B-cell-specific checkpoint molecules that regulate anti-tumour immunity
The role of B cells in anti-tumour immunity is still debated and, accordingly, immunotherapies have focused on targeting T and natural killer cells to inhibit tumour growth 1 , 2 . Here, using high-throughput flow cytometry as well as bulk and single-cell RNA-sequencing and B-cell-receptor-sequencin...
Gespeichert in:
| Veröffentlicht in: | Nature (London) Jg. 619; H. 7969; S. 348 - 356 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format: | Journal Article |
| Sprache: | Englisch |
| Veröffentlicht: |
London
Nature Publishing Group UK
13.07.2023
Nature Publishing Group |
| Schlagworte: | |
| ISSN: | 0028-0836, 1476-4687, 1476-4687 |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| Abstract | The role of B cells in anti-tumour immunity is still debated and, accordingly, immunotherapies have focused on targeting T and natural killer cells to inhibit tumour growth
1
,
2
. Here, using high-throughput flow cytometry as well as bulk and single-cell RNA-sequencing and B-cell-receptor-sequencing analysis of B cells temporally during B16F10 melanoma growth, we identified a subset of B cells that expands specifically in the draining lymph node over time in tumour-bearing mice. The expanding B cell subset expresses the cell surface molecule T cell immunoglobulin and mucin domain 1 (TIM-1, encoded by
Havcr1
) and a unique transcriptional signature, including multiple co-inhibitory molecules such as PD-1, TIM-3, TIGIT and LAG-3. Although conditional deletion of these co-inhibitory molecules on B cells had little or no effect on tumour burden, selective deletion of
Havcr1
in B cells both substantially inhibited tumour growth and enhanced effector T cell responses. Loss of TIM-1 enhanced the type 1 interferon response in B cells, which augmented B cell activation and increased antigen presentation and co-stimulation, resulting in increased expansion of tumour-specific effector T cells. Our results demonstrate that manipulation of TIM-1-expressing B cells enables engagement of the second arm of adaptive immunity to promote anti-tumour immunity and inhibit tumour growth.
Manipulation of TIM-1-expressing B cells enables engagement of the second arm of adaptive immunity to promote anti-tumour immunity and inhibit tumour growth. |
|---|---|
| AbstractList | The role ofB cells in anti-tumour immunity is still debated and, accordingly, immunotherapies have focused on targeting T and natural killer cells to inhibit tumour growth1,2. Here, using high-throughput flow cytometry as well as bulk and single-cell RNA-sequencing and B-cell-receptor-sequencing analysis ofB cells temporally during B16F10 melanoma growth, we identified a subset of B cells that expands specifically in the draining lymph node over time in tumour-bearing mice. The expanding B cell subset expresses the cell surface molecule T cell immunoglobulin and mucin domain 1 (TIM-1, encoded by Haveri) and a unique transcriptional signature, including multiple co-inhibitory molecules such as PD-1, TIM-3, TIGIT and LAG-3. Although conditional deletion ofthese co-inhibitory molecules on B cells had little or no effect on tumour burden, selective deletion of Haveri in B cells both substantially inhibited tumour growth and enhanced effector T cell responses. Loss of TIM-1 enhanced the type 1 interferon response in B cells, which augmented B cell activation and increased antigen presentation and co-stimulation, resulting in increased expansion of tumour-specific effector T cells. Our results demonstrate that manipulation of TIM-1-expressing B cells enables engagement of the second arm of adaptive immunity to promote anti-tumour immunity and inhibit tumour growth. The role of B cells in anti-tumor immunity is still debated and accordingly, immunotherapies have focused on targeting T and NK cells to inhibit tumor growth1,2. Here, using high-throughput flow cytometry, bulk and single-cell RNA- and BCR-sequencing of B cells temporally during B16F10 melanoma growth, we identified a subset of B cells that expands specifically in the draining lymph node over time in tumor bearing-mice. The expanding B cell subset expresses the cell surface molecule T cell immunoglobulin and mucin domain 1 (TIM-1) and a unique transcriptional signature, including multiple co-inhibitory molecules such as PD-1, TIM-3, TIGIT and LAG-3. While conditional deletion of these co-inhibitory molecules on B cells had little or no effect on tumor burden, selective deletion of Havcr1 (the gene encoding TIM-1) in B cells both dramatically inhibited tumor growth and enhanced effector T cell responses. Loss of TIM-1 enhanced the type 1 interferon response in B cells, which augmented B cell activation and increased antigen presentation and co-stimulation, resulting in increased expansion of tumor-specific effector T cells. Our results demonstrate that manipulation of TIM-1-expressing B cells enables engagement of the second arm of adaptive immunity to promote anti-tumor immunity and inhibit tumor growth. The role of B cells in anti-tumour immunity is still debated and, accordingly, immunotherapies have focused on targeting T and natural killer cells to inhibit tumour growth . Here, using high-throughput flow cytometry as well as bulk and single-cell RNA-sequencing and B-cell-receptor-sequencing analysis of B cells temporally during B16F10 melanoma growth, we identified a subset of B cells that expands specifically in the draining lymph node over time in tumour-bearing mice. The expanding B cell subset expresses the cell surface molecule T cell immunoglobulin and mucin domain 1 (TIM-1, encoded by Havcr1) and a unique transcriptional signature, including multiple co-inhibitory molecules such as PD-1, TIM-3, TIGIT and LAG-3. Although conditional deletion of these co-inhibitory molecules on B cells had little or no effect on tumour burden, selective deletion of Havcr1 in B cells both substantially inhibited tumour growth and enhanced effector T cell responses. Loss of TIM-1 enhanced the type 1 interferon response in B cells, which augmented B cell activation and increased antigen presentation and co-stimulation, resulting in increased expansion of tumour-specific effector T cells. Our results demonstrate that manipulation of TIM-1-expressing B cells enables engagement of the second arm of adaptive immunity to promote anti-tumour immunity and inhibit tumour growth. The role of B cells in anti-tumour immunity is still debated and, accordingly, immunotherapies have focused on targeting T and natural killer cells to inhibit tumour growth1,2. Here, using high-throughput flow cytometry as well as bulk and single-cell RNA-sequencing and B-cell-receptor-sequencing analysis of B cells temporally during B16F10 melanoma growth, we identified a subset of B cells that expands specifically in the draining lymph node over time in tumour-bearing mice. The expanding B cell subset expresses the cell surface molecule T cell immunoglobulin and mucin domain 1 (TIM-1, encoded by Havcr1) and a unique transcriptional signature, including multiple co-inhibitory molecules such as PD-1, TIM-3, TIGIT and LAG-3. Although conditional deletion of these co-inhibitory molecules on B cells had little or no effect on tumour burden, selective deletion of Havcr1 in B cells both substantially inhibited tumour growth and enhanced effector T cell responses. Loss of TIM-1 enhanced