Systematic review: The gut microbiota as a link between colorectal cancer and obesity

Summary Microbiome modulation is one of the novel strategies in medicine with the greatest future to improve the health of individuals and reduce the risk of different conditions, including metabolic, immune, inflammatory, and degenerative diseases, as well as cancer. Regarding the latter, many stud...

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Veröffentlicht in:Obesity reviews Jg. 26; H. 4; S. e13872 - n/a
Hauptverfasser: Ruiz‐Malagón, Antonio Jesús, Rodríguez‐Sojo, María Jesús, Redondo, Eduardo, Rodríguez‐Cabezas, María Elena, Gálvez, Julio, Rodríguez‐Nogales, Alba
Format: Journal Article
Sprache:Englisch
Veröffentlicht: England Wiley Subscription Services, Inc 01.04.2025
John Wiley and Sons Inc
Schlagworte:
Animals
Cancer
Carcinogenesis
Carcinogens
colitis
Colorectal cancer
Colorectal carcinoma
colorectal neoplasms
Colorectal Neoplasms - etiology
Colorectal Neoplasms - microbiology
Digestive system
Dysbacteriosis
dysbiosis
Dysbiosis - complications
Energy metabolism
Gastrointestinal Microbiome - physiology
Gastrointestinal tract
Gut microbiota
Health risks
Humans
inflammation
Intestinal microflora
intestinal microorganisms
medicine
Metabolism
mice
microbiome
Microbiomes
Microbiota
Microorganisms
Obesity
Obesity - complications
Obesity - microbiology
Pathogenesis
Review
risk
Risk Factors
risk reduction
Systematic review
microbiota
colitis
colorectal cancer
obesity
ISSN:1467-7881, 1467-789X, 1467-789X
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Abstract Summary Microbiome modulation is one of the novel strategies in medicine with the greatest future to improve the health of individuals and reduce the risk of different conditions, including metabolic, immune, inflammatory, and degenerative diseases, as well as cancer. Regarding the latter, many studies have reported the role of the gut microbiome in carcinogenesis, formation and progression of colorectal cancer (CRC), as well as its response to different systemic therapies. Likewise, obesity, one of the most important risk factors for CRC, is also well known for its association with gut dysbiosis. Moreover, obesity and CRC display, apart from microbial dysbiosis, chronic inflammation, which participates in their pathogenesis. Although human and murine studies demonstrate the significant impact of the microbiome in regulating energy metabolism and CRC development, little is understood about the contribution of the microbiome to the development of obesity‐associated CRC. Therefore, this systematic review explores the evidence for microbiome changes associated with these conditions and hypothesizes that this may contribute to the pathogenesis of obesity‐related CRC. Two databases were searched, and different studies on the relationship among obesity, intestinal microbiota and CRC in clinical and preclinical models were selected. Data extraction was carried out by two reviewers independently, and 101 studies were finally considered. Findings indicate the existence of a risk association between obesity and CRC derived from metabolic, immune, and microbial disorders.
AbstractList Microbiome modulation is one of the novel strategies in medicine with the greatest future to improve the health of individuals and reduce the risk of different conditions, including metabolic, immune, inflammatory, and degenerative diseases, as well as cancer. Regarding the latter, many studies have reported the role of the gut microbiome in carcinogenesis, formation and progression of colorectal cancer (CRC), as well as its response to different systemic therapies. Likewise, obesity, one of the most important risk factors for CRC, is also well known for its association with gut dysbiosis. Moreover, obesity and CRC display, apart from microbial dysbiosis, chronic inflammation, which participates in their pathogenesis. Although human and murine studies demonstrate the significant impact of the microbiome in regulating energy metabolism and CRC development, little is understood about the contribution of the microbiome to the development of obesity‐associated CRC. Therefore, this systematic review explores the evidence for microbiome changes associated with these conditions and hypothesizes that this may contribute to the pathogenesis of obesity‐related CRC. Two databases were searched, and different studies on the relationship among obesity, intestinal microbiota and CRC in clinical and preclinical models were selected. Data extraction was carried out by two reviewers independently, and 101 studies were finally considered. Findings indicate the existence of a risk association between obesity and CRC derived from metabolic, immune, and microbial disorders.
Summary Microbiome modulation is one of the novel strategies in medicine with the greatest future to improve the health of individuals and reduce the risk of different conditions, including metabolic, immune, inflammatory, and degenerative diseases, as well as cancer. Regarding the latter, many studies have reported the role of the gut microbiome in carcinogenesis, formation and progression of colorectal cancer (CRC), as well as its response to different systemic therapies. Likewise, obesity, one of the most important risk factors for CRC, is also well known for its association with gut dysbiosis. Moreover, obesity and CRC display, apart from microbial dysbiosis, chronic inflammation, which participates in their pathogenesis. Although human and murine studies demonstrate the significant impact of the microbiome in regulating energy metabolism and CRC development, little is understood about the contribution of the microbiome to the development of obesity‐associated CRC. Therefore, this systematic review explores the evidence for microbiome changes associated with these conditions and hypothesizes that this may contribute to the pathogenesis of obesity‐related CRC. Two databases were searched, and different studies on the relationship among obesity, intestinal microbiota and CRC in clinical and preclinical models were selected. Data extraction was carried out by two reviewers independently, and 101 studies were finally considered. Findings indicate the existence of a risk association between obesity and CRC derived from metabolic, immune, and microbial disorders.
Microbiome modulation is one of the novel strategies in medicine with the greatest future to improve the health of individuals and reduce the risk of different conditions, including metabolic, immune, inflammatory, and degenerative diseases, as well as cancer. Regarding the latter, many studies have reported the role of the gut microbiome in carcinogenesis, formation and progression of colorectal cancer (CRC), as well as its response to different systemic therapies. Likewise, obesity, one of the most important risk factors for CRC, is also well known for its association with gut dysbiosis. Moreover, obesity and CRC display, apart from microbial dysbiosis, chronic inflammation, which participates in their pathogenesis. Although human and murine studies demonstrate the significant impact of the microbiome in regulating energy metabolism and CRC development, little is understood about the contribution of the microbiome to the development of obesity-associated CRC. Therefore, this systematic review explores the evidence for microbiome changes associated with these conditions and hypothesizes that this may contribute to the pathogenesis of obesity-related CRC. Two databases were searched, and different studies on the relationship among obesity, intestinal microbiota and CRC in clinical and preclinical models were selected. Data extraction was carried out by two reviewers independently, and 101 studies were finally considered. Findings indicate the existence of a risk association between obesity and CRC derived from metabolic, immune, and microbial disorders.Microbiome modulation is one of the novel strategies in medicine with the greatest future to improve the health of individuals and reduce the risk of different conditions, including metabolic, immune, inflammatory, and degenerative diseases, as well as cancer. Regarding the latter, many studies have reported the role of the gut microbiome in carcinogenesis, formation and progression of colorectal cancer (CRC), as well as its response to different systemic therapies. Likewise, obesity, one of the most important risk factors for CRC, is also well known for its association with gut dysbiosis. Moreover, obesity and CRC display, apart from microbial dysbiosis, chronic inflammation, which participates in their pathogenesis. Although human and murine studies demonstrate the significant impact of the microbiome in regulating energy metabolism and CRC development, little is understood about the contribution of the microbiome to the development of obesity-associated CRC. Therefore, this systematic review explores the evidence for microbiome changes associated with these conditions and hypothesizes that this may contribute to the pathogenesis of obesity-related CRC. Two databases were searched, and different studies on the relationship among obesity, intestinal microbiota and CRC in clinical and preclinical models were selected. Data extraction was carried out by two reviewers independently, and 101 studies were finally considered. Findings indicate the existence of a risk association between obesity and CRC derived from metabolic, immune, and microbial disorders.
