Peritoneal Spread of Ovarian Cancer Harbors Therapeutic Vulnerabilities Regulated by FOXM1 and EGFR/ERBB2 Signaling

Peritoneal spread is the primary mechanism of metastasis of ovarian cancer, and survival of ovarian cancer cells in the peritoneal cavity as nonadherent spheroids and their adherence to the mesothelium of distant organs lead to cancer progression, metastasis, and mortality. However, the mechanisms t...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Jg. 80; H. 24; S. 5554
Hauptverfasser:	Parashar, Deepak, Nair, Bindu, Geethadevi, Anjali, George, Jasmine, Nair, Ajay, Tsaih, Shirng-Wern, Kadamberi, Ishaque P, Gopinadhan Nair, Gopa Kumar, Lu, Yiling, Ramchandran, Ramani, Uyar, Denise S, Rader, Janet S, Ram, Prahlad T, Mills, Gordon B, Pradeep, Sunila, Chaluvally-Raghavan, Pradeep
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 15.12.2020
Schlagworte:	Animals Cell Line, Tumor Cell Proliferation - drug effects Cell Proliferation - genetics Cell Survival - drug effects Cell Survival - genetics Disease Models, Animal ErbB Receptors - antagonists & inhibitors ErbB Receptors - genetics ErbB Receptors - metabolism Female Forkhead Box Protein M1 - antagonists & inhibitors Forkhead Box Protein M1 - genetics Forkhead Box Protein M1 - metabolism Gene Knockdown Techniques Humans Lapatinib - pharmacology Lapatinib - therapeutic use Mice Ovarian Neoplasms - metabolism Ovarian Neoplasms - pathology Peritoneal Neoplasms - metabolism Peritoneal Neoplasms - prevention & control Peritoneal Neoplasms - secondary Receptor, ErbB-2 - antagonists & inhibitors Receptor, ErbB-2 - genetics Receptor, ErbB-2 - metabolism Signal Transduction - drug effects Signal Transduction - genetics Thiostrepton - pharmacology Thiostrepton - therapeutic use Transfection
ISSN:	1538-7445, 1538-7445
Online-Zugang:	Weitere Angaben
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