the type 1 interferon response in B cells, which augmented B cell activation and increased antigen presentation and co-stimulation, resulting in increased expansion of tumour-specific effector T cells. Our results demonstrate that manipulation of TIM-1-expressing B cells enables engagement of the second arm of adaptive immunity to promote anti-tumour immunity and inhibit tumour growth.The role of B cells in anti-tumour immunity is still debated and, accordingly, immunotherapies have focused on targeting T and natural killer cells to inhibit tumour growth1,2. Here, using high-throughput flow cytometry as well as bulk and single-cell RNA-sequencing and B-cell-receptor-sequencing analysis of B cells temporally during B16F10 melanoma growth, we identified a subset of B cells that expands specifically in the draining lymph node over time in tumour-bearing mice. The expanding B cell subset expresses the cell surface molecule T cell immunoglobulin and mucin domain 1 (TIM-1, encoded by Havcr1) and a unique transcriptional signature, including multiple co-inhibitory molecules such as PD-1, TIM-3, TIGIT and LAG-3. Although conditional deletion of these co-inhibitory molecules on B cells had little or no effect on tumour burden, selective deletion of Havcr1 in B cells both substantially inhibited tumour growth and enhanced effector T cell responses. Loss of TIM-1 enhanced the type 1 interferon response in B cells, which augmented B cell activation and increased antigen presentation and co-stimulation, resulting in increased expansion of tumour-specific effector T cells. Our results demonstrate that manipulation of TIM-1-expressing B cells enables engagement of the second arm of adaptive immunity to promote anti-tumour immunity and inhibit tumour growth. The role of B cells in anti-tumour immunity is still debated and, accordingly, immunotherapies have focused on targeting T and natural killer cells to inhibit tumour growth 1 , 2 . Here, using high-throughput flow cytometry as well as bulk and single-cell RNA-sequencing and B-cell-receptor-sequencing analysis of B cells temporally during B16F10 melanoma growth, we identified a subset of B cells that expands specifically in the draining lymph node over time in tumour-bearing mice. The expanding B cell subset expresses the cell surface molecule T cell immunoglobulin and mucin domain 1 (TIM-1, encoded by Havcr1 ) and a unique transcriptional signature, including multiple co-inhibitory molecules such as PD-1, TIM-3, TIGIT and LAG-3. Although conditional deletion of these co-inhibitory molecules on B cells had little or no effect on tumour burden, selective deletion of Havcr1 in B cells both substantially inhibited tumour growth and enhanced effector T cell responses. Loss of TIM-1 enhanced the type 1 interferon response in B cells, which augmented B cell activation and increased antigen presentation and co-stimulation, resulting in increased expansion of tumour-specific effector T cells. Our results demonstrate that manipulation of TIM-1-expressing B cells enables engagement of the second arm of adaptive immunity to promote anti-tumour immunity and inhibit tumour growth. Manipulation of TIM-1-expressing B cells enables engagement of the second arm of adaptive immunity to promote anti-tumour immunity and inhibit tumour growth. |
| Author | Shi, Jingwen Li, Zhaorong Schnell, Alexandra Barilla, Rocky M. Apetoh, Lionel Torlai Triglia, Elena Sharpe, Arlene H. Giuliano, Christopher J. Xiao, Sheng Kuchroo, Vijay K. Fisher, David E. Zaghouani, Sarah Kuchroo, Juhi R. Kye, Yoon-Chul Quintana, Francisco J. Rothstein, David M. Slingerland, Nadine Ashenberg, Orr Regev, Aviv Mohib, Kanishka Bod, Lloyd Delorey, Toni Marie Rozenblatt-Rosen, Orit Ostrowski, Stephen M. Fessler, Johannes Von-Franque, Max Y. Christian, Elena |
| AuthorAffiliation | 5 Current address: Division of Immunology and Pathophysiology, Medical University of Graz, 8036 Graz, Austria 13 Currrent address: Genentech, 1 DNA Way, South San Francisco, CA 94025, USA 2 Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA 14 Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA 1 Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women’s Hospital, Boston, MA, USA 10 INSERM, U1100, Tours, France 3 Current address: Massachusetts General Hospital Cancer Center, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA 6 Department of Dermatology, Massachusetts General Hospital, Boston, Massachusetts 7 Thomas E. Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261 12 Howard Hughes Medical Institute, Department of Biology and Koch Institute of Integrative Cancer Research, Massac |
| AuthorAffiliation_xml | – name: 7 Thomas E. Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261 – name: 13 Currrent address: Genentech, 1 DNA Way, South San Francisco, CA 94025, USA – name: 2 Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA – name: 10 INSERM, U1100, Tours, France – name: 14 Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA – name: 1 Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women’s Hospital, Boston, MA, USA – name: 9 Current address: HiFiBio Therapeutics, Cambridge, MA 02139, USA – name: 5 Current address: Division of Immunology and Pathophysiology, Medical University of Graz, 8036 Graz, Austria – name: 8 Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA, USA – name: 4 Current address: BeiGene Co., Ltd., Beijing, China – name: 11 Faculté de Médecine, Université de Tours, Tours, France – name: 3 Current address: Massachusetts General Hospital Cancer Center, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA – name: 12 Howard Hughes Medical Institute, Department of Biology and Koch Institute of Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA – name: 6 Department of Dermatology, Massachusetts General Hospital, Boston, Massachusetts |
| Author_xml | – sequence: 1 givenname: Lloyd surname: Bod fullname: Bod, Lloyd organization: Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women’s Hospital, Klarman Cell Observatory, Broad Institute of MIT and Harvard, Gene Lay Institute of Immunology and Inflammation, Brigham and Women’s Hospital, Massachusetts General Hospital and Harvard Medical School, Massachusetts General Hospital Cancer Center, Department of Medicine, Massachusetts General Hospital, Harvard Medical School – sequence: 2 givenname: Yoon-Chul orcidid: 0000-0003-0261-5247 surname: Kye fullname: Kye, Yoon-Chul organization: Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women’s Hospital, Klarman Cell Observatory, Broad Institute of MIT and Harvard, Gene Lay Institute of Immunology and Inflammation, Brigham and Women’s Hospital, Massachusetts General Hospital and Harvard Medical School – sequence: 3 givenname: Jingwen surname: Shi fullname: Shi, Jingwen organization: Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women’s Hospital, Klarman Cell Observatory, Broad Institute of MIT and Harvard, BeiGene – sequence: 4 givenname: Elena orcidid: 0000-0002-6059-0116 surname: Torlai Triglia fullname: Torlai Triglia, Elena organization: Klarman Cell Observatory, Broad Institute of MIT and Harvard – sequence: 5 givenname: Alexandra orcidid: 0000-0003-3442-7750 surname: Schnell fullname: Schnell, Alexandra organization: Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women’s Hospital, Klarman Cell Observatory, Broad Institute of MIT and Harvard, Gene Lay Institute of Immunology and