Author Rodríguez‐Nogales, Alba
Rodríguez‐Sojo, María Jesús
Redondo, Eduardo
Rodríguez‐Cabezas, María Elena
Ruiz‐Malagón, Antonio Jesús
Gálvez, Julio
AuthorAffiliation 1 Department of Pharmacology, Center for Biomedical Research (CIBM) University of Granada Granada Spain
2 Instituto de Investigación Biosanitaria de Granada (ibs. GRANADA) Granada Spain
3 Instituto de Investigación Biomédica de Málaga (IBIMA) Malga Spain
4 Servicio de Digestivo Hospital Universitario Virgen de las Nieves Granada Spain
AuthorAffiliation_xml – name: 3 Instituto de Investigación Biomédica de Málaga (IBIMA) Malga Spain
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  givenname: Eduardo
  surname: Redondo
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  organization: Hospital Universitario Virgen de las Nieves
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  orcidid: 0000-0001-9085-8147
  surname: Rodríguez‐Cabezas
  fullname: Rodríguez‐Cabezas, María Elena
  email: merodri@ugr.es
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  surname: Rodríguez‐Nogales
  fullname: Rodríguez‐Nogales, Alba
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Cites_doi 10.1080/2162402X.2017.1328338
10.1016/j.cgh.2019.10.009
10.1158/1940‐6207.CAPR‐21‐0572
10.1371/journal.pone.0039743
10.1186/1476‐4598‐9‐249
10.1001/jamaoncol.2016.6374
10.32471/exp‐oncology.2312‐8852.vol‐43‐no‐3.16571
10.1016/j.yclnex.2018.03.001
10.1007/s10753‐020‐01309‐7
10.1371/journal.pone.0051848
10.3390/cancers11111629
10.1038/s41467‐018‐03773‐0
10.1016/j.cmet.2013.01.003
10.1021/acs.jafc.9b00249
10.3746/pnf.2020.25.2.113
10.1152/ajpgi.00324.2015
10.1016/j.bcp.2018.02.001
10.1016/j.jcmgh.2021.12.015
10.1159/000335672
10.1158/1055‐9965.EPI‐18‐0121
10.3390/molecules23092298
10.1038/s41467‐023‐36089‐9
10.3390/ijms23094905
10.1016/j.canlet.2021.09.024
10.1038/ncomms7528
10.1038/s41467‐021‐25333‐9
10.1002/mnfr.201901014
10.1038/nrc.2017.13
10.1158/1940‐6207.CAPR‐21‐0531
10.3389/fonc.2022.837781
10.3390/foods9121792
10.1016/j.fct.2013.10.028
10.1186/s12885‐016‐2938‐1
10.1186/s12935‐022‐02605‐y
10.1017/S000711451800212X
10.1007/s11033‐022‐07157‐y
10.1038/s41598‐023‐36111‐6
10.1111/cas.15208
10.3390/microorganisms8030431
10.18632/oncotarget.10064
10.3389/fonc.2021.685059
10.1002/jcp.22546
10.3390/cells10082060
10.1038/s41591‐019‐0458‐7
10.1158/2159‐8290.CD‐15‐0447
10.1126/science.aal5240
10.1002/jcp.28456
10.3389/fcimb.2020.00376
10.1101/gr.126516.111
10.1016/j.celrep.2017.12.071
10.1158/1940‐6207.CAPR‐12‐0140
10.3390/cancers12061406
10.1073/pnas.2302809120
10.7150/jca.15792
10.1093/ajcn/86.3.556
10.3390/ijms221910747
10.1002/mnfr.201801097
10.1371/journal.pone.0020447
10.1186/1471‐2407‐13‐91
10.1371/journal.pone.0135758
10.3389/fphar.2021.732541
10.1016/j.canlet.2019.11.019
10.1016/j.cell.2019.01.036
10.1038/nm.4358
10.3389/fphys.2019.01601
10.3945/ajcn.2010.29877
10.7150/ijbs.39098
10.1016/j.chom.2020.01.021
10.7150/ijbs.10684
10.1007/s10495‐011‐0633‐x
10.1038/s41366‐018‐0109‐y
10.3389/fmicb.2015.00020
10.1038/nrmicro2819
10.1002/mc.20856
10.1016/j.cmet.2015.10.015
10.1210/me.2009‐0498
10.2147/JIR.S335882
10.3390/ijms24021118
10.3389/fonc.2023.1087644
10.1002/mnfr.202100410
10.5009/gnl20266
10.1136/gutjnl‐2015‐309595
10.1038/ncomms9727
10.1038/s41598‐023‐29958‐2
10.1002/path.5134
10.1016/j.foodres.2021.110708
10.18632/oncotarget.12449
10.1186/s12866‐023‐02771‐7
10.1007/s12038‐011‐9172‐4
10.3390/ijms21186782
10.1152/physiolgenomics.00034.2016
10.1677/ERC‐10‐0083
10.1053/j.gastro.2021.08.041
10.1677/ERC‐09‐0252
10.1093/nutrit/nux001
10.1158/1055‐9965.EPI‐14‐0026
10.1002/oby.23659
10.1016/j.chom.2013.07.007
10.1016/j.molmet.2022.101498
10.1038/s42003‐022‐03486‐7
10.1016/j.ebiom.2023.104670
10.1038/s41419‐019‐1911‐8
10.3389/fendo.2022.983160
10.1080/19336918.2015.1134404
10.3390/cancers14112573
10.1016/j.jnutbio.2017.11.001
10.1038/nri2921
10.1159/000477890
10.1111/jcmm.14984
10.1158/0008‐5472.CAN‐10‐0178
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Copyright 2024 The Author(s). published by John Wiley & Sons Ltd on behalf of World Obesity Federation.
2024 The Author(s). Obesity Reviews published by John Wiley & Sons Ltd on behalf of World Obesity Federation.
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Issue 4
Keywords microbiota
colitis
colorectal cancer
obesity
Language English
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2024 The Author(s). Obesity Reviews published by John Wiley & Sons Ltd on behalf of World Obesity Federation.
This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
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Notes Antonio Jesús Ruiz‐Malagón and María Jesús Rodríguez‐Sojo contributed equally to this work.
Julio Gálvez and Alba Rodríguez‐Nogales contributed equally to the supervision of this work.
