Clinical implications of T cell exhaustion for cancer immunotherapy

Immunotherapy has been a remarkable clinical advancement in the treatment of cancer. T cells are pivotal to the efficacy of current cancer immunotherapies, including immune-checkpoint inhibitors and adoptive cell therapies. However, cancer is associated with T cell exhaustion, a hypofunctional state...

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Bibliographic Details
Published in:	Nature reviews. Clinical oncology Vol. 19; no. 12; pp. 775 - 790
Main Authors:	Chow, Andrew, Perica, Karlo, Klebanoff, Christopher A, Wolchok, Jedd D
Format:	Journal Article
Language:	English
Published:	England Nature Publishing Group 01.12.2022
Subjects:	Antigens Cancer Cancer immunotherapy Chronic exposure Clinical outcomes Epigenetics Humans Immune Checkpoint Inhibitors Immunotherapy Immunotherapy, Adoptive Lymphocytes Lymphocytes T Microenvironments Neoplasms Reviews T-Lymphocytes Tumor Microenvironment Tumors
ISSN:	1759-4774, 1759-4782, 1759-4782
Online Access:	Get full text
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