Enterococcus faecium: evolution, adaptation, pathogenesis and emerging therapeutics

The opportunistic pathogen Enterococcus faecium colonizes humans and a wide range of animals, endures numerous stresses, resists antibiotic treatment and stubbornly persists in clinical environments. The widespread application of antibiotics in hospitals and agriculture has contributed to the emerge...

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Vydáno v:Nature reviews. Microbiology Ročník 22; číslo 11; s. 705 - 721
Hlavní autoři: Wei, Yahan, Palacios Araya, Dennise, Palmer, Kelli L
Médium: Journal Article
Jazyk:angličtina
Vydáno: England Nature Publishing Group 01.11.2024
Témata:
Adaptation
Adaptation, Physiological
Animals
Anti-Bacterial Agents - pharmacology
Anti-Bacterial Agents - therapeutic use
Antibiotic resistance
Antibiotics
Biological Evolution
Colonization
Enterococcus faecium
Enterococcus faecium - drug effects
Enterococcus faecium - genetics
Enterococcus faecium - physiology
Evolution
Genes
Genomes
Genomics
Gram-positive bacteria
Gram-Positive Bacterial Infections - drug therapy
Gram-Positive Bacterial Infections - microbiology
Hospitals
Humans
Mutation
Nosocomial infection
Nosocomial infections
Opportunist infection
Pathogenesis
Pathogens
Phylogenetics
Vancomycin
Vancomycin Resistance
ISSN:1740-1526, 1740-1534, 1740-1534
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Shrnutí:The opportunistic pathogen Enterococcus faecium colonizes humans and a wide range of animals, endures numerous stresses, resists antibiotic treatment and stubbornly persists in clinical environments. The widespread application of antibiotics in hospitals and agriculture has contributed to the emergence of vancomycin-resistant E. faecium, which causes many hospital-acquired infections. In this Review, we explore recent discoveries about the evolutionary history, the environmental adaptation and the colonization and dissemination mechanisms of E. faecium and vancomycin-resistant E. faecium. These studies provide critical insights necessary for developing novel preventive and therapeutic approaches against vancomycin-resistant E. faecium and also reveal the intricate interrelationships between the environment, the microorganism and the host, providing knowledge that is broadly relevant to how antibiotic-resistant pathogens emerge and endure.
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ISSN:1740-1526
1740-1534
1740-1534
DOI:10.1038/s41579-024-01058-6