Causes of death identified in neonates enrolled through Child Health and Mortality Prevention Surveillance (CHAMPS), December 2016 –December 2021

Each year, 2.4 million children die within their first month of life. Child Health and Mortality Prevention Surveillance (CHAMPS) established in 7 countries aims to generate accurate data on why such deaths occur and inform prevention strategies. Neonatal deaths that occurred between December 2016 a...

Celý popis

Uloženo v:

Podrobná bibliografie
Vydáno v:	PLOS global public health Ročník 3; číslo 3; s. e0001612
Hlavní autoři:	Mahtab, Sana, Madhi, Shabir A., Baillie, Vicky L., Els, Toyah, Thwala, Bukiwe Nana, Onyango, Dickens, Tippet-Barr, Beth A., Akelo, Victor, Igunza, Kitiezo Aggrey, Omore, Richard, Arifeen, Shams El, Gurley, Emily S., Alam, Muntasir, Chowdhury, Atique Iqbal, Rahman, Afruna, Bassat, Quique, Mandomando, Inacio, Ajanovic, Sara, Sitoe, Antonio, Varo, Rosauro, Sow, Samba O., Kotloff, Karen L., Badji, Henry, Tapia, Milagritos D., Traore, Cheick B., Ogbuanu, Ikechukwu U., Bunn, James, Luke, Ronita, Sannoh, Sulaiman, Swarray-Deen, Alim, Assefa, Nega, Scott, J. Anthony G., Madrid, Lola, Marami, Dadi, Fentaw, Surafel, Diaz, Maureen H., Martines, Roosecelis B., Breiman, Robert F., Madewell, Zachary J., Blau, Dianna M., Whitney, Cynthia G.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States Public Library of Science 20.03.2023 Public Library of Science (PLoS)
Témata:	Biology and Life Sciences Medicine and Health Sciences
ISSN:	2767-3375, 2767-3375
On-line přístup:	Získat plný text
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!

Popis
Shrnutí:	Each year, 2.4 million children die within their first month of life. Child Health and Mortality Prevention Surveillance (CHAMPS) established in 7 countries aims to generate accurate data on why such deaths occur and inform prevention strategies. Neonatal deaths that occurred between December 2016 and December 2021 were investigated with MITS within 24–72 hours of death. Testing included blood, cerebrospinal fluid and lung cultures, multi-pathogen PCR on blood, CSF, nasopharyngeal swabs and lung tissue, and histopathology examination of lung, liver and brain. Data collection included clinical record review and family interview using standardized verbal autopsy. The full set of data was reviewed by local experts using a standardized process (Determination of Cause of Death) to identify all relevant conditions leading to death (causal chain), per WHO recommendations. For analysis we stratified neonatal death into 24-hours of birth, early (1-<7 days) and late (7-<28 days) neonatal deaths. We analyzed 1458 deaths, 41% occurring within 24-hours, 41% early and 18% late neonatal deaths. Leading underlying causes of death were complications of intrapartum events (31%), complications of prematurity (28%), infections (17%), respiratory disorders (11%), and congenital malformations (8%). In addition to the underlying cause, 62% of deaths had additional conditions and 14% had ≥3 other conditions in the causal chain. The most common causes considering the whole causal chain were infection (40%), prematurity (32%) and respiratory distress syndrome (28%). Common maternal conditions linked to neonatal death were maternal hypertension (10%), labour and delivery complications (8%), multiple gestation (7%), placental complications (6%) obstructed labour and chorioamnionitis (5%, each). CHAMPS’ findings showing the full causal chain of events that lead to death, in addition to maternal factors, highlights the complexities involved in each death along with the multiple opportunities for prevention. Highlighting improvements to prenatal and obstetric care and infection prevention are urgently needed in high-mortality settings.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Membership of CHAMPS Consortium is provided in S1 Text. The authors have declared that no competing interests exist.
ISSN:	2767-3375 2767-3375
DOI:	10.1371/journal.pgph.0001612