Inflammation, Brigham and Women’s Hospital, Massachusetts General Hospital and Harvard Medical School – sequence: 6 givenname: Johannes surname: Fessler fullname: Fessler, Johannes organization: Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women’s Hospital, Division of Immunology and Pathophysiology, Medical University of Graz – sequence: 7 givenname: Stephen M. surname: Ostrowski fullname: Ostrowski, Stephen M. organization: Department of Dermatology, Massachusetts General Hospital – sequence: 8 givenname: Max Y. orcidid: 0000-0002-5232-6454 surname: Von-Franque fullname: Von-Franque, Max Y. organization: Department of Dermatology, Massachusetts General Hospital – sequence: 9 givenname: Juhi R. surname: Kuchroo fullname: Kuchroo, Juhi R. organization: Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women’s Hospital, Department of Microbiology and Immunobiology, Harvard Medical School – sequence: 10 givenname: Rocky M. orcidid: 0000-0002-8062-7246 surname: Barilla fullname: Barilla, Rocky M. organization: Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women’s Hospital, Gene Lay Institute of Immunology and Inflammation, Brigham and Women’s Hospital, Massachusetts General Hospital and Harvard Medical School – sequence: 11 givenname: Sarah orcidid: 0000-0002-4467-6542 surname: Zaghouani fullname: Zaghouani, Sarah organization: Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women’s Hospital – sequence: 12 givenname: Elena surname: Christian fullname: Christian, Elena organization: Klarman Cell Observatory, Broad Institute of MIT and Harvard – sequence: 13 givenname: Toni Marie orcidid: 0000-0001-6614-3803 surname: Delorey fullname: Delorey, Toni Marie organization: Klarman Cell Observatory, Broad Institute of MIT and Harvard – sequence: 14 givenname: Kanishka orcidid: 0000-0002-7332-5530 surname: Mohib fullname: Mohib, Kanishka organization: Thomas E. Starzl Transplantation Institute, University of Pittsburgh School of Medicine – sequence: 15 givenname: Sheng surname: Xiao fullname: Xiao, Sheng organization: Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women’s Hospital – sequence: 16 givenname: Nadine orcidid: 0000-0002-3134-6472 surname: Slingerland fullname: Slingerland, Nadine organization: Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women’s Hospital, Klarman Cell Observatory, Broad Institute of MIT and Harvard – sequence: 17 givenname: Christopher J. orcidid: 0000-0002-0586-6095 surname: Giuliano fullname: Giuliano, Christopher J. organization: Klarman Cell Observatory, Broad Institute of MIT and Harvard – sequence: 18 givenname: Orr surname: Ashenberg fullname: Ashenberg, Orr organization: Klarman Cell Observatory, Broad Institute of MIT and Harvard – sequence: 19 givenname: Zhaorong orcidid: 0000-0002-5268-6986 surname: Li fullname: Li, Zhaorong organization: Ann Romney Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School – sequence: 20 givenname: David M. orcidid: 0000-0002-9455-7971 surname: Rothstein fullname: Rothstein, David M. organization: Thomas E. Starzl Transplantation Institute, University of Pittsburgh School of Medicine – sequence: 21 givenname: David E. surname: Fisher fullname: Fisher, David E. organization: Department of Dermatology, Massachusetts General Hospital – sequence: 22 givenname: Orit orcidid: 0000-0001-6313-3570 surname: Rozenblatt-Rosen fullname: Rozenblatt-Rosen, Orit organization: Klarman Cell Observatory, Broad Institute of MIT and Harvard, Howard Hughes Medical Institute, Department of Biology and Koch Institute of Integrative Cancer Research, Massachusetts Institute of Technology – sequence: 23 givenname: Arlene H. orcidid: 0000-0002-9736-2109 surname: Sharpe fullname: Sharpe, Arlene H. organization: Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women’s Hospital, Department of Microbiology and Immunobiology, Harvard Medical School – sequence: 24 givenname: Francisco J. orcidid: 0000-0001-8156-0736 surname: Quintana fullname: Quintana, Francisco J. organization: Klarman Cell Observatory, Broad Institute of MIT and Harvard, Howard Hughes Medical Institute, Department of Biology and Koch Institute of Integrative Cancer Research, Massachusetts Institute of Technology – sequence: 25 givenname: Lionel orcidid: 0000-0002-2774-438X surname: Apetoh fullname: Apetoh, Lionel organization: Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women’s Hospital, INSERM, Faculté de Médecine, Université de Tours – sequence: 26 givenname: Aviv orcidid: 0000-0003-3293-3158 surname: Regev fullname: Regev, Aviv email: aviv.regev.sc@gmail.com organization: Klarman Cell Observatory, Broad Institute of MIT and Harvard, Howard Hughes Medical Institute, Department of Biology and Koch Institute of Integrative Cancer Research, Massachusetts Institute of Technology, Genentech – sequence: 27 givenname: Vijay K. orcidid: 0000-0001-7177-2110 surname: Kuchroo fullname: Kuchroo, Vijay K. email: vkuchroo@rics.bwh.harvard.edu organization: Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women’s Hospital, Klarman Cell Observatory, Broad Institute of MIT and Harvard, Gene Lay Institute of Immunology and Inflammation, Brigham and Women’s Hospital, Massachusetts General Hospital and Harvard Medical School |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/37344597$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9kUFvFSEUhYmpsa_VP9CFmcSNG-plgAFWjTa2NWniRteEYZj3qDPwCoxJ_708X1trF12xuN853HPPEToIMTiETgicEqDyU2aEyw5DSzF0LSUYXqEVYaLDrJPiAK0AWolB0u4QHeV8AwCcCPYGHVJBGeNKrNDlF2zdNOG8ddaP3jZ24-yvbfShNHOcnF0ml5uyMaVJbr1MprjGhOJxWea4pMbP8xJ8uXuLXo9myu7d_XuMfl58_XF-ha-_X347_3yNLRO84JZ2bOzYAJz2hvbjMDDijBDEDIyOpOdSDb0RVI2Sgey5UiPjIJwcBCFKEXqMzva-26Wf3WBdKMlMepv8bNKdjsbr_yfBb_Q6_tYEhOJMyOrw8d4hxdvF5aJnn3c3MMHFJetWtlIIClxU9MMz9KZmDjVfpagUsuVUVer905Ued3k4cgXaPWBTzDm58REhoHdN6n2Tujap_zapoYrkM5H1xRQfd7H89LKU7qW5_hPWLv1b-wXVHxhhsng |
| CitedBy_id | crossref_primary_10_1681_ASN_0000000000000334 crossref_primary_10_1038_s41590_024_01990_y crossref_primary_10_1038_s42003_025_07800_x crossref_primary_10_1161_CIRCRESAHA_124_324243 crossref_primary_10_1093_lifemedi_lnae015 crossref_primary_10_1186_s13045_024_01613_x crossref_primary_10_1097_MD_0000000000040432 crossref_primary_10_1136_jitc_2024_011427 crossref_primary_10_1038_s41423_025_01334_2 crossref_primary_10_3389_fimmu_2025_1537947 crossref_primary_10_1146_annurev_cancerbio_060624_045703 crossref_primary_10_1111_imr_70059 crossref_primary_10_3389_fimmu_2025_1674174 crossref_primary_10_1182_bloodadvances_2023011463 crossref_primary_10_1016_j_coi_2024_102504 crossref_primary_10_3389_fimmu_2024_1500228 crossref_primary_10_1016_j_bioactmat_2024_05_014 crossref_primary_10_3389_fimmu_2024_1464480 crossref_primary_10_1016_j_ccell_2024_09_011 crossref_primary_10_1016_j_coi_2024_102431 crossref_primary_10_1007_s12672_025_01747_5 crossref_primary_10_1007_s00262_025_04168_z crossref_primary_10_1016_j_jconrel_2025_114118 crossref_primary_10_7554_eLife_97335 crossref_primary_10_1016_j_intimp_2024_113037 crossref_primary_10_1007_s00403_025_03802_1 crossref_primary_10_3389_fimmu_2024_1407403 crossref_primary_10_1002_adma_202400756 crossref_primary_10_1200_JCO_24_01818 crossref_primary_10_1186_s13045_024_01634_6 crossref_primary_10_1007_s12672_025_03458_3 crossref_primary_10_1007_s40257_024_00907_7 crossref_primary_10_3389_fimmu_2024_1336493 crossref_primary_10_1016_j_cmet_2023_12_020 crossref_primary_10_1038_s41586_024_08033_4 