Identification of EMT signaling cross-talk and gene regulatory networks by single-cell RNA sequencing

The epithelial-to-mesenchymal transition (EMT) plays a critical role during normal development and in cancer progression. EMT is induced by various signaling pathways, including TGF-β, BMP, Wnt-β-catenin, NOTCH, Shh, and receptor tyrosine kinases. In this study, we performed single-cell RNA sequenci...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS Jg. 118; H. 19
Hauptverfasser:	Deshmukh, Abhijeet P, Vasaikar, Suhas V, Tomczak, Katarzyna, Tripathi, Shubham, den Hollander, Petra, Arslan, Emre, Chakraborty, Priyanka, Soundararajan, Rama, Jolly, Mohit Kumar, Rai, Kunal, Levine, Herbert, Mani, Sendurai A
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 11.05.2021
Schlagworte:	Cell Line Epithelial Cells - drug effects Epithelial Cells - metabolism Epithelial-Mesenchymal Transition - drug effects Epithelial-Mesenchymal Transition - genetics Gene Expression Profiling - methods Gene Expression Profiling - statistics & numerical data Gene Regulatory Networks Humans Kaplan-Meier Estimate MicroRNAs - genetics Neoplasms - classification Neoplasms - genetics Prognosis Proportional Hazards Models RNA-Seq - methods Signal Transduction - drug effects Signal Transduction - genetics Single-Cell Analysis - methods Transforming Growth Factor beta1 - metabolism Transforming Growth Factor beta1 - pharmacology NOTCH scRNA-seq RACIPE signaling cascade EMT
ISSN:	1091-6490, 1091-6490
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