Copy number genome alterations are associated with treatment response and outcome in relapsed childhood ETV6/RUNX1-positive acute lymphoblastic leukemia

The clinical heterogeneity among first relapses of childhood ETV6/RUNX1-positive acute lymphoblastic leukemia indicates that further genetic alterations in leukemic cells might affect the course of salvage therapy and be of prognostic relevance. To assess the incidence and prognostic relevance of ad...

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Bibliographic Details
Published in:	Haematologica (Roma) Vol. 99; no. 4; pp. 706 - 714
Main Authors:	Bokemeyer, A., Eckert, C., Meyr, F., Koerner, G., von Stackelberg, A., Ullmann, R., Turkmen, S., Henze, G., Seeger, K.
Format:	Journal Article
Language:	English
Published:	Italy Ferrata Storti Foundation 01.04.2014
Subjects:	B-Lymphocytes - metabolism B-Lymphocytes - pathology Bone Marrow - metabolism Bone Marrow - pathology Cell Differentiation Chromosome Aberrations Chromosome Deletion Chromosomes, Human, Pair 5 Chromosomes, Human, X Core Binding Factor Alpha 2 Subunit - genetics DNA Copy Number Variations Female Follow-Up Studies Humans Male Neoplasm Recurrence, Local Oncogene Proteins, Fusion - genetics Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics Precursor Cell Lymphoblastic Leukemia-Lymphoma - mortality Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology Prognosis Remission Induction Sex Factors Treatment Outcome
ISSN:	0390-6078, 1592-8721, 1592-8721
Online Access:	Get full text
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