crossref_primary_10_1016_j_tranon_2024_101885 crossref_primary_10_3390_cancers15205108 crossref_primary_10_1007_s12032_025_02739_9 crossref_primary_10_1038_s41591_025_03873_7 crossref_primary_10_1007_s00262_024_03936_7 crossref_primary_10_1016_j_jconrel_2025_114070 crossref_primary_10_1093_oxfimm_iqae012 crossref_primary_10_7717_peerj_17184 crossref_primary_10_1016_j_jconrel_2024_02_029 crossref_primary_10_1016_j_immuni_2024_01_010 crossref_primary_10_1016_j_jddst_2024_106376 crossref_primary_10_1093_jleuko_qiad138 crossref_primary_10_3389_fmicb_2025_1547964 crossref_primary_10_1007_s11684_025_1127_5 crossref_primary_10_3748_wjg_v30_i34_3894 crossref_primary_10_1016_j_jaccao_2025_06_008 crossref_primary_10_1016_j_heliyon_2024_e39496 crossref_primary_10_31083_j_fbl2909315 crossref_primary_10_1038_s41698_024_00627_5 crossref_primary_10_1038_s41568_024_00761_z crossref_primary_10_1038_s41392_023_01643_w crossref_primary_10_1002_adfm_202416147 crossref_primary_10_2147_JIR_S478568 crossref_primary_10_1136_jitc_2024_009893 crossref_primary_10_3389_fimmu_2025_1499663 crossref_primary_10_1038_s41467_024_52324_3 crossref_primary_10_2147_ITT_S493217 crossref_primary_10_3389_fimmu_2024_1490712 crossref_primary_10_3390_cells14050346 crossref_primary_10_1002_mog2_92 crossref_primary_10_1016_j_crphys_2025_100152 crossref_primary_10_1021_acsnano_4c15113 crossref_primary_10_1016_j_jtho_2024_12_026 crossref_primary_10_1371_journal_ppat_1011982 crossref_primary_10_1016_j_canlet_2024_216951 crossref_primary_10_7554_eLife_97335_3 crossref_primary_10_1038_s41523_025_00721_2 crossref_primary_10_1002_mef2_71 crossref_primary_10_1080_25785826_2025_2454045 crossref_primary_10_1016_j_bbcan_2025_189298 crossref_primary_10_1016_j_tranon_2024_101952 crossref_primary_10_3389_fonc_2025_1636942 crossref_primary_10_1016_j_mucimm_2024_09_003 crossref_primary_10_1002_mco2_70274 crossref_primary_10_1038_s41423_024_01211_4 crossref_primary_10_1016_j_jid_2025_07_027 crossref_primary_10_1038_s42003_024_06568_w crossref_primary_10_3389_fimmu_2025_1602868 crossref_primary_10_3390_ijms252011256 crossref_primary_10_1002_mog2_70030 crossref_primary_10_3389_fimmu_2024_1375486 crossref_primary_10_15212_bioi_2025_0041 crossref_primary_10_1038_s41598_024_59337_4 crossref_primary_10_1002_advs_202403423 crossref_primary_10_1038_s41586_024_08247_6 crossref_primary_10_1136_jitc_2023_008636 crossref_primary_10_1136_jitc_2024_009861 crossref_primary_10_3389_fimmu_2025_1578470 crossref_primary_10_1097_TP_0000000000004948 crossref_primary_10_1172_JCI174249 crossref_primary_10_1016_j_xcrm_2025_102210 crossref_primary_10_1177_00220345241307894 |
| Cites_doi | 10.1126/science.1213368 10.4049/jimmunol.182.3.1379 10.1007/s00262-011-1071-x 10.1007/s00262-018-2282-1 10.1038/nbt.3192 10.15252/msb.20199005 10.4161/23723556.2014.977150 10.1038/s41588-021-00911-1 10.1038/s41467-021-21413-y 10.1016/j.oraloncology.2015.11.003 10.1016/j.cell.2021.08.003 10.1016/j.cell.2018.10.038 10.1101/791699 10.1038/s41586-018-0206-z 10.1038/s41586-019-1914-8 10.1158/2326-6066.CIR-17-0075 10.1093/nar/gkz430 10.1016/j.celrep.2020.107892 10.1038/s41467-018-04647-1 10.1038/ni1185 10.1038/s41591-021-01323-8 10.1084/jem.20062498 10.1016/j.cell.2020.03.048 10.1038/s41592-020-0905-x 10.1038/s41467-019-12160-2 10.1016/j.ccell.2021.02.015 10.4049/jimmunol.1402632 10.1101/gr.240390.118 10.1038/nprot.2014.006 10.1186/1471-2105-12-323 10.1016/j.celrep.2018.06.046 10.1073/pnas.1120914109 10.1172/JCI46274 10.1038/s41577-019-0224-6 10.1111/ajt.13087 10.1172/JCI59266 10.1016/j.cell.2018.09.006 10.1016/j.immuni.2018.06.007 10.1016/j.cell.2014.07.027 10.1002/eji.201040993 10.1056/NEJMoa1302369 10.1126/science.aal5081 10.1038/s41586-019-1922-8 10.4049/jimmunol.1602107 10.1038/s41577-019-0257-x 10.1093/intimm/13.12.1583 10.1126/science.aad0501 10.1038/s41592-019-0619-0 10.1172/jci.insight.139032 10.1038/s41587-021-01033-z 10.1371/journal.pone.0199034 10.1016/j.ccell.2022.02.013 10.1016/S1074-7613(01)00126-1 10.1093/intimm/14.4.411 10.1016/j.immuni.2018.03.023 10.1158/1078-0432.CCR-10-1114 10.1056/NEJMoa1200690 10.1038/s41422-020-0355-0 10.1016/j.cell.2020.02.015 10.1093/nar/gky379 10.1093/bioinformatics/btv359 10.1016/j.cels.2018.11.005 10.1038/s41591-019-0522-3 10.1016/j.ccr.2009.12.019 10.3389/fimmu.2021.749190 10.3389/fimmu.2015.00067 10.1073/pnas.0508643102 10.1007/978-1-0716-1237-8_10 10.1016/j.smim.2019.101323 10.1038/s41591-019-0654-5 |
| ContentType | Journal Article |
| Copyright | The Author(s), under exclusive licence to Springer Nature Limited 2023 corrected publication 2025 Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. 2023. The Author(s), under exclusive licence to Springer Nature Limited. Copyright Nature Publishing Group Jul 13, 2023 |
| Copyright_xml | – notice: The Author(s), under exclusive licence to Springer Nature Limited 2023 corrected publication 2025 Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. – notice: 2023. The Author(s), under exclusive licence to Springer Nature Limited. – notice: Copyright Nature Publishing Group Jul 13, 2023 |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 3V. 7QG 7QL 7QP 7QR 7RV 7SN 7SS 7ST 7T5 7TG 7TK 7TM 7TO 7U9 7X2 7X7 7XB 88A 88E 88G 88I 8AF 8AO 8C1 8FD 8FE 8FG 8FH 8FI 8FJ 8FK 8G5 ABJCF ABUWG AEUYN AFKRA ARAPS ATCPS AZQEC BBNVY BEC BENPR BGLVJ BHPHI BKSAR C1K CCPQU D1I DWQXO FR3 FYUFA GHDGH GNUQQ GUQSH H94 HCIFZ K9. KB. KB0 KL. L6V LK8 M0K M0S M1P M2M M2O M2P M7N M7P M7S MBDVC NAPCQ P5Z P62 P64 PATMY PCBAR PDBOC PHGZM PHGZT PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS PSYQQ PTHSS PYCSY Q9U R05 RC3 S0X SOI 7X8 5PM |
| DOI | 10.1038/s41586-023-06231-0 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Animal Behavior Abstracts Bacteriology Abstracts (Microbiology B) Calcium & Calcified Tissue Abstracts Chemoreception Abstracts Nursing & Allied Health Database Ecology Abstracts Entomology Abstracts (Full archive) Environment Abstracts Immunology Abstracts Meteorological & Geoastrophysical Abstracts Neurosciences Abstracts Nucleic Acids Abstracts Oncogenes and Growth Factors Abstracts Virology and AIDS Abstracts Agricultural Science Collection Health & Medical Collection ProQuest Central (purchase pre-March 2016) Biology Database (Alumni Edition) Medical Database (Alumni Edition) Psychology Database (Alumni) Science Database (Alumni Edition) STEM Database ProQuest Pharma Collection Public Health Database Technology Research Database ProQuest SciTech Collection ProQuest Technology Collection ProQuest Natural Science Journals ProQuest Hospital Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) Research Library ProQuest Materials Science & Engineering Collection ProQuest Central (Alumni) ProQuest One Sustainability ProQuest Central UK/Ireland Advanced Technologies & Computer Science Collection ProQuest Agricultural & Environmental Science Collection ProQuest Central Essentials Local Electronic Collection Information Biological Science Collection eLibrary Curriculum ProQuest Central Technology Collection Natural Science Collection ProQuest Earth, Atmospheric & Aquatic Science Collection Environmental Sciences and Pollution Management ProQuest One Community College ProQuest Materials Science Collection ProQuest Central Engineering Research Database Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student Research Library Prep AIDS and Cancer Research Abstracts SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Materials Science