NO-HYPE: a novel hydrodynamic phantom for the evaluation of MRI flow measurements

Accurate and reproducible measurement of blood flow profile is very important in many clinical investigations for diagnosing cardiovascular disorders. Given that many factors could affect human circulation, and several parameters must be set to properly evaluate blood flows with phase-contrast techn...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Medical & biological engineering & computing Ročník 59; číslo 9; s. 1889 - 1899
Hlavní autoři: Gadda, Giacomo, Cocozza, Sirio, Gambaccini, Mauro, Taibi, Angelo, Tedeschi, Enrico, Zamboni, Paolo, Palma, Giuseppe
Médium: Journal Article
Jazyk:angličtina
Vydáno: Berlin/Heidelberg Springer Berlin Heidelberg 01.09.2021
Springer Nature B.V
Témata:
Biomedical and Life Sciences
Biomedical Engineering and Bioengineering
Biomedicine
Blood circulation
Blood flow
Clinical medicine
Computer Applications
Computer programs
Design
Evaluation
Flow velocity
Hemodynamics
Human Physiology
Humans
Hydraulic equipment
Hydraulics
Hydrodynamics
Imaging
Magnetic Resonance Imaging
Medical imaging
Mimicry
Original
Original Article
Phantoms, Imaging
Physiology
Pipes
Radiology
Scanners
Sequences
Simulation
Soft tissues
Software
Stability
Synchronism
Synchronization
Waveforms
Human circulation
Blood flow simulation
Phase-contrast MRI
Hydrodynamic phantom
ISSN:0140-0118, 1741-0444, 1741-0444
On-line přístup:Získat plný text
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
Popis
Shrnutí:Accurate and reproducible measurement of blood flow profile is very important in many clinical investigations for diagnosing cardiovascular disorders. Given that many factors could affect human circulation, and several parameters must be set to properly evaluate blood flows with phase-contrast techniques, we developed an MRI-compatible hydrodynamic phantom to simulate different physiological blood flows. The phantom included a programmable hydraulic pump connected to a series of pipes immersed in a solution mimicking human soft tissues, with a blood-mimicking fluid flowing in the pipes. The pump is able to shape and control the flow by driving a piston through a dedicated software. Periodic waveforms are used as input to the pump to move the fluid into the pipes, with synchronization of the MRI sequences to the flow waveforms. A dedicated software is used to extract and analyze flow data from magnitude and phase images. The match between the nominal and the measured flows was assessed, and the scope of phantom variables useful for a reliable calibration of an MRI system was accordingly defined. Results showed that the NO-HYPE phantom is a valuable tool for the assessment of MRI scanners and sequence design for the MR evaluation of blood flows. Graphical abstract Overview of the NOvel HYdrodynamic Phantom for the Evaluation of MRI flow measurements (NO-HYPE). Left: internal of the CompuFlow 1000 MR pump unit. Right: Setting of the NO-HYPE before a MRI acquisition session. Soft tissue mimicking material is hosted in the central part of the phantom (light blue chamber). Glass pipes pass through the chamber carrying the blood mimicking fluid.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
ISSN:0140-0118
1741-0444
1741-0444
DOI:10.1007/s11517-021-02390-2