Analysis of pulsed cisplatin signalling dynamics identifies effectors of resistance in lung adenocarcinoma

The identification of clinically viable strategies for overcoming resistance to platinum chemotherapy in lung adenocarcinoma has previously been hampered by inappropriately tailored in vitro assays of drug response. Therefore, using a pulse model that closely mimics the in vivo pharmacokinetics of p...

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Bibliographic Details
Published in:	eLife Vol. 9
Main Authors:	Hastings, Jordan F, Gonzalez Rajal, Alvaro, Latham, Sharissa L, Han, Jeremy ZR, McCloy, Rachael A, O'Donnell, Yolande EI, Phimmachanh, Monica, Murphy, Alexander D, Nagrial, Adnan, Daneshvar, Dariush, Chin, Venessa, Watkins, D Neil, Burgess, Andrew, Croucher, David R
Format:	Journal Article
Language:	English
Published:	England eLife Sciences Publications Ltd 09.06.2020 eLife Sciences Publications, Ltd
Subjects:	Adenocarcinoma Adenocarcinoma of Lung - metabolism Adenocarcinoma of Lung - pathology Antibodies Antineoplastic Agents - pharmacology Apoptosis Apoptosis - drug effects Cancer Biology Cancer therapies Cell cycle Cell Cycle - drug effects Cell Line, Tumor chemoresistance Chemotherapy Cisplatin Cisplatin - pharmacology Deoxyribonucleic acid Dimensional analysis DNA DNA damage Drug dosages Drug Resistance, Neoplasm Humans Investigations lung adenocarcinoma Lung cancer Lung Neoplasms - metabolism Lung Neoplasms - pathology Mutation p53 p53 Protein P70S6K Pharmacokinetics Physiology Platinum platinum chemotherapy Proteins Response rates Signal Transduction - drug effects signalling dynamics Tumor cell lines chemoresistance signalling dynamics lung adenocarcinoma cancer biology human platinum chemotherapy P70S6K p53
ISSN:	2050-084X, 2050-084X
Online Access:	Get full text
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