Treatment of Invasive Brain Tumors Using a Chain-like Nanoparticle

Glioblastoma multiforme is generally recalcitrant to current surgical and local radiotherapeutic approaches. Moreover, systemic chemotherapeutic approaches are impeded by the blood-tumor barrier. To circumvent limitations in the latter area, we developed a multicomponent, chain-like nanoparticle tha...

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Bibliographic Details
Published in:	Cancer research (Chicago, Ill.) Vol. 75; no. 7; p. 1356
Main Authors:	Peiris, Pubudu M, Abramowski, Aaron, Mcginnity, James, Doolittle, Elizabeth, Toy, Randall, Gopalakrishnan, Ramamurthy, Shah, Shruti, Bauer, Lisa, Ghaghada, Ketan B, Hoimes, Christopher, Brady-Kalnay, Susann M, Basilion, James P, Griswold, Mark A, Karathanasis, Efstathios
Format:	Journal Article
Language:	English
Published:	United States 01.04.2015
Subjects:	Animals Antineoplastic Agents - administration & dosage Antineoplastic Agents - chemistry Blood-Brain Barrier Brain Neoplasms - drug therapy Brain Neoplasms - metabolism Brain Neoplasms - pathology Doxorubicin - administration & dosage Drug Carriers - administration & dosage Drug Carriers - chemistry Ferric Compounds - chemistry Glioblastoma - drug therapy Glioblastoma - metabolism Glioblastoma - pathology Integrin alphaVbeta3 - metabolism Mice, Nude Nanoparticles - chemistry Neoplasm Invasiveness Xenograft Model Antitumor Assays
ISSN:	1538-7445, 1538-7445
Online Access:	Get more information
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