Boosting the Catalytic Performance of Metal–Organic Frameworks for Steroid Transformations by Confinement within a Mesoporous Scaffold

Solid‐state crystallization achieves selective confinement of metal–organic framework (MOF) nanocrystals within mesoporous materials, thereby rendering active sites more accessible compared to the bulk‐MOF and enhancing the chemical and mechanical stability of MOF nanocrystals. (Zr)UiO‐66(NH2)/SiO2...

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Bibliographic Details
Published in:Angewandte Chemie International Edition Vol. 56; no. 43; pp. 13302 - 13306
Main Authors: Cirujano, Francisco G., Luz, Ignacio, Soukri, Mustapha, Van Goethem, Cedric, Vankelecom, Ivo F. J., Lail, Marty, De Vos, Dirk E.
Format: Journal Article
Language:English
Published: Germany Wiley Subscription Services, Inc 16.10.2017
Edition:International ed. in English
Subjects:
active-site confinement
Catalysis
Catalysts
Catalytic activity
Chemical synthesis
Confinement
Crystallization
Crystals
mesoporous silica
Metal-organic frameworks
MOF composites
Nanocrystals
nanoMOFs
Silicon dioxide
steroid chemistry
Steroids
Transformations
Zirconium
nanoMOFs
steroid chemistry
mesoporous silica
MOF composites
active-site confinement
ISSN:1433-7851, 1521-3773, 1521-3773
Online Access:Get full text
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Summary:Solid‐state crystallization achieves selective confinement of metal–organic framework (MOF) nanocrystals within mesoporous materials, thereby rendering active sites more accessible compared to the bulk‐MOF and enhancing the chemical and mechanical stability of MOF nanocrystals. (Zr)UiO‐66(NH2)/SiO2 hybrid materials were tested as efficient and reusable heterogeneous catalysts for the synthesis of steroid derivatives, outperforming the bulk (Zr)UiO‐66(NH2) MOF. A clear correlation between the catalytic activity of the dispersed Zr sites present in the confined MOF, and the loading of the mesoporous SiO2, is demonstrated for steroid transformations. Sentenced to solitary: Confinement of UiO‐66 metal–organic framework (MOF) nanocrystals inside the pores of SBA‐15 mesoporous silica promotes MOF‐catalyzed transformations of bulky steroids, while simultaneously enhancing the chemical and mechanical stability of the MOF.
Bibliography:These authors contributed equally to this work.
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ISSN:1433-7851
1521-3773
1521-3773
DOI:10.1002/anie.201706721