Crosstalk between AML and stromal cells triggers acetate secretion through the metabolic rewiring of stromal cells

Acute myeloid leukaemia (AML) cells interact and modulate components of their surrounding microenvironment into their own benefit. Stromal cells have been shown to support AML survival and progression through various mechanisms. Nonetheless, whether AML cells could establish beneficial metabolic int...

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Bibliographic Details
Published in:	eLife Vol. 11
Main Authors:	Vilaplana-Lopera, Nuria, Cuminetti, Vincent, Almaghrabi, Ruba, Papatzikas, Grigorios, Rout, Ashok Kumar, Jeeves, Mark, González, Elena, Alyahyawi, Yara, Cunningham, Alan, Erdem, Ayşegül, Schnütgen, Frank, Raghavan, Manoj, Potluri, Sandeep, Cazier, Jean-Baptiste, Schuringa, Jan Jacob, Reed, Michelle AC, Arranz, Lorena, Günther, Ulrich L, Garcia, Paloma
Format:	Journal Article
Language:	English
Published:	England eLife Sciences Publications Ltd 02.09.2022 eLife Sciences Publications, Ltd
Subjects:	Acetates Acetic acid acute myeloid leukaemia Acute myeloid leukemia Animals Biochemistry and Chemical Biology Bone marrow Cancer Biology Cell interactions Cell lines Experiments Gap junctions Glucose Glycolysis human Humans Leukemia, Myeloid, Acute - metabolism Lipids Metabolism Metabolites Mice microenvironment Microenvironments mouse NMR Nuclear magnetic resonance Pyruvates Pyruvic acid Reactive oxygen species Reactive Oxygen Species - metabolism Signal Transduction Standard deviation Stromal cells Stromal Cells - metabolism Transcriptomes Tricarboxylic acid cycle Tumor Microenvironment microenvironment mouse chemical biology acute myeloid leukaemia biochemistry cancer biology metabolism human nuclear magnetic resonance
ISSN:	2050-084X, 2050-084X
Online Access:	Get full text
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