Systematic review: The gut microbiota as a link between colorectal cancer and obesity

Summary Microbiome modulation is one of the novel strategies in medicine with the greatest future to improve the health of individuals and reduce the risk of different conditions, including metabolic, immune, inflammatory, and degenerative diseases, as well as cancer. Regarding the latter, many stud...

Full description

Saved in:
Bibliographic Details
Published in:Obesity reviews Vol. 26; no. 4; pp. e13872 - n/a
Main Authors: Ruiz‐Malagón, Antonio Jesús, Rodríguez‐Sojo, María Jesús, Redondo, Eduardo, Rodríguez‐Cabezas, María Elena, Gálvez, Julio, Rodríguez‐Nogales, Alba
Format: Journal Article
Language:English
Published: England Wiley Subscription Services, Inc 01.04.2025
John Wiley and Sons Inc
Subjects:
Animals
Cancer
Carcinogenesis
Carcinogens
colitis
Colorectal cancer
Colorectal carcinoma
colorectal neoplasms
Colorectal Neoplasms - etiology
Colorectal Neoplasms - microbiology
Digestive system
Dysbacteriosis
dysbiosis
Dysbiosis - complications
Energy metabolism
Gastrointestinal Microbiome - physiology
Gastrointestinal tract
Gut microbiota
Health risks
Humans
inflammation
Intestinal microflora
intestinal microorganisms
medicine
Metabolism
mice
microbiome
Microbiomes
Microbiota
Microorganisms
Obesity
Obesity - complications
Obesity - microbiology
Pathogenesis
Review
risk
Risk Factors
risk reduction
Systematic review
microbiota
colitis
colorectal cancer
obesity
ISSN:1467-7881, 1467-789X, 1467-789X
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Summary Microbiome modulation is one of the novel strategies in medicine with the greatest future to improve the health of individuals and reduce the risk of different conditions, including metabolic, immune, inflammatory, and degenerative diseases, as well as cancer. Regarding the latter, many studies have reported the role of the gut microbiome in carcinogenesis, formation and progression of colorectal cancer (CRC), as well as its response to different systemic therapies. Likewise, obesity, one of the most important risk factors for CRC, is also well known for its association with gut dysbiosis. Moreover, obesity and CRC display, apart from microbial dysbiosis, chronic inflammation, which participates in their pathogenesis. Although human and murine studies demonstrate the significant impact of the microbiome in regulating energy metabolism and CRC development, little is understood about the contribution of the microbiome to the development of obesity‐associated CRC. Therefore, this systematic review explores the evidence for microbiome changes associated with these conditions and hypothesizes that this may contribute to the pathogenesis of obesity‐related CRC. Two databases were searched, and different studies on the relationship among obesity, intestinal microbiota and CRC in clinical and preclinical models were selected. Data extraction was carried out by two reviewers independently, and 101 studies were finally considered. Findings indicate the existence of a risk association between obesity and CRC derived from metabolic, immune, and microbial disorders.
Bibliography:Antonio Jesús Ruiz‐Malagón and María Jesús Rodríguez‐Sojo contributed equally to this work.
Julio Gálvez and Alba Rodríguez‐Nogales contributed equally to the supervision of this work.
ObjectType-Article-2
SourceType-Scholarly Journals-1
content type line 14
ObjectType-Feature-3
ObjectType-Evidence Based Healthcare-1
ObjectType-Undefined-1
ObjectType-Review-4
content type line 23
ObjectType-Article-1
ObjectType-Feature-2
ISSN:1467-7881
1467-789X
1467-789X
DOI:10.1111/obr.13872