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– name: John Wiley and Sons Inc
References 2021; 65
2019; 11
2019; 10
2010; 17
2013; 62
2022; 23
2020; 16
2020; 12
2022; 22
2020; 10
2018; 42
2014; 23
2012; 10
2020; 18
2017; 75
2018; 9
2022; 162
2010; 24
2019; 25
2016; 310
2012; 22
2016; 48
2010; 9
2021; 43
2010; 36
2021; 44
2017; 66
2012; 37
2018; 23
2018; 22
2011; 6
2016; 16
2018; 20
2018; 27
2022; 113
2016; 7
2022; 5
2022; 12
2022; 13
2020; 27
2022; 14
2020; 25
2022; 15
2020; 24
2020; 21
2007; 86
2022; 16
2016; 23
2019; 176
2023; 31
2017; 6
2017; 42
2017; 3
2021; 22
2020; 64
2021; 522
2018; 246
2011; 11
2012; 58
2011; 16
2019; 122
2017; 358
2012; 51
2020; 8
2023; 24
2013; 14
2013; 17
2023; 23
2019; 63
2013; 13
2019; 67
2020; 9
2019; 234
2010; 70
2023; 13
2015; 6
2015; 5
2023; 14
2022; 152
2023; 120
2015; 11
2017; 23
2015; 10
2020; 469
2022; 49
2018; 153
2011; 226
2021; 14
2021; 10
2021; 12
2021; 11
2023
2017; 17
2022; 61
2017; 11
2010; 92
2012; 7
2018; 54
2012; 5
2023; 93
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e_1_2_9_79_1
e_1_2_9_94_1
Lee HY (e_1_2_9_103_1) 2010; 36
e_1_2_9_10_1
e_1_2_9_56_1
e_1_2_9_33_1
e_1_2_9_90_1
e_1_2_9_71_1
e_1_2_9_107_1
e_1_2_9_14_1
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e_1_2_9_2_1
e_1_2_9_111_1
e_1_2_9_26_1
e_1_2_9_49_1
e_1_2_9_30_1
e_1_2_9_53_1
e_1_2_9_99_1
e_1_2_9_72_1
e_1_2_9_11_1
e_1_2_9_34_1
e_1_2_9_57_1
e_1_2_9_76_1
e_1_2_9_91_1
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e_1_2_9_106_1
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e_1_2_9_80_1
e_1_2_9_5_1
Rodriguez‐Sojo MJ (e_1_2_9_95_1) 2023
e_1_2_9_9_1
e_1_2_9_27_1
e_1_2_9_69_1
e_1_2_9_110_1
e_1_2_9_31_1
e_1_2_9_50_1
e_1_2_9_73_1
e_1_2_9_35_1
e_1_2_9_77_1
e_1_2_9_96_1
e_1_2_9_12_1
e_1_2_9_54_1
e_1_2_9_92_1
e_1_2_9_109_1
e_1_2_9_101_1
e_1_2_9_105_1
e_1_2_9_39_1
e_1_2_9_16_1
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e_1_2_9_112_1
e_1_2_9_25_1
e_1_2_9_48_1
e_1_2_9_29_1
References_xml – volume: 25
  start-page: 113
  issue: 2
  year: 2020
  end-page: 123
  article-title: The influence of the gut microbiome on obesity in adults and the role of probiotics, prebiotics, and synbiotics for weight loss
  publication-title: Prev Nutr Food Sci
– volume: 16
  start-page: 882
  issue: 1
  year: 2016
  article-title: Leptin and insulin up‐regulate miR‐4443 to suppress NCOA1 and TRAF4, and decrease the invasiveness of human colon cancer cells
  publication-title: BMC Cancer
– volume: 5
  start-page: 1260
  issue: 11
  year: 2012
  end-page: 1272
  article-title: Obesity, energy balance, and cancer: new opportunities for prevention
  publication-title: Cancer Prev Res (Phila)
– volume: 86
  start-page: 556
  issue: 3
  year: 2007
  end-page: 565
  article-title: Obesity and colon and rectal cancer risk: a meta‐analysis of prospective studies
  publication-title: Am J Clin Nutr
– volume: 6
  start-page: 8727
  issue: 1
  year: 2015
  article-title: Gut mucosal microbiome across stages of colorectal carcinogenesis
  publication-title: Nat Commun
– volume: 15
  start-page: 481
  issue: 8
  year: 2022
  end-page: 495
  article-title: Weight loss and/or sulindac mitigate obesity‐associated transcriptome, microbiome, and protumor effects in a murine model of colon cancer
  publication-title: Cancer Prev Res (Phila)
– volume: 18
  start-page: 2752
  year: 2020
  end-page: 2759.e2
  article-title: Risk factors associated with early‐onset colorectal cancer
  publication-title: Clin Gastroenterol Hepatol
– start-page: 12
  year: 2023
  article-title: The prebiotic effects of an extract with antioxidant properties from L. contribute to ameliorate high‐fat diet‐induced obesity in mice
  publication-title: Antioxidants (Basel)
– volume: 42
  start-page: 1797
  issue: 10
  year: 2018
  end-page: 1803
  article-title: Change in weight status from childhood to early adulthood and late adulthood risk of colon cancer in men: a population‐based cohort study
  publication-title: Int J Obes (Lond)
– volume: 10
  start-page: 1601
  year: 2019
  article-title: Xylooligosaccharide modulates gut microbiota and alleviates colonic inflammation caused by high fat diet induced obesity
  publication-title: Front Physiol
– volume: 64
  issue: 8
  year: 2020
  article-title: Butyrate inhibits deoxycholic‐acid‐resistant colonic cell proliferation via cell cycle arrest and apoptosis: a potential pathway linking dietary fiber to cancer prevention
  publication-title: Mol Nutr Food Res
– volume: 13
  start-page: 8928
  issue: 1
  year: 2023
  article-title: The risk of colorectal cancer according to obesity status at four‐year intervals: a nationwide population‐based cohort study
  publication-title: Sci Rep
– volume: 17
  start-page: 823
  issue: 3
  year: 2010
  end-page: 833
  article-title: Obesity hormone leptin induces growth and interferes with the cytotoxic effects of 5‐fluorouracil in colorectal tumor stem cells
  publication-title: Endocr Relat Cancer
– volume: 9
  start-page: 249
  issue: 1
  year: 2010
  article-title: Molecular detection, quantification, and isolation of Streptococcus gallolyticus bacteria colonizing colorectal tumors: inflammation‐driven potential of carcinogenesis via IL‐1, COX‐2, and IL‐8
  publication-title: Mol Cancer
– volume: 54
  start-page: 18
  year: 2018
  end-page: 27
  article-title: Colonic aberrant crypt formation accompanies an increase of opportunistic pathogenic bacteria in C57BL/6 mice fed a high‐fat diet
  publication-title: J Nutr Biochem
– volume: 22
  issue: 19
  year: 2021
  article-title: 16S rRNA of mucosal colon microbiome and CCL2 circulating levels are potential biomarkers in colorectal cancer
  publication-title: Int J Mol Sci
– volume: 24
  start-page: 1441
  issue: 7
  year: 2010
  end-page: 1452
  article-title: Adiponectin represses colon cancer cell proliferation via AdipoR1‐ and ‐R2‐mediated AMPK activation
  publication-title: Mol Endocrinol
– volume: 22
  start-page: 299
  issue: 2
  year: 2012
  end-page: 306
  article-title: Fusobacterium nucleatum infection is prevalent in human colorectal carcinoma
  publication-title: Genome Res
– volume: 27
  start-page: 659
  year: 2020
  end-page: 670.e5
  article-title: Dysbiosis‐induced secondary bile acid deficiency promotes intestinal inflammation
  publication-title: Cell Host Microbe
– volume: 5
  start-page: 1098
  issue: 10
  year: 2015
  end-page: 1109
  article-title: Regulatory T‐cell response to enterotoxigenic Bacteroides fragilis colonization triggers IL17‐dependent colon carcinogenesis
  publication-title: Cancer Discov
– volume: 15
