The genomic basis of childhood T-lineage acute lymphoblastic leukaemia

T-lineage acute lymphoblastic leukaemia (T-ALL) is a high-risk tumour 1 that has eluded comprehensive genomic characterization, which is partly due to the high frequency of noncoding genomic alterations that result in oncogene deregulation 2 , 3 . Here we report an integrated analysis of genome and...

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Veröffentlicht in:	Nature (London) Jg. 632; H. 8027; S. 1082 - 1091
Hauptverfasser:	Pölönen, Petri, Di Giacomo, Danika, Seffernick, Anna Eames, Elsayed, Abdelrahman, Kimura, Shunsuke, Benini, Francesca, Montefiori, Lindsey E., Wood, Brent L., Xu, Jason, Chen, Changya, Cheng, Zhongshan, Newman, Haley, Myers, Jason, Iacobucci, Ilaria, Li, Elizabeth, Sussman, Jonathan, Hedges, Dale, Hui, Yawei, Diorio, Caroline, Uppuluri, Lahari, Frank, David, Fan, Yiping, Chang, Yunchao, Meshinchi, Soheil, Ries, Rhonda, Shraim, Rawan, Li, Alexander, Bernt, Kathrin M., Devidas, Meenakshi, Winter, Stuart S., Dunsmore, Kimberly P., Inaba, Hiroto, Carroll, William L., Ramirez, Nilsa C., Phillips, Aaron H., Kriwacki, Richard W., Yang, Jun J., Vincent, Tiffaney L., Zhao, Yaqi, Ghate, Pankaj S., Wang, Jian, Reilly, Colleen, Zhou, Xin, Sanders, Mathijs A., Takita, Junko, Kato, Motohiro, Takasugi, Nao, Chang, Bill H., Press, Richard D., Loh, Mignon, Rampersaud, Evadnie, Raetz, Elizabeth, Hunger, Stephen P., Tan, Kai, Chang, Ti-Cheng, Wu, Gang, Pounds, Stanley B., Mullighan, Charles G., Teachey, David T.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 29.08.2024 Nature Publishing Group
Schlagworte:	38 38/91 45 631/114/2401 631/67/1990/283/2125 631/67/68 631/67/69 Acute lymphoblastic leukemia Cell culture Child Childhood Children Chromatin Chromatin - genetics Chromatin - metabolism Deregulation Enhancer Elements, Genetic - genetics Enhancers Epigenomics Female Gene expression Gene Expression Regulation, Leukemic Gene sequencing Genes Genetic diversity Genome, Human - genetics Genomes Genomic analysis Genomics Hematopoietic stem cells Humanities and Social Sciences Humans Leukemia Lymphocytes Lymphocytes T Male Medical prognosis multidisciplinary Mutation Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - genetics Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - pathology Precursors Remission Science Science (multidisciplinary) Single-Cell Analysis Stem cells T cell receptors T-Lymphocytes - cytology T-Lymphocytes - pathology Topology Transcriptome - genetics Transcriptomes
ISSN:	0028-0836, 1476-4687, 1476-4687
Online-Zugang:	Volltext
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