Randomization in clinical studies

Randomized controlled trial is widely accepted as the best design for evaluating the efficacy of a new treatment because of the advantages of randomization (random allocation). Randomization eliminates accidental bias, including selection bias, and provides a base for allowing the use of probability...

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Veröffentlicht in:Korean journal of anesthesiology Jg. 72; H. 3; S. 221 - 232
Hauptverfasser: Lim, Chi-Yeon, In, Junyong
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Korea (South) Korean Society of Anesthesiologists 01.06.2019
대한마취통증의학회
Schlagworte:
adaptive randomization
Bias
Humans
minimization
Random Allocation
randomization
randomized controlled trial
Randomized Controlled Trials as Topic - statistics & numerical data
Research Design
restrictive randomization
Selection Bias
simple randomization
Statistical Round
stratified randomization
마취과학
Randomization
Simple randomization
Restrictive randomization
Adaptive randomization
Minimization
Random allocation
Randomized controlled trial
ISSN:2005-6419, 2005-7563, 2005-7563
Online-Zugang:Volltext
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Beschreibung
Zusammenfassung:Randomized controlled trial is widely accepted as the best design for evaluating the efficacy of a new treatment because of the advantages of randomization (random allocation). Randomization eliminates accidental bias, including selection bias, and provides a base for allowing the use of probability theory. Despite its importance, randomization has not been properly understood. This article introduces the different randomization methods with examples: simple randomization; block randomization; adaptive randomization, including minimization; and response-adaptive randomization. Ethics related to randomization are also discussed. The study is helpful in understanding the basic concepts of randomization and how to use R software.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
ISSN:2005-6419
2005-7563
2005-7563
DOI:10.4097/kja.19049