  start-page: 285
  issue: 5
  year: 2022
  end-page: 296
  article-title: The COX‐2‐PGE2 pathway promotes tumor evasion in colorectal adenomas
  publication-title: Cancer Prev Res (Phila)
– volume: 7
  start-page: 1780
  issue: 13
  year: 2016
  end-page: 1790
  article-title: Diet‐ and genetically‐induced obesity produces alterations in the microbiome, inflammation and Wnt pathway in the intestine of Apc(+/1638N) mice: comparisons and contrasts
  publication-title: J Cancer
– volume: 25
  start-page: 968
  issue: 6
  year: 2019
  end-page: 976
  article-title: Metagenomic and metabolomic analyses reveal distinct stage‐specific phenotypes of the gut microbiota in colorectal cancer
  publication-title: Nat Med
– volume: 10
  start-page: 376
  year: 2020
  article-title: High‐fat diet induced alteration of mice microbiota and the functional ability to utilize fructooligosaccharide for ethanol production
  publication-title: Front Cell Infect Microbiol
– volume: 5
  start-page: 553
  issue: 1
  year: 2022
  article-title: Platelets from patients with visceral obesity promote colon cancer growth
  publication-title: Commun Biol
– volume: 13
  year: 2023
  article-title: Targeting fat mass and obesity‐associated protein mitigates human colorectal cancer growth in vitro and in a murine model
  publication-title: Front Oncol
– volume: 469
  start-page: 456
  year: 2020
  end-page: 467
  article-title: Clostridium butyricum, a butyrate‐producing probiotic, inhibits intestinal tumor development through modulating Wnt signaling and gut microbiota
  publication-title: Cancer Lett
– volume: 43
  start-page: 261
  issue: 3
  year: 2021
  end-page: 265
  article-title: Redox dependent features of tumors, adipose tissue, neutrophiles and platelets in patients with metastatic colorectal cancer
  publication-title: Exp Oncol
– volume: 92
  start-page: 1023
  issue: 5
  year: 2010
  end-page: 1030
  article-title: Effect of mother's weight on infant's microbiota acquisition, composition, and activity during early infancy: a prospective follow‐up study initiated in early pregnancy
  publication-title: Am J Clin Nutr
– volume: 9
  start-page: 1646
  issue: 1
  year: 2018
  article-title: Obesity exacerbates colitis‐associated cancer via IL‐6‐regulated macrophage polarisation and CCL‐20/CCR‐6‐mediated lymphocyte recruitment
  publication-title: Nat Commun
– volume: 6
  issue: 5
  year: 2011
  article-title: Towards the human colorectal cancer microbiome
  publication-title: PLoS ONE
– volume: 51
  start-page: 869
  issue: 11
  year: 2012
  end-page: 880
  article-title: A high‐fat diet increases angiogenesis, solid tumor growth, and lung metastasis of CT26 colon cancer cells in obesity‐resistant BALB/c mice
  publication-title: Mol Carcinog
– volume: 9
  start-page: 9
  issue: 12
  year: 2020
  article-title: Highly branched Neo‐Fructans (Agavins) attenuate metabolic endotoxemia and low‐grade inflammation in association with gut microbiota modulation on high‐fat diet‐fed mice
  publication-title: Foods
– volume: 10
  issue: 8
  year: 2015
  article-title: Diet‐ and genetically‐induced obesity differentially affect the fecal microbiome and metabolome in Apc1638N mice
  publication-title: PLoS ONE
– volume: 20
  start-page: 60
  year: 2018
  end-page: 64
  article-title: Gut microbiota and obesity
  publication-title: Clinical Nutrition Experimental
– volume: 23
  start-page: 33
  issue: 1
  year: 2023
  article-title: Dysbiotic microbiome variation in colorectal cancer patients is linked to lifestyles and metabolic diseases
  publication-title: BMC Microbiol
– volume: 22
  start-page: 624
  issue: 3
  year: 2018
  end-page: 637
  article-title: Transcriptome and DNA methylome analysis in a mouse model of diet‐induced obesity predicts increased risk of colorectal cancer
  publication-title: Cell Rep
– volume: 13
  start-page: 1141
  issue: 4
  year: 2022
  end-page: 1159
  article-title: A high‐fat diet activates the BAs‐FXR axis and triggers cancer‐associated fibroblast properties in the colon
  publication-title: Cell Mol Gastroenterol Hepatol
– volume: 10
  start-page: 655
  issue: 9
  year: 2019
  article-title: Metallopanstimulin‐1 (MPS‐1) mediates the promotion effect of leptin on colorectal cancer through activation of JNK/c‐Jun signaling pathway
  publication-title: Cell Death Dis
– volume: 21
  issue: 18
  year: 2020
  article-title: Gut microbiota‐mediated inflammation and gut permeability in patients with obesity and colorectal cancer
  publication-title: Int J Mol Sci
– volume: 11
  start-page: 274
  issue: 3
  year: 2015
  end-page: 283
  article-title: Protracted upregulation of leptin and IGF1 is associated with activation of PI3K/Akt and JAK2 pathway in mouse intestine after ionizing radiation exposure
  publication-title: Int J Biol Sci
– volume: 66
  start-page: 633
  issue: 4
  year: 2017
  end-page: 643
  article-title: Tumour‐associated and non‐tumour‐associated microbiota in colorectal cancer
  publication-title: Gut
– volume: 12
  start-page: 12
  issue: 6
  year: 2020
  article-title: The role of the gut microbiome in colorectal cancer development and therapy response
  publication-title: Cancers (Basel)
– volume: 120
  issue: 31
  year: 2023
  article-title: Prostaglandin E(2) activates melanin‐concentrating hormone neurons to drive diet‐induced obesity
  publication-title: Proc Natl Acad Sci U S A
– volume: 23
  start-page: 859
  issue: 7
  year: 2017
  end-page: 868
  article-title: Gut microbiome and serum metabolome alterations in obesity and after weight‐loss intervention
  publication-title: Nat Med
– volume: 14
  start-page: 6431
  year: 2021
  end-page: 6446
  article-title: The differential expression of the Inflammasomes in adipose tissue and colon influences the development of colon cancer in a context of obesity by regulating intestinal inflammation
  publication-title: J Inflamm Res
– volume: 65
  issue: 17
  year: 2021
  article-title: Inhibitory effect of garcinol on obesity‐exacerbated, colitis‐mediated colon carcinogenesis
  publication-title: Mol Nutr Food Res
– volume: 152
  year: 2022
  article-title: Kefir modulates gut microbiota and reduces DMH‐associated colorectal cancer via regulation of intestinal inflammation in adulthood offsprings programmed by neonatal overfeeding
  publication-title: Food Res Int
– volume: 14
  start-page: 14
  issue: 11
  year: 2022
  article-title: High‐fat diet enhances the liver metastasis potential of colorectal cancer through microbiota Dysbiosis
  publication-title: Cancers (Basel).
