The Role of Surface Nanotopography and Chemistry on Primary Neutrophil and Macrophage Cellular Responses

Synthetic materials employed for enhancing, replacing, or restoring biological functionality may be compromised by the host immune responses that they evoke. Surface modification has attracted substantial attention as a tool to modulate the host response to synthetic materials; however, how surface...

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Vydané v:	Advanced healthcare materials Ročník 5; číslo 8; s. 956 - 965
Hlavní autori:	Christo, Susan N., Bachhuka, Akash, Diener, Kerrilyn R., Mierczynska, Agnieszka, Hayball, John D., Vasilev, Krasimir
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Germany Blackwell Publishing Ltd 20.04.2016 Wiley Subscription Services, Inc
Predmet:	Acids - pharmacology Amines Animals Cell Line Cells, Cultured Control surfaces Cytokines - secretion Effectors immunomodulation Inflammation Mediators - metabolism Lead (metal) Macrophages Macrophages - drug effects Matrix Metalloproteinase 9 - biosynthesis Mice, Inbred C57BL Microscopy, Atomic Force Nanoparticles Nanoparticles - chemistry Nanostructure Nanotechnology - methods Neutrophil Activation Neutrophils Neutrophils - cytology Photoelectron Spectroscopy surface chemistries Surface chemistry surface nanotopographies Surface Properties Synthetic products T cell receptors immunomodulation macrophages surface nanotopographies neutrophils surface chemistries
ISSN:	2192-2640, 2192-2659, 2192-2659
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Abstract	Synthetic materials employed for enhancing, replacing, or restoring biological functionality may be compromised by the host immune responses that they evoke. Surface modification has attracted substantial attention as a tool to modulate the host response to synthetic materials; however, how surface nanotopography combined with chemistry affects immune effector cell responses is still poorly understood. To address this open question, a unique set of model surfaces with controlled surface nanotopography in the range of 16, 38, and 68 nm has been generated. Tailored outermost surface chemistry that was amine, carboxyl, or methyl group rich has been provided. The combinations of these properties yield 12 surface types that are subject to functional assays assessing key immune effector cells, namely, primary neutrophil and macrophage responses in vitro. The data demonstrate that surface nanotopography leads to enhanced matrix metalloproteinase‐9 production from primary neutrophils, and a decrease in pro‐inflammatory cytokine secretion from primary macrophages. Together, these results are the first to directly compare the immunomodulatory effects of the cooperative interplay between surface nanotopography and chemistry. Innate immune effector cells can differentially respond to the controlled surface nanotopography in the range of 16, 38, and 68 nm. Additional overcoating of these surfaces with amine, carboxyl, or methyl group rich chemistries demonstrates that surfaces with hydrophillic anionic overcoated 68 nm gold nanoparticles can modulate neutrophil and macrophage functionality.
AbstractList	Synthetic materials employed for enhancing, replacing, or restoring biological functionality may be compromised by the host immune responses that they evoke. Surface modification has attracted substantial attention as a tool to modulate the host response to synthetic materials; however, how surface nanotopography combined with chemistry affects immune effector cell responses is still poorly understood. To address this open question, a unique set of model surfaces with controlled surface nanotopography in the range of 16, 38, and 68 nm has been generated. Tailored outermost surface chemistry that was amine, carboxyl, or methyl group rich has been provided. The combinations of these properties yield 12 surface types that are subject to functional assays assessing key immune effector cells, namely, primary neutrophil and macrophage responses in vitro. The data demonstrate that surface nanotopography leads to enhanced matrix metalloproteinase-9 production from primary neutrophils, and a decrease in pro-inflammatory cytokine secretion from primary macrophages. Together, these results are the first to directly compare the immunomodulatory effects of the cooperative interplay between surface nanotopography and chemistry. Innate immune effector cells can differentially respond to the controlled surface nanotopography in the range of 16, 38, and 68 nm. Additional overcoating of these surfaces with amine, carboxyl, or methyl group rich chemistries demonstrates that surfaces with hydrophillic anionic overcoated 68 nm gold nanoparticles can modulate neutrophil and macrophage functionality. Synthetic materials employed for enhancing, replacing, or restoring biological functionality may be compromised by the host immune responses that they evoke. Surface modification has attracted substantial attention as a tool to modulate the host response to synthetic materials; however, how surface nanotopography combined with chemistry affects immune effector cell responses is still poorly understood. To address this open question, a unique set of model surfaces with controlled surface nanotopography in the range of 16, 38, and 68 nm has been generated. Tailored outermost surface chemistry that was amine, carboxyl, or methyl group rich has been provided. The combinations of these properties yield 12 surface types that are subject to functional assays assessing key immune effector cells, namely, primary neutrophil and macrophage responses in vitro. The data demonstrate that surface nanotopography leads to enhanced matrix metalloproteinase-9 production from primary neutrophils, and a decrease in pro-inflammatory cytokine secretion from primary macrophages. Together, these results are the first to directly compare the immunomodulatory effects of the cooperative interplay between surface nanotopography and chemistry. Synthetic materials employed for enhancing, replacing, or restoring biological functionality may be compromised by the host immune responses that they evoke. Surface modification has attracted substantial attention as a tool to modulate the host response to synthetic materials; however, how surface nanotopography combined with chemistry affects