). The objective of this study was to evaluate the... |
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| SubjectTerms | Adult Analysis B cells Biological markers Biomarkers Biomarkers - blood Biomarkers - metabolism Biomedical and Life Sciences Biomedicine Care and treatment Carrier Proteins - genetics Carrier Proteins - metabolism Case-Control Studies Complications and side effects Development and progression Diagnosis Ethylenediaminetetraacetic acid Female hsa-miR-126-5p Humans Immune response Immunobiology and immunotherapy lnc-SSBP2-1:1 Lupus Lupus nephritis Lupus Nephritis - blood Lupus Nephritis - genetics Male Medicine/Public Health MicroRNAs - genetics MicroRNAs - metabolism Middle Aged Nephritis Nerve Tissue Proteins non-coding RNA network Polymerase chain reaction Risk factors RNA RNA, Long Noncoding - genetics RNA, Messenger - genetics RNA, Messenger - metabolism RNA, Untranslated - genetics RNA, Untranslated - metabolism Systemic lupus erythematosus Testing TRIM8 Tripartite Motif Proteins |
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| Title | TRIM8-associated non-coding RNA panel as a biomarker for Lupus nephritis activity |
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