Targeting c-MYC in Platinum-Resistant Ovarian Cancer

The purpose of this study was to investigate the molecular and therapeutic effects of siRNA-mediated c-MYC silencing in cisplatin-resistant ovarian cancer. Statistical analysis of patient's data extracted from The Cancer Genome Atlas (TCGA) portal showed that the disease-free (DFS) and the over...

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Veröffentlicht in:	Molecular cancer therapeutics Jg. 14; H. 10; S. 2260
Hauptverfasser:	Reyes-González, Jeyshka M, Armaiz-Peña, Guillermo N, Mangala, Lingegowda S, Valiyeva, Fatma, Ivan, Cristina, Pradeep, Sunila, Echevarría-Vargas, Ileabett M, Rivera-Reyes, Adrian, Sood, Anil K, Vivas-Mejía, Pablo E
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.10.2015
Schlagworte:	Animals Antineoplastic Agents - pharmacology Apoptosis Cell Line, Tumor Cell Survival Cisplatin - pharmacology Disease-Free Survival Drug Resistance, Neoplasm Female Gene Expression Gene Knockdown Techniques Humans Kaplan-Meier Estimate Mice, Nude Ovarian Neoplasms - drug therapy Ovarian Neoplasms - mortality Proto-Oncogene Proteins c-myc - genetics Proto-Oncogene Proteins c-myc - metabolism RNA, Small Interfering - genetics Xenograft Model Antitumor Assays
ISSN:	1538-8514, 1538-8514
Online-Zugang:	Weitere Angaben
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