– volume: 246
  start-page: 217
  issue: 2
  year: 2018
  end-page: 230
  article-title: Increased jejunal permeability in human obesity is revealed by a lipid challenge and is linked to inflammation and type 2 diabetes
  publication-title: J Pathol
– volume: 14
  start-page: 755
  issue: 1
  year: 2023
  article-title: Bile salt hydrolase in non‐enterotoxigenic Bacteroides potentiates colorectal cancer
  publication-title: Nat Commun
– volume: 8
  start-page: 8
  issue: 3
  year: 2020
  article-title: The obesity‐related gut bacterial and viral dysbiosis can impact the risk of colon cancer development
  publication-title: Microorganisms
– volume: 7
  start-page: 46158
  issue: 29
  year: 2016
  end-page: 46172
  article-title: Could gut microbiota serve as prognostic biomarker associated with colorectal cancer patients' survival? A pilot study on relevant mechanism
  publication-title: Oncotarget
– volume: 3
  start-page: 921
  issue: 7
  year: 2017
  end-page: 927
  article-title: Association of dietary patterns with risk of colorectal cancer subtypes classified by Fusobacterium nucleatum in tumor tissue
  publication-title: JAMA Oncol
– volume: 358
  start-page: 1443
  issue: 6369
  year: 2017
  end-page: 1448
  article-title: Analysis of Fusobacterium persistence and antibiotic response in colorectal cancer
  publication-title: Science
– volume: 36
  start-page: 941
  issue: 4
  year: 2010
  end-page: 953
  article-title: Bile acid regulates MUC2 transcription in colon cancer cells via positive EGFR/PKC/Ras/ERK/CREB, PI3K/Akt/IkappaB/NF‐kappaB and p38/MSK1/CREB pathways and negative JNK/c‐Jun/AP‐1 pathway
  publication-title: Int J Oncol
– volume: 27
  start-page: 1416
  issue: 12
  year: 2018
  end-page: 1423
  article-title: Incremental elevations in TNFalpha and IL6 in the human colon and procancerous changes in the mucosal transcriptome accompany adiposity
  publication-title: Cancer Epidemiol Biomarkers Prev
– volume: 13
  start-page: 2858
  issue: 1
  year: 2023
  article-title: Modulation of AMPK/TET2/5‐hmC axis in response to metabolic alterations as a novel pathway for obesity‐related colorectal cancer development
  publication-title: Sci Rep
– volume: 63
  issue: 8
  year: 2019
  article-title: The combination of curcumin and salsalate is superior to either agent alone in suppressing pro‐cancerous molecular pathways and colorectal tumorigenesis in obese mice
  publication-title: Mol Nutr Food Res
– volume: 12
  year: 2022
  article-title: Mesenchymal stem cells derived from adipose tissue accelerate the progression of colon cancer by inducing a MTCAF phenotype via ICAM1/STAT3/AKT axis
  publication-title: Front Oncol
– volume: 153
  start-page: 282
  year: 2018
  end-page: 291
  article-title: Leptin induces SIRT1 expression through activation of NF‐E2‐related factor 2: implications for obesity‐associated colon carcinogenesis
  publication-title: Biochem Pharmacol
– volume: 48
  start-page: 545
  issue: 8
  year: 2016
  end-page: 553
  article-title: Interactions between the colonic transcriptome, metabolome, and microbiome in mouse models of obesity‐induced intestinal cancer
  publication-title: Physiol Genomics
– volume: 24
  issue: 2
  year: 2023
  article-title: Neutrophil extracellular traps promote metastases of colorectal cancers through activation of ERK signaling by releasing neutrophil elastase
  publication-title: Int J Mol Sci
– volume: 13
  year: 2022
  article-title: Insulin resistance and inflammation mediate the association of abdominal obesity with colorectal cancer risk
  publication-title: Front Endocrinol (Lausanne)
– volume: 12
  start-page: 5006
  issue: 1
  year: 2021
  article-title: Adipose stem cell niche reprograms the colorectal cancer stem cell metastatic machinery
  publication-title: Nat Commun
– volume: 226
  start-page: 2123
  issue: 8
  year: 2011
  end-page: 2130
  article-title: Leptin up‐regulates pro‐inflammatory cytokines in discrete cells within mouse colon
  publication-title: J Cell Physiol
– volume: 14
  start-page: 207
  issue: 2
  year: 2013
  end-page: 215
  article-title: Fusobacterium nucleatum potentiates intestinal tumorigenesis and modulates the tumor‐immune microenvironment
  publication-title: Cell Host Microbe
– volume: 17
  start-page: 351
  issue: 2
  year: 2010
  end-page: 360
  article-title: Metformin blocks the stimulative effect of a high‐energy diet on colon carcinoma growth in vivo and is associated with reduced expression of fatty acid synthase
  publication-title: Endocr Relat Cancer
– volume: 310
  start-page: G367
  issue: 6
  year: 2016
  end-page: G375
  article-title: Protective effect of Agaro‐oligosaccharides on gut dysbiosis and colon tumorigenesis in high‐fat diet‐fed mice
  publication-title: Am J Physiol Gastrointest Liver Physiol
– volume: 11
  start-page: 85
  issue: 2
  year: 2011
  end-page: 97
  article-title: Adipokines in inflammation and metabolic disease
  publication-title: Nat Rev Immunol
– volume: 23
  start-page: 77
  issue: 1
  year: 2016
  end-page: 93
  article-title: Leptin, BMI, and a metabolic gene expression signature associated with clinical outcome to VEGF inhibition in colorectal cancer
  publication-title: Cell Metab
– volume: 67
  start-page: 3624
  issue: 13
  year: 2019
  end-page: 3632
  article-title: Alterations of bile acids and gut microbiota in obesity induced by high fat diet in rat model
  publication-title: J Agric Food Chem
– volume: 10
  start-page: 10
  issue: 8
  year: 2021
  article-title: Anti‐obesity drug orlistat alleviates Western‐diet‐driven colitis‐associated colon cancer via inhibition of STAT3 and NF‐kappaB‐mediated signaling
  publication-title: Cells
– volume: 11
  start-page: 11
  issue: 11
  year: 2019
  article-title: The expression/methylation profile of adipogenic and inflammatory transcription factors in adipose tissue are linked to obesity‐related colorectal cancer
  publication-title: Cancers (Basel).
