Therapeutic induction of antigen-specific immune tolerance

The development of therapeutic approaches for the induction of robust, long-lasting and antigen-specific immune tolerance remains an important unmet clinical need for the management of autoimmunity, allergy, organ transplantation and gene therapy. Recent breakthroughs in our understanding of immune...

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Bibliographic Details
Published in:Nature reviews. Immunology Vol. 24; no. 5; pp. 338 - 357
Main Authors: Kenison, Jessica E, Stevens, Nikolas A, Quintana, Francisco J
Format: Journal Article
Language:English
Published: England Nature Publishing Group 01.05.2024
Subjects:
Allergies
Animals
Antigens
Antigens - immunology
Apoptosis
Autoimmune diseases
Autoimmune Diseases - immunology
Autoimmune Diseases - therapy
Autoimmunity
Autoimmunity - immunology
Bone marrow
Cell death
Cloning
Cytokines
Gene therapy
Humans
Immune Tolerance - immunology
Immunological tolerance
Immunology
Lymphocytes
Organ Transplantation
Peptides
Thymus gland
Transcription factors
Transplantation
Transplants & implants
Tumor necrosis factor-TNF
ISSN:1474-1733, 1474-1741, 1474-1741
Online Access:Get full text
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Summary:The development of therapeutic approaches for the induction of robust, long-lasting and antigen-specific immune tolerance remains an important unmet clinical need for the management of autoimmunity, allergy, organ transplantation and gene therapy. Recent breakthroughs in our understanding of immune tolerance mechanisms have opened new research avenues and therapeutic opportunities in this area. Here, we review mechanisms of immune tolerance and novel methods for its therapeutic induction.
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ISSN:1474-1733
1474-1741
1474-1741
DOI:10.1038/s41577-023-00970-x