Database Nursing & Allied Health Database (Alumni Edition) Meteorological & Geoastrophysical Abstracts - Academic ProQuest Engineering Collection Biological Sciences Agricultural Science Database ProQuest Health & Medical Collection PML(ProQuest Medical Library) Psychology Database Research Library Science Database Algology Mycology and Protozoology Abstracts (Microbiology C) Biological Science Database Engineering Database Research Library (Corporate) Nursing & Allied Health Premium Advanced Technologies & Aerospace Database ProQuest Advanced Technologies & Aerospace Collection Biotechnology and BioEngineering Abstracts Environmental Science Database Earth, Atmospheric & Aquatic Science Database Materials Science Collection ProQuest Central Premium ProQuest One Academic ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China ProQuest One Psychology Engineering Collection Environmental Science Collection ProQuest Central Basic University of Michigan Genetics Abstracts SIRS Editorial Environment Abstracts MEDLINE - Academic PubMed Central (Full Participant titles) |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Agricultural Science Database ProQuest One Psychology Research Library Prep ProQuest Central Student Oncogenes and Growth Factors Abstracts ProQuest Advanced Technologies & Aerospace Collection ProQuest Central Essentials Nucleic Acids Abstracts elibrary ProQuest AP Science SciTech Premium Collection ProQuest Central China Environmental Sciences and Pollution Management ProQuest One Applied & Life Sciences ProQuest One Sustainability Health Research Premium Collection Meteorological & Geoastrophysical Abstracts Natural Science Collection Health & Medical Research Collection Biological Science Collection Chemoreception Abstracts ProQuest Central (New) ProQuest Medical Library (Alumni) Engineering Collection Advanced Technologies & Aerospace Collection Engineering Database Virology and AIDS Abstracts ProQuest Science Journals (Alumni Edition) ProQuest Biological Science Collection ProQuest One Academic Eastern Edition Earth, Atmospheric & Aquatic Science Database Agricultural Science Collection ProQuest Hospital Collection ProQuest Technology Collection Health Research Premium Collection (Alumni) Biological Science Database Ecology Abstracts Neurosciences Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts Environmental Science Collection Entomology Abstracts Nursing & Allied Health Premium ProQuest Health & Medical Complete ProQuest One Academic UKI Edition Environmental Science Database ProQuest Nursing & Allied Health Source (Alumni) Engineering Research Database ProQuest One Academic Calcium & Calcified Tissue Abstracts Meteorological & Geoastrophysical Abstracts - Academic ProQuest One Academic (New) University of Michigan Technology Collection Technology Research Database ProQuest One Academic Middle East (New) SIRS Editorial Materials Science Collection ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing Research Library (Alumni Edition) ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Biology Journals (Alumni Edition) ProQuest Central Earth, Atmospheric & Aquatic Science Collection ProQuest Health & Medical Research Collection Genetics Abstracts ProQuest Engineering Collection Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Bacteriology Abstracts (Microbiology B) Algology Mycology and Protozoology Abstracts (Microbiology C) Agricultural & Environmental Science Collection AIDS and Cancer Research Abstracts Materials Science Database ProQuest Research Library ProQuest Materials Science Collection ProQuest Public Health ProQuest Central Basic ProQuest Science Journals ProQuest Nursing & Allied Health Source ProQuest Psychology Journals (Alumni) ProQuest SciTech Collection Advanced Technologies & Aerospace Database ProQuest Medical Library ProQuest Psychology Journals Animal Behavior Abstracts Materials Science & Engineering Collection Immunology Abstracts Environment Abstracts ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | Agricultural Science Database MEDLINE MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: PATMY name: Environmental Science Database url: http://search.proquest.com/environmentalscience sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Sciences (General) Physics |
| EISSN | 1476-4687 |
| EndPage | 356 |
| ExternalDocumentID | PMC10795478 37344597 10_1038_s41586_023_06231_0 |
| Genre | Research Support, Non-U.S. Gov't Journal Article Research Support, N.I.H., Extramural |
| GrantInformation_xml | – fundername: NIAID NIH HHS grantid: P01 AI056299 – fundername: NIAID NIH HHS grantid: P01 AI039671 – fundername: NIAID NIH HHS grantid: P01 AI129880 – fundername: NIAID NIH HHS grantid: P01 AI073748 – fundername: NIAID NIH HHS grantid: R01 AI144166 |
| GroupedDBID | --- --Z -DZ -ET -~X .55 .CO .XZ 07C 0R~ 0WA 123 186 1OL 1VR 29M 2KS 2XV 39C 41X 53G 5RE 6TJ 70F 7RV 7X2 7X7 7XC 85S 88E 88I 8AF 8AO 8C1 8CJ 8FE 8FG 8FH 8FI 8FJ 8G5 8R4 8R5 8WZ 97F 97L A6W A7Z AAHBH AAHTB AAIKC AAKAB AAMNW AASDW AAYEP AAYZH ABDQB ABFSI ABIVO ABJCF ABJNI ABLJU ABOCM ABPEJ ABPPZ ABUWG ABWJO ABZEH ACBEA ACBWK ACGFO ACGFS ACGOD ACIWK ACKOT ACMFV ACMJI ACNCT ACPRK ACWUS ADBBV ADFRT ADUKH AENEX AEUYN AFANA AFBBN AFFNX AFKRA AFLOW AFRAH AFSHS AGAYW AGHSJ AGOIJ AGSOS AHMBA AHSBF AIDUJ ALFFA ALIPV ALMA_UNASSIGNED_HOLDINGS ALPWD AMTXH ARAPS ARMCB ASPBG ATCPS ATHPR ATWCN AVWKF AXYYD AZFZN AZQEC BBNVY BCU BEC BENPR BGLVJ BHPHI BIN BKEYQ BKKNO BKSAR BPHCQ BVXVI CCPQU CJ0 CS3 D1I D1J D1K DU5 DWQXO E.- E.L EAP EBS EE. EMH EPS EX3 EXGXG F5P FAC FEDTE FQGFK FSGXE FYUFA GNUQQ GUQSH HCIFZ HG6 HMCUK HVGLF HZ~ IAO ICQ IEA IEP IGS IH2 IHR INH INR IOF IPY ISR K6- KB. KOO L6V L7B LGEZI LK5 LK8 LOTEE LSO M0K M1P M2M M2O M2P M7P M7R M7S N9A NADUK NAPCQ NEPJS NFIDA NXXTH O9- OBC OES OHH OMK OVD P2P P62 PATMY PCBAR PDBOC PHGZM PHGZT PQQKQ PROAC PSQYO PSYQQ PTHSS PYCSY Q2X R05 RND RNS RNT RNTTT RXW S0X SC5 SHXYY SIXXV SJFOW SJN SNYQT SOJ TAE TAOOD TBHMF TDRGL TEORI TN5 TSG TWZ U5U UKHRP UKR UMC UMD UQL VVN WH7 WOW X7M XIH XKW XZL Y6R YAE YFH YJ6 YNT YOC YQT YR2 YR5 YXB YZZ ZCA ~02 ~7V ~88 ~KM AARCD AAYXX ABFSG ABUFD ACSTC AEZWR AFFHD AFHIU AFKWF AGSTI AHWEU AIXLP CITATION PJZUB PPXIY PQGLB TUS .-4 .GJ .HR 00M 08P 1CY 1VW 354 3EH 3O- 4.4 41~ 42X 4R4 663 79B 9M8 A8Z AAJYS AAKAS AAVBQ ABAWZ ABDBF ABDPE ABEFU ABNNU ACBNA ACBTR ACRPL ACTDY ACUHS ADGHP ADNMO ADRHT ADXHL ADYSU ADZCM AETEA AFFDN AFHKK AGCDD AGGDT AGNAY AGQPQ AIDAL AIYXT AJUXI APEBS ARTTT B0M BCR BDKGC BES BKOMP BLC CGR CUY CVF DB5 DO4 EAD EAS EAZ EBC EBD EBO ECC ECM EIF EJD EMB EMF EMK EMOBN EPL ESE ESN ESTFP ESX FA8 I-F ITC J5H L-9 MVM N4W NEJ NPM ODYON OHT P-O PEA PM3 PUEGO PV9 QS- R4F RHI SKT SV3 TH9 TUD UBY UHB USG VOH X7L XOL YQI YQJ YV5 YXA YYP YYQ ZCG ZE2 ZGI ZHY ZKB ZY4 ~8M ~G0 3V. 7QG 7QL 7QP 7QR 7SN 7SS 7ST 7T5 7TG 7TK 7TM 7TO 7U9 7XB 88A 8FD 8FK C1K FR3 H94 K9. KL. M7N MBDVC P64 PKEHL PQEST PQUKI PRINS Q9U RC3 SOI 7X8 5PM |
| ID | FETCH-LOGICAL-c475t-2364f64d053ba3bfdd41ea771ad43f1b589dba739f8408b599f4507e8d7119913 |
| IEDL.DBID | M7P |
| ISICitedReferencesCount | 107 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=001019174100008&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 0028-0836 1476-4687 |
| IngestDate | Tue Nov 04 02:06:00 EST 2025 Sun Nov 09 10:53:47 EST 2025 Tue Oct 07 07:15:41 EDT 2025 Wed Sep 24 03:02:43 EDT 2025 Tue Nov 18 22:25:18 EST 2025 Sat Nov 29 08:11:47 EST 2025 Thu May 22 04:29:40 EDT 2025 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 7969 |
