Obesity-induced extracellular vesicles proteins drive the endometrial cancer pathogenesis: therapeutic potential of HO-3867 and Metformin

Endometrial cancer (EC) is the leading gynecologic malignancy in the United States with obesity implicated in 57% of cases. This research investigates the molecular complexities of extracellular vesicles (EV) secretion as carriers of oncogenic protein and their involvement in obesity-mediated EC. An...

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Bibliographic Details
Published in:	Oncogene Vol. 43; no. 49; pp. 3586 - 3597
Main Authors:	Sakaue, Takahiko, Dorayappan, Kalpana Deepa Priya, Zingarelli, Roman, Khadraoui, Wafa, Anbalagan, Muralidharan, Wallbillich, John, Bognar, Balazs, Wanner, Ross, Cosgrove, Casey, Suarez, Adrian, Koga, Hironori, Maxwell, G. Larry, O’Malley, David M., Cohn, David E., Selvendiran, Karuppaiyah
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 27.11.2024 Nature Publishing Group
Subjects:	631/67 631/67/1517/1709 Adipocytes Adipose tissue Animals Antidiabetics Apoptosis Body fat Body weight Cell Biology Cell growth Cell Line, Tumor Cell migration Cell proliferation Cell Proliferation - drug effects Diet, High-Fat - adverse effects Endometrial cancer Endometrial Neoplasms - drug therapy Endometrial Neoplasms - metabolism Endometrial Neoplasms - pathology Endometrium Extracellular vesicles Extracellular Vesicles - metabolism Female High fat diet Human Genetics Humans Hyperplasia Internal Medicine Malignancy Medicine Medicine & Public Health Metformin Metformin - pharmacology Metformin - therapeutic use Mice Obesity Obesity - drug therapy Obesity - metabolism Oncology Pathogenesis Patients Protein expression Proteins Secretion Stat5 protein Tumor suppressor genes Tumors Uterine cancer Uterus
ISSN:	0950-9232, 1476-5594, 1476-5594
Online Access:	Get full text
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