Integration of mass cytometry and mass spectrometry imaging for spatially resolved single-cell metabolic profiling

The integration of spatial omics technologies can provide important insights into the biology of tissues. Here we combined mass spectrometry imaging-based metabolomics and imaging mass cytometry-based immunophenotyping on a single tissue section to reveal metabolic heterogeneity at single-cell resol...

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Bibliographic Details
Published in:	Nature methods Vol. 21; no. 10; pp. 1796 - 1800
Main Authors:	Nunes, Joana B., Ijsselsteijn, Marieke E., Abdelaal, Tamim, Ursem, Rick, van der Ploeg, Manon, Giera, Martin, Everts, Bart, Mahfouz, Ahmed, Heijs, Bram, de Miranda, Noel F. C. C.
Format:	Journal Article
Language:	English
Published:	New York Nature Publishing Group US 01.10.2024 Nature Publishing Group
Subjects:	631/1647/1407/1492 631/1647/245 631/1647/296 631/1647/320 631/67/2327 Bioinformatics Biological Microscopy Biological Techniques Biomedical and Life Sciences Biomedical Engineering/Biotechnology Brief Communication Cancer Cells Cytometry Heterogeneity Immune system Life Sciences Mass spectrometry Mass spectroscopy Medical imaging Metabolism Metabolites Metabolomics Proteomics Scientific imaging Workflow
ISSN:	1548-7091, 1548-7105, 1548-7105
Online Access:	Get full text
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