immune effector cell responses is still poorly understood. To address this open question, a unique set of model surfaces with controlled surface nanotopography in the range of 16, 38, and 68 nm has been generated. Tailored outermost surface chemistry that was amine, carboxyl, or methyl group rich has been provided. The combinations of these properties yield 12 surface types that are subject to functional assays assessing key immune effector cells, namely, primary neutrophil and macrophage responses in vitro. The data demonstrate that surface nanotopography leads to enhanced matrix metalloproteinase-9 production from primary neutrophils, and a decrease in pro-inflammatory cytokine secretion from primary macrophages. Together, these results are the first to directly compare the immunomodulatory effects of the cooperative interplay between surface nanotopography and chemistry.Synthetic materials employed for enhancing, replacing, or restoring biological functionality may be compromised by the host immune responses that they evoke. Surface modification has attracted substantial attention as a tool to modulate the host response to synthetic materials; however, how surface nanotopography combined with chemistry affects immune effector cell responses is still poorly understood. To address this open question, a unique set of model surfaces with controlled surface nanotopography in the range of 16, 38, and 68 nm has been generated. Tailored outermost surface chemistry that was amine, carboxyl, or methyl group rich has been provided. The combinations of these properties yield 12 surface types that are subject to functional assays assessing key immune effector cells, namely, primary neutrophil and macrophage responses in vitro. The data demonstrate that surface nanotopography leads to enhanced matrix metalloproteinase-9 production from primary neutrophils, and a decrease in pro-inflammatory cytokine secretion from primary macrophages. Together, these results are the first to directly compare the immunomodulatory effects of the cooperative interplay between surface nanotopography and chemistry. Synthetic materials employed for enhancing, replacing, or restoring biological functionality may be compromised by the host immune responses that they evoke. Surface modification has attracted substantial attention as a tool to modulate the host response to synthetic materials; however, how surface nanotopography combined with chemistry affects immune effector cell responses is still poorly understood. To address this open question, a unique set of model surfaces with controlled surface nanotopography in the range of 16, 38, and 68 nm has been generated. Tailored outermost surface chemistry that was amine, carboxyl, or methyl group rich has been provided. The combinations of these properties yield 12 surface types that are subject to functional assays assessing key immune effector cells, namely, primary neutrophil and macrophage responses in vitro. The data demonstrate that surface nanotopography leads to enhanced matrix metalloproteinase‐9 production from primary neutrophils, and a decrease in pro‐inflammatory cytokine secretion from primary macrophages. Together, these results are the first to directly compare the immunomodulatory effects of the cooperative interplay between surface nanotopography and chemistry. Innate immune effector cells can differentially respond to the controlled surface nanotopography in the range of 16, 38, and 68 nm. Additional overcoating of these surfaces with amine, carboxyl, or methyl group rich chemistries demonstrates that surfaces with hydrophillic anionic overcoated 68 nm gold nanoparticles can modulate neutrophil and macrophage functionality.
Author	Mierczynska, Agnieszka Bachhuka, Akash Vasilev, Krasimir Hayball, John D. Diener, Kerrilyn R. Christo, Susan N.
Author_xml	– sequence: 1 givenname: Susan N. surname: Christo fullname: Christo, Susan N. organization: Experimental Therapeutics Laboratory, Sansom Institute and Hanson Institute, School of Pharmacy and Medical Science, University of South Australia, SA, 5000, Adelaide, Australia – sequence: 2 givenname: Akash surname: Bachhuka fullname: Bachhuka, Akash organization: Mawson Institute, University of South Australia, SA, 5095, Adelaide, Australia – sequence: 3 givenname: Kerrilyn R. surname: Diener fullname: Diener, Kerrilyn R. organization: Experimental Therapeutics Laboratory, Sansom Institute and Hanson Institute, School of Pharmacy and Medical Science, University of South Australia, 5000, Adelaide, SA, Australia – sequence: 4 givenname: Agnieszka surname: Mierczynska fullname: Mierczynska, Agnieszka organization: Australian Wine Research Institute, SA, 5064, Adelaide, Australia – sequence: 5 givenname: John D. surname: Hayball fullname: Hayball, John D. email: John.Hayball@unisa.edu.au organization: Experimental Therapeutics Laboratory, Sansom Institute and Hanson Institute, School of Pharmacy and Medical Science, University of South Australia, 5000, Adelaide, SA, Australia – sequence: 6 givenname: Krasimir surname: Vasilev fullname: Vasilev, Krasimir email: John.Hayball@unisa.edu.au organization: Mawson Institute, University of South Australia, SA, 5095, Adelaide, Australia
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/26845244$$D View this record in MEDLINE/PubMed
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Snippet	Synthetic materials employed for enhancing, replacing, or restoring biological functionality may be compromised by the host immune responses that they evoke....
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SubjectTerms	Acids - pharmacology Amines Animals Cell Line Cells, Cultured Control surfaces Cytokines - secretion Effectors immunomodulation Inflammation Mediators - metabolism Lead (metal) Macrophages Macrophages - drug effects Matrix Metalloproteinase 9 - biosynthesis Mice, Inbred C57BL Microscopy, Atomic Force Nanoparticles Nanoparticles - chemistry Nanostructure Nanotechnology - methods Neutrophil Activation Neutrophils Neutrophils - cytology Photoelectron Spectroscopy surface chemistries Surface chemistry surface nanotopographies Surface Properties Synthetic products T cell receptors
Title	The Role of Surface Nanotopography and Chemistry on Primary Neutrophil and Macrophage Cellular Responses
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