| Language | English |
| License | 2023. The Author(s), under exclusive licence to Springer Nature Limited. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c475t-2364f64d053ba3bfdd41ea771ad43f1b589dba739f8408b599f4507e8d7119913 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Author’s contribution LB and VKK conceived the study. LB with assistance from YCK, JS, AS, SMO, MYVF, DEF, JF, RMB, SZ, SX, designed, performed and analyzed the biological experiments. LB with assistance from YCK, JS, AS, EC, TMD, performed the sequencing experiments, with guidance from AR and ORR. LB, NS,CJG,ZL, FJQ, OA and ETT designed and performed the computational analysis, with guidance from AR. LB, JS, ETT, LA, VKK and AR interpreted the results. JRK and AH S generated and provided the PD-1fl/fl mice. KM and DMR generated and performed the experiments using the CD19Cre/+ x IL-10fl/fl mice. The manuscript was written by LB with assistance from ETT and was edited by LA, AR, and VKK with input from all authors. |
| ORCID | 0000-0002-9455-7971 0000-0001-7177-2110 0000-0002-9736-2109 0000-0002-3134-6472 0000-0002-5232-6454 0000-0001-6614-3803 0000-0002-7332-5530 0000-0001-8156-0736 0000-0001-6313-3570 0000-0003-3442-7750 0000-0002-8062-7246 0000-0002-2774-438X 0000-0002-6059-0116 0000-0003-0261-5247 0000-0002-4467-6542 0000-0002-0586-6095 0000-0002-5268-6986 0000-0003-3293-3158 |
| OpenAccessLink | https://pmc.ncbi.nlm.nih.gov/articles/PMC10795478/pdf/nihms-1956582.pdf |
| PMID | 37344597 |
| PQID | 2838782539 |
| PQPubID | 40569 |
| PageCount | 9 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_10795478 proquest_miscellaneous_2828773057 proquest_journals_2838782539 pubmed_primary_37344597 crossref_primary_10_1038_s41586_023_06231_0 crossref_citationtrail_10_1038_s41586_023_06231_0 springer_journals_10_1038_s41586_023_06231_0 |
| PublicationCentury | 2000 |
| PublicationDate | 2023-07-13 |
| PublicationDateYYYYMMDD | 2023-07-13 |
| PublicationDate_xml | – month: 07 year: 2023 text: 2023-07-13 day: 13 |
| PublicationDecade | 2020 |
| PublicationPlace | London |
| PublicationPlace_xml | – name: London – name: England |
| PublicationSubtitle | International weekly journal of science |
| PublicationTitle | Nature (London) |
| PublicationTitleAbbrev | Nature |
| PublicationTitleAlternate | Nature |
| PublicationYear | 2023 |
| Publisher | Nature Publishing Group UK Nature Publishing Group |
| Publisher_xml | – name: Nature Publishing Group UK – name: Nature Publishing Group |
| References | J Griss (6231_CR4) 2019; 10 A Rivera (6231_CR48) 2001; 13 JD Wolchok (6231_CR2) 2013; 369 A Bassez (6231_CR23) 2021; 27 JH Meyers (6231_CR44) 2005; 6 PP Domeier (6231_CR32) 2018; 24 I Tirosh (6231_CR14) 2016; 352 S Xiao (6231_CR41) 2011; 41 C Mariat (6231_CR42) 2009; 182 TC Bruno (6231_CR47) 2017; 5 J Qian (6231_CR18) 2020; 30 L Zhang (6231_CR21) 2020; 181 SL Wolock (6231_CR58) 2019; 8 SL Topalian (6231_CR1) 2012; 366 Q Ding (6231_CR38) 2017; 199 K Pelka (6231_CR19) 2021; 184 I Korsunsky (6231_CR59) 2019; 16 NT Gupta (6231_CR6) 2015; 31 MY Yeung (6231_CR13) 2015; 15 Q Ding (6231_CR12) 2011; 121 A Le Bon (6231_CR33) 2001; 14 C Cerqueira (6231_CR25) 2019; 44 N Chihara (6231_CR55) 2018; 558 S Xiao (6231_CR10) 2015; 194 AJ de Souza (6231_CR40) 2005; 102 B Li (6231_CR56) 2020; 17 D Liu (6231_CR62) 2019; 25 6231_CR39 Y Lu (6231_CR36) 2020; 180 E Hilgenberg (6231_CR31) 2014; 380 A Ladanyi (6231_CR5) 2011; 60 SZ Wu (6231_CR16) 2021; 53 R Satija (6231_CR65) 2015; 33 V Thorsson (6231_CR3) 2018; 48 C Germain (6231_CR50) 2015; 6 CJ Ye (6231_CR69) 2018; 28 B Li (6231_CR67) 2011; 12 RAM Rossetti (6231_CR49) 2018; 13 E Dann (6231_CR70) 2022; 40 KM Mahoney (6231_CR68) 2019; 68 AM Khalil (6231_CR53) 2012; 336 M Sade-Feldman (6231_CR20) 2018; 175 L Jerby-Arnon (6231_CR24) 2018; 175 6231_CR26 K Bi (6231_CR17) 2021; 39 B Zhou (6231_CR37) 2021; 12 Y Wolf (6231_CR8) 2020; 20 C Delaney (6231_CR7) 2019; 15 S Xiao (6231_CR29) 2020; 32 L Jerby-Arnon (6231_CR61) 2014; 158 E Afgan (6231_CR66) 2018; 46 GV Sharonov (6231_CR45) 2020; 20 Y Liu (6231_CR15) 2022; 40 S Picelli (6231_CR64) 2014; 9 S Xiao (6231_CR11) 2012; 109 P Andreu (6231_CR35) 2010; 17 S Hervas-Stubbs (6231_CR34) 2011; 17 AC Lino (6231_CR28) 2018; 49 JS Lee (6231_CR63) 2018; 9 S Xiao (6231_CR43) 2007; 204 R Cabrita (6231_CR51) 2020; 577 BA Helmink (6231_CR52) 2020; 577 KE Yost (6231_CR22) 2019; 25 6231_CR57 6231_CR54 L Jerby-Arnon (6231_CR60) 2015; 2 M Horikawa (6231_CR30) 2011; 121 K Mohib (6231_CR9) 2021; 2270 Z Tang (6231_CR71) 2019; 47 MM Hasan (6231_CR27) 2021; 12 D Braun (6231_CR46) 2002; 14 37857611 - Signal Transduct Target Ther. 2023 Oct 20;8(1):389. doi: 10.1038/s41392-023-01643-w. 40097822 - Nature. 2025 Apr;640(8057):E1. doi: 10.1038/s41586-025-08858-7. |
| References_xml | – volume: 336 start-page: 1178 year: 2012 ident: 6231_CR53 publication-title: Science doi: 10.1126/science.1213368 – volume: 182 start-page: 1379 year: 2009 ident: 6231_CR42 publication-title: J. Immunol. doi: 10.4049/jimmunol.182.3.1379 – volume: 60 start-page: 1729 year: 2011 ident: 6231_CR5 publication-title: Cancer Immunol. Immunother. doi: 10.1007/s00262-011-1071-x – volume: 68 start-page: 421 year: 2019 ident: 6231_CR68 publication-title: Cancer Immunol. Immunother. doi: 10.1007/s00262-018-2282-1 – volume: 33 start-page: 495 year: 2015 ident: 6231_CR65 publication-title: Nat. Biotechnol. doi: 10.1038/nbt.3192 – volume: 15 start-page: e9005 year: 2019 ident: 6231_CR7 publication-title: Mol. Syst. Biol. doi: 10.15252/msb.20199005 – volume: 2 start-page: e977150 year: 2015 ident: 6231_CR60 publication-title: Mol. Cell. Oncol. doi: 10.4161/23723556.2014.977150 – volume: 53 start-page: 1334 year: 2021 ident: 6231_CR16 publication-title: Nat. Genet. doi: 10.1038/s41588-021-00911-1 – volume: 12 year: 2021 ident: 6231_CR27 publication-title: Nat. Commun. doi: 10.1038/s41467-021-21413-y – ident: 6231_CR39 doi: 10.1016/j.oraloncology.2015.11.003 – volume: 184 start-page: 4734 year: 2021 ident: 6231_CR19 publication-title: Cell doi: 10.1016/j.cell.2021.08.003 – volume: 175 start-page: 998 year: 2018 ident: 6231_CR20 publication-title: Cell doi: 10.1016/j.cell.2018.10.038 – ident: 6231_CR57 doi: 10.1101/791699 – volume: 558 start-page: 454 year: 2018 ident: 6231_CR55 publication-title: Nature doi: 10.1038/s41586-018-0206-z – volume: 577 start-page: 561 year: 2020 ident: 6231_CR51 publication-title: Nature doi: 10.1038/s41586-019-1914-8 – volume: 5 start-page: 898 year: 2017 ident: 6231_CR47 publication-title: Cancer Immunol. Res. doi: 10.1158/2326-6066.CIR-17-0075 – volume: 47 start-page: W556 year: 2019 ident: 6231_CR71 publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkz430 – volume: 32 start-page: 107892 year: 2020 ident: 6231_CR29 publication-title: Cell Rep. doi: 10.1016/j.celrep.2020.107892 – volume: 9 year: 2018 ident: 6231_CR63 publication-title: Nat. Commun. doi: 10.1038/s41467-018-04647-1 – volume: 6 start-page: 455 year: 2005 ident: 6231_CR44 publication-title: Nat. Immunol. doi: 10.1038/ni1185 – volume: 27 start-page: 820 year: 2021 ident: 6231_CR23 publication-title: Nat. Med. doi: 10.1038/s41591-021-01323-8 – volume: 204 start-page: 1691 year: 2007 ident: 6231_CR43 publication-title: J. Exp. Med. doi: 10.1084/jem.20062498 – volume: 181 start-page: 442 year: 2020 ident: 6231_CR21 publication-title: Cell doi: 10.1016/j.cell.2020.03.048 – volume: 17 start-page: 