– volume: 23
  issue: 9
  year: 2018
  article-title: The effects of berberine on the gut microbiota in Apc ( ) mice fed with a high fat diet
  publication-title: Molecules
– volume: 12
  year: 2021
  article-title: Distinctive gut microbiota in patients with overweight and obesity with dyslipidemia and its responses to long‐term orlistat and ezetimibe intervention: a randomized controlled open‐label trial
  publication-title: Front Pharmacol
– volume: 10
  start-page: 575
  issue: 8
  year: 2012
  end-page: 582
  article-title: A bacterial driver‐passenger model for colorectal cancer: beyond the usual suspects
  publication-title: Nat Rev Microbiol
– volume: 62
  start-page: 892
  year: 2013
  end-page: 900
  article-title: Butyrate suppresses proliferation and migration of RKO colon cancer cells though regulating endocan expression by MAPK signaling pathway
  publication-title: Food Chem Toxicol
– volume: 37
  start-page: 91
  issue: 1
  year: 2012
  end-page: 101
  article-title: Leptin regulates proliferation and apoptosis of colorectal carcinoma through PI3K/Akt/mTOR signalling pathway
  publication-title: J Biosci
– volume: 6
  start-page: 20
  year: 2015
  article-title: Microbiota disbiosis is associated with colorectal cancer
  publication-title: Front Microbiol
– volume: 16
  start-page: 1054
  issue: 10
  year: 2011
  end-page: 1067
  article-title: Deoxycholic and chenodeoxycholic bile acids induce apoptosis via oxidative stress in human colon adenocarcinoma cells
  publication-title: Apoptosis
– volume: 23
  issue: 9
  year: 2022
  article-title: Modulation of mismatch repair and the SOCS1/p53 axis by microRNA‐155 in the colon of patients with primary sclerosing cholangitis
  publication-title: Int J Mol Sci
– volume: 17
  start-page: 225
  issue: 2
  year: 2013
  end-page: 235
  article-title: Gut microbiota regulates bile acid metabolism by reducing the levels of tauro‐beta‐muricholic acid, a naturally occurring FXR antagonist
  publication-title: Cell Metab
– volume: 6
  start-page: 6528
  issue: 1
  year: 2015
  article-title: Gut microbiome development along the colorectal adenoma‐carcinoma sequence
  publication-title: Nat Commun
– volume: 234
  start-page: 18249
  issue: 10
  year: 2019
  end-page: 18261
  article-title: Conditioned media from adipocytes promote proliferation, migration, and invasion in melanoma and colorectal cancer cells
  publication-title: J Cell Physiol
– volume: 11
  year: 2021
  article-title: Oleic acid and insulin as key characteristics of T2D promote colorectal cancer deterioration in xenograft mice revealed by functional metabolomics
  publication-title: Front Oncol
– volume: 7
  issue: 12
  year: 2012
  article-title: Crucial involvement of tumor‐associated neutrophils in the regulation of chronic colitis‐associated carcinogenesis in mice
  publication-title: PLoS ONE
– volume: 122
  start-page: 499
  issue: 5
  year: 2019
  end-page: 508
  article-title: Hypomethylation of NANOG promoter in colonic mucosal cells of obese patients: a possible role of NF‐kappaB
  publication-title: Br J Nutr
– volume: 16
  start-page: 53
  issue: 1
  year: 2022
  end-page: 61
  article-title: Impact of visceral fat on survival and metastasis of stage III colorectal cancer
  publication-title: Gut Liver
– volume: 75
  start-page: 374
  issue: 5
  year: 2017
  end-page: 389
  article-title: Dietary metabolites derived from gut microbiota: critical modulators of epigenetic changes in mammals
  publication-title: Nutr Rev
– volume: 176
  start-page: 1098
  year: 2019
  end-page: 1112.e18
  article-title: FXR regulates intestinal cancer stem cell proliferation
  publication-title: Cell
– volume: 61
  year: 2022
  article-title: Metformin‐induced reductions in tumor growth involves modulation of the gut microbiome
  publication-title: Mol Metab
– volume: 70
  start-page: 5430
  issue: 13
  year: 2010
  end-page: 5437
  article-title: Interaction between adiponectin and leptin influences the risk of colorectal adenoma
  publication-title: Cancer Res
– volume: 31
  start-page: 412
  issue: 2
  year: 2023
  end-page: 422
  article-title: Metagenomic characterization of the maternal prenatal gastrointestinal microbiome by pregravid BMI
  publication-title: Obesity (Silver Spring)
– volume: 93
  year: 2023
  article-title: Altered gut microbiota of obesity subjects promotes colorectal carcinogenesis in mice
  publication-title: EBioMedicine
– volume: 13
  start-page: 91
  issue: 1
  year: 2013
  article-title: Association of plasma endotoxin, inflammatory cytokines and risk of colorectal adenomas
  publication-title: BMC Cancer
– volume: 7
  start-page: 73711
  issue: 45
  year: 2016
  end-page: 73724
  article-title: Lipopolysaccharide increases the release of VEGF‐C that enhances cell motility and promotes lymphangiogenesis and lymphatic metastasis through the TLR4‐ NF‐kappaB/JNK pathways in colorectal cancer
  publication-title: Oncotarget
– volume: 7
  issue: 6
  year: 2012
  article-title: Human intestinal lumen and mucosa‐associated microbiota in patients with colorectal cancer
  publication-title: PLoS ONE
– volume: 24
  start-page: 2648
  issue: 4
  year: 2020
  end-page: 2662
  article-title: High‐fat diet‐induced dysbiosis mediates MCP‐1/CCR2 axis‐dependent M2 macrophage polarization and promotes intestinal adenoma‐adenocarcinoma sequence
  publication-title: J Cell Mol Med
– volume: 6
  year: 2017
