Antagonistic circuits mediating infanticide and maternal care in female mice

In many species, including mice, female animals show markedly different pup-directed behaviours based on their reproductive state 1 , 2 . Naive wild female mice often kill pups, while lactating female mice are dedicated to pup caring 3 , 4 . The neural mechanisms that mediate infanticide and its swi...

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Vydané v:	Nature (London) Ročník 618; číslo 7967; s. 1006 - 1016
Hlavní autori:	Mei, Long, Yan, Rongzhen, Yin, Luping, Sullivan, Regina M., Lin, Dayu
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	London Nature Publishing Group UK 29.06.2023 Nature Publishing Group
Predmet:	13/51 631/378/3919 631/378/3920 64/60 9/74 Animals Behavior Brain ESR1 protein Estrogen receptors Excitability Female Females Humanities and Social Sciences Hypothalamus Hypotheses Infanticide Laboratories Lactation Maternal behavior Maternal Behavior - physiology Mice multidisciplinary Neural Pathways - physiology Preoptic area Preoptic area (medial) Preoptic Area - cytology Preoptic Area - physiology Reproductive behavior Science Science (multidisciplinary) Stria terminalis Thalamus - cytology Thalamus - physiology
ISSN:	0028-0836, 1476-4687, 1476-4687
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Shrnutí:	In many species, including mice, female animals show markedly different pup-directed behaviours based on their reproductive state 1 , 2 . Naive wild female mice often kill pups, while lactating female mice are dedicated to pup caring 3 , 4 . The neural mechanisms that mediate infanticide and its switch to maternal behaviours during motherhood remain unclear. Here, on the basis of the hypothesis that maternal and infanticidal behaviours are supported by distinct and competing neural circuits 5 , 6 , we use the medial preoptic area (MPOA), a key site for maternal behaviours 7 – 11 , as a starting point and identify three MPOA-connected brain regions that drive differential negative pup-directed behaviours. Functional manipulation and in vivo recording reveal that oestrogen receptor α (ESR1)-expressing cells in the principal nucleus of the bed nucleus of stria terminalis (BNSTpr ESR1 ) are necessary, sufficient and naturally activated during infanticide in female mice. MPOA ESR1 and BNSTpr ESR1 neurons form reciprocal inhibition to control the balance between positive and negative infant-directed behaviours. During motherhood, MPOA ESR1 and BNSTpr ESR1 cells change their excitability in opposite directions, supporting a marked switch of female behaviours towards the young. ESR1-expressing cells in the principal nucleus of the bed nucleus of stria terminalis are necessary, sufficient and naturally activated during infanticide, and they form reciprocal inhibition with the maternal cells to control young-directed behaviours in female mice.
Bibliografia:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Author Contribution statement Equal contribution D.L. and M.L. conceived the project, designed experiments, analyzed data and wrote the paper. D.L. supervised the project. M.L. performed most experiments and prepared figures. R.Y. and L.Y. performed slice recording experiments and prepared related figures. R.S. provided critical feedback on the experiments.
ISSN:	0028-0836 1476-4687 1476-4687
DOI:	10.1038/s41586-023-06147-9