Cooperative binding of AP-1 and TEAD4 modulates the balance between vascular smooth muscle and hemogenic cell fate

The transmission of extracellular signals into the nucleus involves inducible transcription factors, but how different signalling pathways act in a cell type-specific fashion is poorly understood. Here, we studied the regulatory role of the AP-1 transcription factor family in blood development using...

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Veröffentlicht in:	Development (Cambridge) Jg. 143; H. 23; S. 4324
Hauptverfasser:	Obier, Nadine, Cauchy, Pierre, Assi, Salam A, Gilmour, Jane, Lie-A-Ling, Michael, Lichtinger, Monika, Hoogenkamp, Maarten, Noailles, Laura, Cockerill, Peter N, Lacaud, Georges, Kouskoff, Valerie, Bonifer, Constanze
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England 01.12.2016
Schlagworte:	Activating Transcription Factors - metabolism Animals Binding Sites - genetics Cell Differentiation - physiology Cell Line DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Embryonic Stem Cells - cytology Gene Expression - genetics Gene Expression Profiling Mice Muscle Proteins - metabolism Muscle, Smooth, Vascular - cytology Muscle, Smooth, Vascular - metabolism Protein Binding Proto-Oncogene Proteins c-fos - metabolism Proto-Oncogene Proteins c-jun - metabolism Signal Transduction - physiology TEA Domain Transcription Factors Transcription Factor AP-1 - antagonists & inhibitors Transcription Factor AP-1 - metabolism Transcription Factors - metabolism TEAD4 ESC differentiation Signalling hubs Hematopoietic specification AP-1 Hippo signalling
ISSN:	1477-9129, 1477-9129
Online-Zugang:	Weitere Angaben
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