Mouse LYVE-1 is an endocytic receptor for hyaluronan in lymphatic endothelium

The glycosaminoglycan hyaluronan is a key substrate for cell migration in tissues during inflammation, wound healing, and neoplasia. Unlike other matrix components, hyaluronan (HA) is turned over rapidly, yet most degradation occurs not locally but within distant lymph nodes, through mechanisms that...

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Bibliographic Details
Published in:	The Journal of biological chemistry Vol. 276; no. 22; p. 19420
Main Authors:	Prevo, R, Banerji, S, Ferguson, D J, Clasper, S, Jackson, D G
Format:	Journal Article
Language:	English
Published:	United States 01.06.2001
Subjects:	Amino Acid Sequence Animals Base Sequence Biotinylation Blotting, Northern Cell Line Cell Movement Cloning, Molecular Databases, Factual Dose-Response Relationship, Drug Endothelium - metabolism Endothelium, Vascular - metabolism Expressed Sequence Tags Female Fibroblasts - metabolism Glycoproteins - chemistry Glycoproteins - genetics Glycoproteins - physiology Glycosaminoglycans - metabolism Humans Hyaluronan Receptors - genetics Hyaluronan Receptors - metabolism Hyaluronic Acid - metabolism Hyaluronic Acid - pharmacokinetics Lymph Nodes - metabolism Lymphangioma - metabolism Membrane Transport Proteins Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Knockout Microscopy, Fluorescence Microscopy, Immunoelectron Molecular Sequence Data Neoplasm Transplantation Plasmids - metabolism Protein Binding Recombinant Fusion Proteins - metabolism RNA, Messenger - metabolism Sequence Homology, Amino Acid Tissue Distribution Transfection Vesicular Transport Proteins
ISSN:	0021-9258
Online Access:	Get more information
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