793 year: 2020 ident: 6231_CR56 publication-title: Nat. Methods doi: 10.1038/s41592-020-0905-x – volume: 10 year: 2019 ident: 6231_CR4 publication-title: Nat. Commun. doi: 10.1038/s41467-019-12160-2 – volume: 39 start-page: 649 year: 2021 ident: 6231_CR17 publication-title: Cancer Cell doi: 10.1016/j.ccell.2021.02.015 – volume: 194 start-page: 1602 year: 2015 ident: 6231_CR10 publication-title: J. Immunol. doi: 10.4049/jimmunol.1402632 – volume: 28 start-page: 1812 year: 2018 ident: 6231_CR69 publication-title: Genome Res. doi: 10.1101/gr.240390.118 – volume: 9 start-page: 171 year: 2014 ident: 6231_CR64 publication-title: Nat. Protoc. doi: 10.1038/nprot.2014.006 – volume: 12 start-page: 323 year: 2011 ident: 6231_CR67 publication-title: BMC Bioinformatics doi: 10.1186/1471-2105-12-323 – volume: 24 start-page: 406 year: 2018 ident: 6231_CR32 publication-title: Cell Rep. doi: 10.1016/j.celrep.2018.06.046 – volume: 109 start-page: 12105 year: 2012 ident: 6231_CR11 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.1120914109 – volume: 121 start-page: 3645 year: 2011 ident: 6231_CR12 publication-title: J. Clin. Invest. doi: 10.1172/JCI46274 – volume: 20 start-page: 173 year: 2020 ident: 6231_CR8 publication-title: Nat. Rev. Immunol. doi: 10.1038/s41577-019-0224-6 – volume: 15 start-page: 942 year: 2015 ident: 6231_CR13 publication-title: Am. J. Transplant. doi: 10.1111/ajt.13087 – volume: 121 start-page: 4268 year: 2011 ident: 6231_CR30 publication-title: J. Clin. Invest. doi: 10.1172/JCI59266 – volume: 175 start-page: 984 year: 2018 ident: 6231_CR24 publication-title: Cell doi: 10.1016/j.cell.2018.09.006 – volume: 49 start-page: 120 year: 2018 ident: 6231_CR28 publication-title: Immunity doi: 10.1016/j.immuni.2018.06.007 – volume: 158 start-page: 1199 year: 2014 ident: 6231_CR61 publication-title: Cell doi: 10.1016/j.cell.2014.07.027 – volume: 41 start-page: 1539 year: 2011 ident: 6231_CR41 publication-title: Eur. J. Immunol. doi: 10.1002/eji.201040993 – volume: 369 start-page: 122 year: 2013 ident: 6231_CR2 publication-title: N. Engl. J. Med. doi: 10.1056/NEJMoa1302369 – ident: 6231_CR54 doi: 10.1126/science.aal5081 – volume: 577 start-page: 549 year: 2020 ident: 6231_CR52 publication-title: Nature doi: 10.1038/s41586-019-1922-8 – volume: 199 start-page: 2585 year: 2017 ident: 6231_CR38 publication-title: J. Immunol. doi: 10.4049/jimmunol.1602107 – volume: 20 start-page: 294 year: 2020 ident: 6231_CR45 publication-title: Nat. Rev. Immunol. doi: 10.1038/s41577-019-0257-x – volume: 13 start-page: 1583 year: 2001 ident: 6231_CR48 publication-title: Int. Immunol. doi: 10.1093/intimm/13.12.1583 – volume: 352 start-page: 189 year: 2016 ident: 6231_CR14 publication-title: Science doi: 10.1126/science.aad0501 – volume: 16 start-page: 1289 year: 2019 ident: 6231_CR59 publication-title: Nat. Methods doi: 10.1038/s41592-019-0619-0 – volume: 380 start-page: 69 year: 2014 ident: 6231_CR31 publication-title: Curr. Top. Microbiol. Immunol. – ident: 6231_CR26 doi: 10.1172/jci.insight.139032 – volume: 40 start-page: 245 year: 2022 ident: 6231_CR70 publication-title: Nat. Biotechnol. doi: 10.1038/s41587-021-01033-z – volume: 13 start-page: e0199034 year: 2018 ident: 6231_CR49 publication-title: PLoS ONE doi: 10.1371/journal.pone.0199034 – volume: 40 start-page: 424 year: 2022 ident: 6231_CR15 publication-title: Cancer Cell doi: 10.1016/j.ccell.2022.02.013 – volume: 14 start-page: 461 year: 2001 ident: 6231_CR33 publication-title: Immunity doi: 10.1016/S1074-7613(01)00126-1 – volume: 14 start-page: 411 year: 2002 ident: 6231_CR46 publication-title: Int. Immunol. doi: 10.1093/intimm/14.4.411 – volume: 48 start-page: 812 year: 2018 ident: 6231_CR3 publication-title: Immunity doi: 10.1016/j.immuni.2018.03.023 – volume: 17 start-page: 2619 year: 2011 ident: 6231_CR34 publication-title: Clin. Cancer Res. doi: 10.1158/1078-0432.CCR-10-1114 – volume: 366 start-page: 2443 year: 2012 ident: 6231_CR1 publication-title: N. Engl. J. Med. doi: 10.1056/NEJMoa1200690 – volume: 30 start-page: 745 year: 2020 ident: 6231_CR18 publication-title: Cell Res. doi: 10.1038/s41422-020-0355-0 – volume: 180 start-page: 1081 year: 2020 ident: 6231_CR36 publication-title: Cell doi: 10.1016/j.cell.2020.02.015 – volume: 46 start-page: W537 year: 2018 ident: 6231_CR66 publication-title: Nucleic Acids Res. doi: 10.1093/nar/gky379 – volume: 31 start-page: 3356 year: 2015 ident: 6231_CR6 publication-title: Bioinformatics doi: 10.1093/bioinformatics/btv359 – volume: 8 start-page: 281 year: 2019 ident: 6231_CR58 publication-title: Cell Syst. doi: 10.1016/j.cels.2018.11.005 – volume: 25 start-page: 1251 year: 2019 ident: 6231_CR22 publication-title: Nat. Med. doi: 10.1038/s41591-019-0522-3 – volume: 17 start-page: 121 year: 2010 ident: 6231_CR35 publication-title: Cancer Cell doi: 10.1016/j.ccr.2009.12.019 – volume: 12 start-page: 749190 year: 2021 ident: 6231_CR37 publication-title: Front. Immunol. doi: 10.3389/fimmu.2021.749190 – volume: 6 start-page: 67 year: 2015 ident: 6231_CR50 publication-title: Front. Immunol. doi: 10.3389/fimmu.2015.00067 – volume: 102 start-page: 17113 year: 2005 ident: 6231_CR40 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.0508643102 – volume: 2270 start-page: 179 year: 2021 ident: 6231_CR9 publication-title: Methods Mol. Biol. doi: 10.1007/978-1-0716-1237-8_10 – volume: 44 start-page: 101323 year: 2019 ident: 6231_CR25 publication-title: Semin. Immunol. doi: 10.1016/j.smim.2019.101323 – volume: 25 start-page: 1916 year: 2019 ident: 6231_CR62 publication-title: Nat. Med. doi: 10.1038/s41591-019-0654-5 – reference: 37857611 - Signal Transduct Target Ther. 2023 Oct 20;8(1):389. doi: 10.1038/s41392-023-01643-w. – reference: 40097822 - Nature. 2025 Apr;640(8057):E1. doi: 10.1038/s41586-025-08858-7. |
| SSID | ssj0005174 |
| Score | 2.6773758 |
| Snippet | The role of B cells in anti-tumour immunity is still debated and, accordingly, immunotherapies have focused on targeting T and natural killer cells to inhibit... The role ofB cells in anti-tumour immunity is still debated and, accordingly, immunotherapies have focused on targeting T and natural killer cells to inhibit... The role of B cells in anti-tumor immunity is still debated and accordingly, immunotherapies have focused on targeting T and NK cells to inhibit tumor... |
| SourceID | pubmedcentral proquest pubmed crossref springer |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 348 |
| SubjectTerms | 13/1 13/31 45 45/91 631/114 631/250/580 631/67/1813/1634 64/60 Adaptive immunity Animals Antigen Presentation Antigens B-Lymphocytes - cytology B-Lymphocytes - immunology B-Lymphocytes - metabolism Cancer CD223 antigen Cell activation Cell surface Cells Deletion Effector cells Flow Cytometry Gene sequencing Humanities and Social Sciences Immunoglobulins Immunotherapy Interferon Type I Lymph nodes Lymph Nodes - cytology Lymph Nodes - immunology Lymphocyte Activation Lymphocytes Lymphocytes B Lymphocytes T Melanoma Melanoma - immunology Melanoma - pathology Melanoma - prevention & control Melanoma, Experimental - immunology Melanoma, Experimental - pathology Mice multidisciplinary Natural killer cells PD-1 protein Receptors, Antigen, B-Cell - genetics Science Science (multidisciplinary) Sequence analysis Single-Cell Gene Expression Analysis T-Lymphocytes - cytology T-Lymphocytes - immunology Tumor Burden Tumors |
| Title | B-cell-specific checkpoint molecules that regulate anti-tumour immunity |