  article-title: IL‐32alpha‐induced inflammation constitutes a link between obesity and colon cancer
  publication-title: Onco Targets Ther
– volume: 113
  start-page: 459
  issue: 2
  year: 2022
  end-page: 477
  article-title: Microbial metabolite deoxycholic acid promotes vasculogenic mimicry formation in intestinal carcinogenesis
  publication-title: Cancer Sci
– volume: 58
  start-page: 102
  issue: 2
  year: 2012
  end-page: 109
  article-title: Short‐chain fatty acids induce apoptosis in colon cancer cells associated with changes to intracellular redox state and glucose metabolism
  publication-title: Chemotherapy
– volume: 49
  start-page: 3225
  issue: 4
  year: 2022
  end-page: 3236
  article-title: Neutrophil extracellular traps (NETs) modulate inflammatory profile in obese humans and mice: adipose tissue role on NETs levels
  publication-title: Mol Biol Rep
– volume: 11
  start-page: 13
  issue: 1
  year: 2017
  end-page: 23
  article-title: LPS‐induced CXCR4‐dependent migratory properties and a mesenchymal‐like phenotype of colorectal cancer cells
  publication-title: Cell Adh Migr
– volume: 42
  start-page: 729
  issue: 2
  year: 2017
  end-page: 742
  article-title: Cholesterol enhances colorectal cancer progression via ROS elevation and MAPK signaling pathway activation
  publication-title: Cell Physiol Biochem
– volume: 16
  start-page: 1288
  issue: 8
  year: 2020
  end-page: 1302
  article-title: Selective targeting of the TLR4 co‐receptor, MD2, prevents colon cancer growth and lung metastasis
  publication-title: Int J Biol Sci
– volume: 522
  start-page: 93
  year: 2021
  end-page: 104
  article-title: Fas signaling in adipocytes promotes low‐grade inflammation and lung metastasis of colorectal cancer through interaction with Bmx
  publication-title: Cancer Lett
– volume: 162
  start-page: 135
  year: 2022
  end-page: 149.e2
  article-title: High‐fat diet promotes colorectal tumorigenesis through modulating gut microbiota and metabolites
  publication-title: Gastroenterology
– volume: 22
  start-page: 196
  issue: 1
  year: 2022
  article-title: Recent advances in targeted drug delivery systems for resistant colorectal cancer
  publication-title: Cancer Cell Int
– volume: 17
  start-page: 271
  issue: 5
  year: 2017
  end-page: 285
  article-title: Microbiota: a key orchestrator of cancer therapy
  publication-title: Nat Rev Cancer
– volume: 23
  start-page: 2413
  issue: 11
  year: 2014
  end-page: 2421
  article-title: Colonic mucosal fatty acid synthase as an early biomarker for colorectal neoplasia: modulation by obesity and gender
  publication-title: Cancer Epidemiol Biomarkers Prev
– volume: 44
  start-page: 68
  issue: 1
  year: 2021
  end-page: 79
  article-title: The combinatorial effect of acetate and propionate on high‐fat diet induced diabetic inflammation or metaflammation and T cell polarization
  publication-title: Inflammation
– ident: e_1_2_9_35_1
  doi: 10.1080/2162402X.2017.1328338
– ident: e_1_2_9_36_1
  doi: 10.1016/j.cgh.2019.10.009
– ident: e_1_2_9_72_1
  doi: 10.1158/1940‐6207.CAPR‐21‐0572
– ident: e_1_2_9_58_1
  doi: 10.1371/journal.pone.0039743
– ident: e_1_2_9_64_1
  doi: 10.1186/1476‐4598‐9‐249
– ident: e_1_2_9_3_1
  doi: 10.1001/jamaoncol.2016.6374
– ident: e_1_2_9_45_1
  doi: 10.32471/exp‐oncology.2312‐8852.vol‐43‐no‐3.16571
– ident: e_1_2_9_9_1
  doi: 10.1016/j.yclnex.2018.03.001
– ident: e_1_2_9_112_1
  doi: 10.1007/s10753‐020‐01309‐7
– ident: e_1_2_9_48_1
  doi: 10.1371/journal.pone.0051848
– ident: e_1_2_9_37_1
  doi: 10.3390/cancers11111629
– ident: e_1_2_9_40_1
  doi: 10.1038/s41467‐018‐03773‐0
– ident: e_1_2_9_106_1
  doi: 10.1016/j.cmet.2013.01.003
– ident: e_1_2_9_99_1
  doi: 10.1021/acs.jafc.9b00249
– ident: e_1_2_9_10_1
  doi: 10.3746/pnf.2020.25.2.113
– ident: e_1_2_9_92_1
  doi: 10.1152/ajpgi.00324.2015
– ident: e_1_2_9_30_1
  doi: 10.1016/j.bcp.2018.02.001
– ident: e_1_2_9_102_1
  doi: 10.1016/j.jcmgh.2021.12.015
– ident: e_1_2_9_109_1
  doi: 10.1159/000335672
– ident: e_1_2_9_17_1
  doi: 10.1158/1055‐9965.EPI‐18‐0121
– ident: e_1_2_9_88_1
  doi: 10.3390/molecules23092298
– ident: e_1_2_9_78_1
  doi: 10.1038/s41467‐023‐36089‐9
– ident: e_1_2_9_105_1
  doi: 10.3390/ijms23094905
– ident: e_1_2_9_39_1
  doi: 10.1016/j.canlet.2021.09.024
– ident: e_1_2_9_56_1
  doi: 10.1038/ncomms7528
– ident: e_1_2_9_41_1
  doi: 10.1038/s41467‐021‐25333‐9
– ident: e_1_2_9_101_1
  doi: 10.1002/mnfr.201901014
– ident: e_1_2_9_12_1
  doi: 10.1038/nrc.2017.13
– ident: e_1_2_9_80_1
  doi: 10.1158/1940‐6207.CAPR‐21‐0531
– ident: e_1_2_9_42_1
  doi: 10.3389/fonc.2022.837781
– ident: e_1_2_9_53_1
  doi: 10.3390/foods9121792
– ident: e_1_2_9_108_1
  doi: 10.1016/j.fct.2013.10.028
– ident: e_1_2_9_74_1
  doi: 10.1186/s12885‐016‐2938‐1
– ident: e_1_2_9_2_1
  doi: 10.1186/s12935‐022‐02605‐y
– ident: e_1_2_9_38_1
  doi: 10.1017/S000711451800212X
– ident: e_1_2_9_44_1
  doi: 10.1007/s11033‐022‐07157‐y
– ident: e_1_2_9_16_1
  doi: 10.1038/s41598‐023‐36111‐6
– ident: e_1_2_9_85_1
  doi: 10.1111/cas.15208
– ident: e_1_2_9_54_1
  doi: 10.3390/microorganisms8030431
– ident: e_1_2_9_69_1
  doi: 10.18632/oncotarget.10064
– ident: e_1_2_9_26_1
  doi: 10.3389/fonc.2021.685059
– ident: e_1_2_9_33_1
  doi: 10.1002/jcp.22546
– ident: e_1_2_9_43_1
  doi: 10.3390/cells10082060
– ident: e_1_2_9_61_1
  doi: 10.1038/s41591‐019‐0458‐7
– ident: e_1_2_9_70_1
  doi: 10.1158/2159‐8290.CD‐15‐0447
– ident: e_1_2_9_11_1
  doi: 10.1126/science.aal5240
– ident: e_1_2_9_20_1
  doi: 10.1002/jcp.28456
