Targeted Knockdown of Overexpressed VEGFA or VEGF164 in Müller cells maintains retinal function by triggering different signaling mechanisms

Oxygen-induced retinopathy (OIR) upregulates Müller cell vascular endothelial growth factor A (VEGFA) that causes intravitreal neovascularization similar to severe retinopathy of prematurity (ROP). Safety concerns exist with anti-VEGF treatment for ROP. We evaluated long-term knockdown of Müller cel...

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Bibliographic Details
Published in:	Scientific reports Vol. 8; no. 1; pp. 2003 - 13
Main Authors:	Becker, Silke, Wang, Haibo, Simmons, Aaron B., Suwanmanee, Thipparat, Stoddard, Gregory J., Kafri, Tal, Hartnett, M. Elizabeth
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 31.01.2018 Nature Publishing Group
Subjects:	13/106 13/51 14/19 38/77 38/89 42/41 692/308 692/617 Animals Astrocytes - metabolism Brain-derived neurotrophic factor Brain-Derived Neurotrophic Factor - metabolism Cells, Cultured Electroretinograms Erythropoietin Erythropoietin - metabolism Gene Knockdown Techniques Gene Silencing Glial Cell Line-Derived Neurotrophic Factor - metabolism Humanities and Social Sciences multidisciplinary Nerve growth factor Nerve Growth Factor - metabolism Neuronal-glial interactions Neuroprotection Neurotrophin 3 Neurotrophin 3 - metabolism Rats Rats, Sprague-Dawley Retina Retina - metabolism Retina - pathology Retinopathy Retinopathy of Prematurity - metabolism Rodents Science Science (multidisciplinary) Signal Transduction Structure-function relationships Vascular endothelial growth factor Vascular Endothelial Growth Factor A - genetics Vascular Endothelial Growth Factor A - metabolism Vascularization
ISSN:	2045-2322, 2045-2322
Online Access:	Get full text
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