| URI | https://link.springer.com/article/10.1038/s41586-023-06231-0 https://www.ncbi.nlm.nih.gov/pubmed/37344597 https://www.proquest.com/docview/2838782539 https://www.proquest.com/docview/2828773057 https://pubmed.ncbi.nlm.nih.gov/PMC10795478 |
| Volume | 619 |
| WOSCitedRecordID | wos001019174100008&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVAQT databaseName: Nature customDbUrl: eissn: 1476-4687 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: RNT dateStart: 19970101 isFulltext: true titleUrlDefault: https://www.nature.com providerName: Nature Publishing – providerCode: PRVPQU databaseName: Agricultural Science Database customDbUrl: eissn: 1476-4687 dateEnd: 20241207 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: M0K dateStart: 19880107 isFulltext: true titleUrlDefault: https://search.proquest.com/agriculturejournals providerName: ProQuest – providerCode: PRVPQU databaseName: Biological Science Database customDbUrl: eissn: 1476-4687 dateEnd: 20241207 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: M7P dateStart: 19880107 isFulltext: true titleUrlDefault: http://search.proquest.com/biologicalscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Earth, Atmospheric & Aquatic Science Database customDbUrl: eissn: 1476-4687 dateEnd: 20241207 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: PCBAR dateStart: 19880107 isFulltext: true titleUrlDefault: https://search.proquest.com/eaasdb providerName: ProQuest – providerCode: PRVPQU databaseName: Engineering Database customDbUrl: eissn: 1476-4687 dateEnd: 20241207 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: M7S dateStart: 19880107 isFulltext: true titleUrlDefault: http://search.proquest.com providerName: ProQuest – providerCode: PRVPQU databaseName: Environmental Science Database customDbUrl: eissn: 1476-4687 dateEnd: 20241207 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: PATMY dateStart: 19880107 isFulltext: true titleUrlDefault: http://search.proquest.com/environmentalscience providerName: ProQuest – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 1476-4687 dateEnd: 20241207 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: 7X7 dateStart: 19880107 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: Materials Science Database customDbUrl: eissn: 1476-4687 dateEnd: 20241207 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: KB. dateStart: 19880107 isFulltext: true titleUrlDefault: http://search.proquest.com/materialsscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Nursing & Allied Health Database customDbUrl: eissn: 1476-4687 dateEnd: 20241207 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: 7RV dateStart: 19880107 isFulltext: true titleUrlDefault: https://search.proquest.com/nahs providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest advanced technologies & aerospace journals customDbUrl: eissn: 1476-4687 dateEnd: 20241207 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: P5Z dateStart: 19880107 isFulltext: true titleUrlDefault: https://search.proquest.com/hightechjournals providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 1476-4687 dateEnd: 20241207 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: BENPR dateStart: 19880107 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest research library customDbUrl: eissn: 1476-4687 dateEnd: 20241207 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: M2O dateStart: 19880107 isFulltext: true titleUrlDefault: https://search.proquest.com/pqrl providerName: ProQuest – providerCode: PRVPQU databaseName: Psychology Database customDbUrl: eissn: 1476-4687 dateEnd: 20241207 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: M2M dateStart: 19880107 isFulltext: true titleUrlDefault: https://www.proquest.com/psychology providerName: ProQuest – providerCode: PRVPQU databaseName: Public Health Database customDbUrl: eissn: 1476-4687 dateEnd: 20241207 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: 8C1 dateStart: 19880107 isFulltext: true titleUrlDefault: https://search.proquest.com/publichealth providerName: ProQuest – providerCode: PRVPQU databaseName: Science Database customDbUrl: eissn: 1476-4687 dateEnd: 20241207 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: M2P dateStart: 19880107 isFulltext: true titleUrlDefault: https://search.proquest.com/sciencejournals providerName: ProQuest |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3fb9MwED6xDaS9ABu_AqMKEg8gMEtsp3ae0DptIE0t0Rio4yVKYkeLxtLSpEj895wdt1U3sRdePqmKrdS5O9_ZPn8H8FqxiOVUakK1zAjPTTVAqlCX45xmpaI5pYUtNiFGIzkex4nbcGtcWuViTrQTtZoUZo98H92gRG8Wsfjj9BcxVaPM6aorobEBW4YlgdnUvWSV4nGNhdldmgmY3G_QcUmTfmtqG2CMQ4J1x3Qj2ryZNHnt5NQ6pOMH_zuUh3DfhaL-Qac7O3BH17twz6aEFs0u7Dizb_w3jpv67SP4NCBmq5-YC5omychHmReX00lVt_5VV2kXO7QXWevPuir32kfZVaSdX-H7_MpeR2n_PIZvx0dnh5-Jq8VACi6ilhie-bLPFdpsnrG8VIqHOhMizBRnZZhHMlZ5Jlhc4opR5lEclxxDTS2VCE12FXsCm_Wk1s_A7xdhqTGMNMxqPFBcllznWV9pnApoEBUehAtBpIUjKjf1Mn6m9sCcybQTXorCS63w0sCDd8s-046m49bWewvBpM5km3QlFQ9eLR-jsZnPmtV6MjdtcIGJc2IkPHjaqcPydUwwznF55oFcU5RlA0Pkvf6kri4soTcuwWPDq-bB-4VOrf7Xv4fx_PZhvIBtavVbkJDtwWY7m-uXcLf43VbNrAcb4vS7wbGwKBHlYdiDrcHRKDnFXyeDD4jD4MQgHVr8YjHpWTuz-BUxiX5gv-TgbHj-F-I_Jcc |
| linkProvider | ProQuest |
| linkToHtml | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Nb9QwEB2VAoIL0EIhUCBIIIGo1cR21s4BIb5Kq5YVQgX1FpLYoRE0u2yyoP4pfiMzTrKrbUVvPXCO8-HkeWYcP78H8NiISGRcW8atTpnMyA2QG8RynPG0MDzjPHdmE2o41AcH8ccl-NPvhSFaZR8TXaA2o5z-kW9iGtSYzSIRvxz_ZOQaRaurvYVGC4tde_wbp2z1i523-H2fcL71bv_NNutcBVguVdQwUkwvBtIg-rJUZIUxMrSpUmFqpCjCLNKxyVIl4gLnPjqL4riQWDRZbVRIPCGB170AFzGOh0QhU5--zCklJ1Sfu006gdCbNSZKTXRf8lLAmooFi4nwVHV7mqR5YqXWJcCt6__bq7sB17pS23_Vjo0VWLLVKlx2lNe8XoWVLqzV_tNOe_vZTXj_mtFSBqMNqESi8hHT-ffxqKwa_6h1EsYTmsO08Sf2G1mfWR-xWbJmeoT380u33aY5vgWfz6Vra7BcjSp7B_xBHhYWy2RSjpOBkbqQNksHxmKo40GUexD2Hz7JOyF28gP5kThCgNBJC5YEwZI4sCSBB89n54xbGZIzW6_3QEi6kFQncxR48Gh2GIMJvda0sqMptcEJNMb8SHlwu4Xf7HZCCSlx-umBXgDmrAEJlS8eqcpDJ1geBiom3TgPNnoMz5_r3924e3Y3HsKV7f0Pe8neznD3HlzlbmwpFop1WG4mU3sfLuW_mrKePHCj1Iev543tv76cdDQ |
| linkToPdf | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Nb9QwEB2V8iEuQAuFQIEggQSi1ia2s3YOCEHLQlW06gGk3kISOzSCZpdNFtS_xq9jxkm2bCt664FznM06-zwzXr95D-CpEZHIuLaMW50ymZEbIDeI5TjjaWF4xnnuzCbUeKwPDuL9Ffjd98IQrbKPiS5Qm0lO_5EPMA1qzGaRiAdFR4vY3xm9nv5g5CBFJ629nUYLkT17_Au3b_Wr3R38rZ9xPnr3afsD6xwGWC5V1DBSTy-G0iASs1RkhTEytKlSYWqkKMIs0rHJUiXiAvdBOoviuJBYQFltVEicIYGfewkuK4Eopi717b_oJacUoLuGnUDoQY1JUxP1l3wVsL5iwXJSPFPpniVsnjq1dclwdPN_fo234EZXgvtv2jWzBiu2Woerjgqb1-uw1oW72n_eaXK_uA3v3zI64mDUmErkKh-xnn-bTsqq8Y9ah2G8oTlMG39mv5IlmvURsyVr5kf4PL90bTjN8R34fCFT24DValLZe-AP87CwWD6TopwMjNSFtFk6NBbBw4Mo9yDsQZDknUA7-YR8TxxRQOikBU6CwEkccJLAg5eLe6atPMm5ozd7UCRdqKqTE0R48GRxGYMMvda0spM5jcGNNeaCSHlwt4Xi4nFCCSlxW-qBXgLpYgAJmC9fqcpDJ2QeBiomPTkPtno8n3yvf0_j_vnTeAzXENLJx93x3gO4zt0yUywUm7DazOb2IVzJfzZlPXvkFqwPXy4a2n8AwmV8jw |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=B-cell-specific+checkpoint+molecules+that+regulate+anti-tumour+immunity&rft.jtitle=Nature+%28London%29&rft.au=Bod%2C+Lloyd&rft.au=Kye%2C+Yoon-Chul&rft.au=Shi%2C+Jingwen&rft.au=Torlai+Triglia%2C+Elena&rft.date=2023-07-13&rft.issn=1476-4687&rft.eissn=1476-4687&rft.volume=619&rft.issue=7969&rft.spage=348&rft_id=info:doi/10.1038%2Fs41586-023-06231-0&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0028-0836&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0028-0836&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0028-0836&client=summon |