The association between urinary metabolites of polycyclic aromatic hydrocarbons and diabetes: A systematic review and meta-analysis study

To examine the association between urinary metabolites of polycyclic aromatic hydrocarbons (OH-PAHs) and diabetes, online databases, including PubMed, Scopus, and Web of Science, were searched on July 17, 2019. Of the 668 articles identified through searching, six cross-sectional studies involving 2...

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Bibliographic Details
Published in:Chemosphere (Oxford) Vol. 247; p. 125680
Main Authors: Khosravipour, Masoud, Khosravipour, Hadis
Format: Journal Article
Language:English
Published: England Elsevier Ltd 01.05.2020
Subjects:
confidence interval
cross-sectional studies
Diabetes
Diabetes Mellitus - urine
Female
fluorine
Fluorine - urine
Humans
Hydroxylation
Male
Meta-analysis
metabolites
Mono-hydroxylated polycyclic aromatic hydrocarbons
Monohydroxy polycyclic aromatic hydrocarbons
naphthalene
Naphthalenes - urine
Odds Ratio
OH-PAHs
phenanthrenes
Phenanthrenes - urine
Polycyclic aromatic hydrocarbons
Polycyclic Aromatic Hydrocarbons - metabolism
Polycyclic Aromatic Hydrocarbons - urine
systematic review
Mono-hydroxylated polycyclic aromatic hydrocarbons
OH-PAHs
Diabetes
Polycyclic aromatic hydrocarbons
Monohydroxy polycyclic aromatic hydrocarbons
Meta-analysis
ISSN:0045-6535, 1879-1298, 1879-1298
Online Access:Get full text
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Summary:To examine the association between urinary metabolites of polycyclic aromatic hydrocarbons (OH-PAHs) and diabetes, online databases, including PubMed, Scopus, and Web of Science, were searched on July 17, 2019. Of the 668 articles identified through searching, six cross-sectional studies involving 24,406 participants were included. The pooled odds ratio (OR) and 95% confidence interval (CI) were calculated using a random-effect model. Heterogeneity was measured by reporting the I-square index. Moreover, subgroup analysis according to types of metabolites was performed. We found a significantly higher odds of diabetes in the highest versus the lowest category of urinary naphthalene (NAP), fluorine (FLU), phenanthrene (PHEN), and total OH-PAH metabolites. The pooled OR (95% CI) was estimated at 1.47 (1.17, 1.78), 1.50 (1.29, 1.71), 1.41 (1.21, 1.60), and 1.61 (1.01, 2.21), respectively. We also found a significant association per 1-fold increase in FLU (OR = 1.09, 95% CI [1.00, 1.19]) and PHEN (OR = 1.19, 95% CI [1.08, 1.30]) metabolites. In subgroup analysis stratified by types of OH-PAH metabolites, A significant stronger odds of diabetes was observed in the highest versus the lowest category of 2-PHEN (OR = 1.66, 95% CI [1.32, 2.00]), 2-NAP (OR = 1.66, 95% CI [1.16, 2.17]), 2-FLU (OR = 1.62, 95% CI [1.28, 1.97]), and 9-FLU (OR = 1.62, 95% CI [1.21, 2.04]) metabolites. Furthermore, there was a meaningfully greater likelihood of diabetes per 1-fold increase in 2-FLU (OR = 1.34, 95% CI [1.10, 1.57]), 2-PHEN (OR = 1.33, 95% CI [1.14, 1.51]), and 3-PHEN (OR = 1.19, 95% CI [1.04, 1.34]) metabolites. In conclusion, our study suggests the significant odds of association between urinary OH-PAH metabolites and diabetes. •OH-PAHs are good biomarkers for assessing population exposure to PAHs.•Studies reported inconsistent results for the association between OH-PAHs and diabetes.•The significant odds of association between OH-PAHs and diabetes was observed.•Longitudinal studies are warranted to confirm the association.
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ISSN:0045-6535
1879-1298
1879-1298
DOI:10.1016/j.chemosphere.2019.125680