Neurocognitive correlates of alexithymia in asymptomatic individuals with HIV

Alexithymia, an impairment of affective and cognitive emotional processing, is often associated with human immunodeficiency virus (HIV) and may reflect effects of the virus on brain areas that are also important for multiple cognitive functions, such as the prefrontal and anterior cingulate cortices...

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Vydané v:	Neuropsychologia Ročník 48; číslo 5; s. 1295 - 1304
Hlavní autori:	Bogdanova, Yelena, Díaz-Santos, Mirella, Cronin-Golomb, Alice
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Kidlington Elsevier Ltd 01.04.2010 Elsevier
Predmet:	Adult and adolescent clinical studies Affective Symptoms - diagnosis Affective Symptoms - epidemiology Affective Symptoms - psychology Anterior cingulate Apathy Biological and medical sciences Brain - physiopathology CD4 Antigens - blood Cognition Cognition Disorders - diagnosis Cognition Disorders - epidemiology Cognition Disorders - physiopathology Emotion Female Frontostriatal HIV Infections - blood HIV Infections - epidemiology Human viral diseases Humans Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology Infectious diseases Male Medical sciences Middle Aged Nadir CD4 cell count Organic mental disorders. Neuropsychology Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Quality of Life - psychology Surveys and Questionnaires Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Apathy Frontostriatal Anterior cingulate Cognition Nadir CD4 cell count Emotion Affect affectivity Central nervous system Asymptomatic Frontal cortex Encephalon Cingulate cortex Human Immunopathology Alexithymia Retroviridae AIDS Basal ganglion Personality Corpus striatum Emotion emotionality Immune deficiency Lentivirus Infection Virus Viral disease Human immunodeficiency virus frontostriatal emotion cognition anterior cingulate nadir CD4 cell count apathy
ISSN:	0028-3932, 1873-3514, 1873-3514
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Shrnutí:	Alexithymia, an impairment of affective and cognitive emotional processing, is often associated with human immunodeficiency virus (HIV) and may reflect effects of the virus on brain areas that are also important for multiple cognitive functions, such as the prefrontal and anterior cingulate cortices. We hypothesized that there would be a correlation between extent of alexithymia and cognitive performance associated with these brain areas, including attention, executive function, and visuospatial processing. Thirty-four asymptomatic HIV+ participants and 34 matched healthy HIV− volunteers were administered the Toronto Alexithymia Scale, a series of neuropsychological tests, and measures of apathy, depression, and quality of life (QoL). The HIV+ participants had significantly higher levels of alexithymia, depression and apathy than the HIV− group. The extent of alexithymia and two of its processing components (Difficulty Describing Feelings [DDF] and Externally Oriented Thinking), but not depression, correlated with performance on measures of executive and visuospatial abilities, consistent with dysfunction of the frontostriatal circuits and their cortical projections. Apathy was related to alexithymia and two processing components (Difficulty Identifying Feelings and DDF) but to only one cognitive measure. The higher rate of alexithymia, as well as cognitive dysfunction, in HIV may be a consequence of the infection on the frontostriatal system and its cortical connections. Our findings also demonstrated a dissociation of apathy and alexithymia in HIV, pointing to overlapping but distinct neural substrates within frontostriatal circuits. Alexithymia correlated strongly with QoL ratings, underscoring the importance of assessment and treatment of HIV-associated emotional and cognitive processing deficits.
Bibliografia:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0028-3932 1873-3514 1873-3514
DOI:	10.1016/j.neuropsychologia.2009.12.033