Enterococcus faecium: evolution, adaptation, pathogenesis and emerging therapeutics

The opportunistic pathogen Enterococcus faecium colonizes humans and a wide range of animals, endures numerous stresses, resists antibiotic treatment and stubbornly persists in clinical environments. The widespread application of antibiotics in hospitals and agriculture has contributed to the emerge...

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Veröffentlicht in:Nature reviews. Microbiology Jg. 22; H. 11; S. 705 - 721
Hauptverfasser: Wei, Yahan, Palacios Araya, Dennise, Palmer, Kelli L.
Format: Journal Article
Sprache:Englisch
Veröffentlicht: London Nature Publishing Group UK 01.11.2024
Nature Publishing Group
Schlagworte:
631/326/22/1434
631/326/41/2530
631/326/41/2531
631/326/421
Adaptation
Adaptation, Physiological
Animals
Anti-Bacterial Agents - pharmacology
Anti-Bacterial Agents - therapeutic use
Antibiotic resistance
Antibiotics
Biological Evolution
Biomedical and Life Sciences
Colonization
Enterococcus faecium
Enterococcus faecium - drug effects
Enterococcus faecium - genetics
Enterococcus faecium - physiology
Evolution
Genes
Genomes
Genomics
Gram-positive bacteria
Gram-Positive Bacterial Infections - drug therapy
Gram-Positive Bacterial Infections - microbiology
Hospitals
Humans
Infectious Diseases
Life Sciences
Medical Microbiology
Microbiology
Mutation
Nosocomial infection
Nosocomial infections
Opportunist infection
Parasitology
Pathogenesis
Pathogens
Phylogenetics
Review Article
Vancomycin
Vancomycin Resistance
Virology
ISSN:1740-1526, 1740-1534, 1740-1534
Online-Zugang:Volltext
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Zusammenfassung:The opportunistic pathogen Enterococcus faecium colonizes humans and a wide range of animals, endures numerous stresses, resists antibiotic treatment and stubbornly persists in clinical environments. The widespread application of antibiotics in hospitals and agriculture has contributed to the emergence of vancomycin-resistant E.   faecium , which causes many hospital-acquired infections. In this Review, we explore recent discoveries about the evolutionary history, the environmental adaptation and the colonization and dissemination mechanisms of E.   faecium and vancomycin-resistant E.   faecium . These studies provide critical insights necessary for developing novel preventive and therapeutic approaches against vancomycin-resistant E.   faecium and also reveal the intricate interrelationships between the environment, the microorganism and the host, providing knowledge that is broadly relevant to how antibiotic-resistant pathogens emerge and endure. This Review explores recent insights into the evolutionary history, the environmental adaptation and the colonization and dissemination mechanisms of Enterococcus faecium , and highlight potential novel preventative and therapeutic approaches to its infections.
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Y.W. and K.L.P. researched data for the article. Y.W. and K.L.P. contributed substantially to the discussion of the content. Y.W. and K.L.P. wrote the article. D.P.A. contributed to the editing to the first draft of the manuscript. All authors reviewed and/or edited the manuscript before submission.
Author contributions
ISSN:1740-1526
1740-1534
1740-1534
DOI:10.1038/s41579-024-01058-6