– ident: e_1_2_9_111_1
  doi: 10.3389/fcimb.2020.00376
– ident: e_1_2_9_59_1
  doi: 10.1101/gr.126516.111
– ident: e_1_2_9_110_1
  doi: 10.1016/j.celrep.2017.12.071
– ident: e_1_2_9_6_1
  doi: 10.1158/1940‐6207.CAPR‐12‐0140
– ident: e_1_2_9_8_1
  doi: 10.3390/cancers12061406
– ident: e_1_2_9_71_1
  doi: 10.1073/pnas.2302809120
– ident: e_1_2_9_91_1
  doi: 10.7150/jca.15792
– ident: e_1_2_9_4_1
  doi: 10.1093/ajcn/86.3.556
– ident: e_1_2_9_67_1
  doi: 10.3390/ijms221910747
– ident: e_1_2_9_28_1
  doi: 10.1002/mnfr.201801097
– ident: e_1_2_9_66_1
  doi: 10.1371/journal.pone.0020447
– ident: e_1_2_9_96_1
  doi: 10.1186/1471‐2407‐13‐91
– ident: e_1_2_9_93_1
  doi: 10.1371/journal.pone.0135758
– ident: e_1_2_9_51_1
  doi: 10.3389/fphar.2021.732541
– ident: e_1_2_9_60_1
  doi: 10.1016/j.canlet.2019.11.019
– ident: e_1_2_9_107_1
  doi: 10.1016/j.cell.2019.01.036
– ident: e_1_2_9_68_1
  doi: 10.1038/nm.4358
– ident: e_1_2_9_87_1
  doi: 10.3389/fphys.2019.01601
– ident: e_1_2_9_50_1
  doi: 10.3945/ajcn.2010.29877
– ident: e_1_2_9_97_1
  doi: 10.7150/ijbs.39098
– ident: e_1_2_9_100_1
  doi: 10.1016/j.chom.2020.01.021
– ident: e_1_2_9_31_1
  doi: 10.7150/ijbs.10684
– ident: e_1_2_9_104_1
  doi: 10.1007/s10495‐011‐0633‐x
– ident: e_1_2_9_13_1
  doi: 10.1038/s41366‐018‐0109‐y
– ident: e_1_2_9_57_1
  doi: 10.3389/fmicb.2015.00020
– ident: e_1_2_9_62_1
  doi: 10.1038/nrmicro2819
– ident: e_1_2_9_73_1
  doi: 10.1002/mc.20856
– ident: e_1_2_9_25_1
  doi: 10.1016/j.cmet.2015.10.015
– ident: e_1_2_9_21_1
  doi: 10.1210/me.2009‐0498
– ident: e_1_2_9_77_1
  doi: 10.2147/JIR.S335882
– ident: e_1_2_9_46_1
  doi: 10.3390/ijms24021118
– ident: e_1_2_9_27_1
  doi: 10.3389/fonc.2023.1087644
– ident: e_1_2_9_86_1
  doi: 10.1002/mnfr.202100410
– ident: e_1_2_9_14_1
  doi: 10.5009/gnl20266
– start-page: 12
  year: 2023
  ident: e_1_2_9_95_1
  article-title: The prebiotic effects of an extract with antioxidant properties from Morus alba L. contribute to ameliorate high‐fat diet‐induced obesity in mice
  publication-title: Antioxidants (Basel)
– ident: e_1_2_9_55_1
  doi: 10.1136/gutjnl‐2015‐309595
– ident: e_1_2_9_65_1
  doi: 10.1038/ncomms9727
– ident: e_1_2_9_22_1
  doi: 10.1038/s41598‐023‐29958‐2
– ident: e_1_2_9_52_1
  doi: 10.1002/path.5134
– ident: e_1_2_9_83_1
  doi: 10.1016/j.foodres.2021.110708
– ident: e_1_2_9_94_1
  doi: 10.18632/oncotarget.12449
– ident: e_1_2_9_76_1
  doi: 10.1186/s12866‐023‐02771‐7
– ident: e_1_2_9_29_1
  doi: 10.1007/s12038‐011‐9172‐4
– ident: e_1_2_9_75_1
  doi: 10.3390/ijms21186782
– ident: e_1_2_9_90_1
  doi: 10.1152/physiolgenomics.00034.2016
– ident: e_1_2_9_32_1
  doi: 10.1677/ERC‐10‐0083
– ident: e_1_2_9_84_1
  doi: 10.1053/j.gastro.2021.08.041
– ident: e_1_2_9_24_1
  doi: 10.1677/ERC‐09‐0252
– ident: e_1_2_9_7_1
  doi: 10.1093/nutrit/nux001
– ident: e_1_2_9_23_1
  doi: 10.1158/1055‐9965.EPI‐14‐0026
– ident: e_1_2_9_49_1
  doi: 10.1002/oby.23659
– ident: e_1_2_9_63_1
  doi: 10.1016/j.chom.2013.07.007
– ident: e_1_2_9_81_1
  doi: 10.1016/j.molmet.2022.101498
– ident: e_1_2_9_15_1
  doi: 10.1038/s42003‐022‐03486‐7
– volume: 36
  start-page: 941
  issue: 4
  year: 2010
  ident: e_1_2_9_103_1
  article-title: Bile acid regulates MUC2 transcription in colon cancer cells via positive EGFR/PKC/Ras/ERK/CREB, PI3K/Akt/IkappaB/NF‐kappaB and p38/MSK1/CREB pathways and negative JNK/c‐Jun/AP‐1 pathway
  publication-title: Int J Oncol
– ident: e_1_2_9_79_1
  doi: 10.1016/j.ebiom.2023.104670
– ident: e_1_2_9_18_1
  doi: 10.1038/s41419‐019‐1911‐8
– ident: e_1_2_9_34_1
  doi: 10.3389/fendo.2022.983160
– ident: e_1_2_9_98_1
  doi: 10.1080/19336918.2015.1134404
– ident: e_1_2_9_82_1
  doi: 10.3390/cancers14112573
– ident: e_1_2_9_89_1
  doi: 10.1016/j.jnutbio.2017.11.001
– ident: e_1_2_9_5_1
  doi: 10.1038/nri2921
– ident: e_1_2_9_47_1
  doi: 10.1159/000477890
– ident: e_1_2_9_113_1
  doi: 10.1111/jcmm.14984
– ident: e_1_2_9_19_1
  doi: 10.1158/0008‐5472.CAN‐10‐0178
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Snippet Summary Microbiome modulation is one of the novel strategies in medicine with the greatest future to improve the health of individuals and reduce the risk of...
Microbiome modulation is one of the novel strategies in medicine with the greatest future to improve the health of individuals and reduce the risk of different...
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StartPage e13872
SubjectTerms Animals
Cancer
Carcinogenesis
Carcinogens
colitis
Colorectal cancer
Colorectal carcinoma
colorectal neoplasms
Colorectal Neoplasms - etiology
Colorectal Neoplasms - microbiology
Digestive system
Dysbacteriosis
dysbiosis
Dysbiosis - complications
Energy metabolism
Gastrointestinal Microbiome - physiology
Gastrointestinal tract
Gut microbiota
Health risks
Humans
inflammation
Intestinal microflora
intestinal microorganisms
medicine
Metabolism
mice
microbiome
Microbiomes
Microbiota
Microorganisms
Obesity
Obesity - complications
Obesity - microbiology
Pathogenesis
Review
risk
Risk Factors
risk reduction
Systematic review
Title Systematic review: The gut microbiota as a link between colorectal cancer and obesity
URI https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fobr.13872
https://www.ncbi.nlm.nih.gov/pubmed/39614602
https://www.proquest.com/docview/3174524760
https://www.proquest.com/docview/3134333005
https://www.proquest.com/docview/3200301568
https://pubmed.ncbi.nlm.nih.gov/PMC11884970
Volume 26
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