Benzodiazepines in the Management of Seizures and Status Epilepticus: A Review of Routes of Delivery, Pharmacokinetics, Efficacy, and Tolerability

Status epilepticus (SE) is an acute, life-threatening medical condition that requires immediate, effective therapy. Therefore, the acute care of prolonged seizures and SE is a constant challenge for healthcare professionals, in both the pre-hospital and the in-hospital settings. Benzodiazepines (BZD...

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Bibliographic Details
Published in:	CNS drugs Vol. 36; no. 9; pp. 951 - 975
Main Authors:	Kienitz, Ricardo, Kay, Lara, Beuchat, Isabelle, Gelhard, Sarah, von Brauchitsch, Sophie, Mann, Catrin, Lucaciu, Alexandra, Schäfer, Jan-Hendrik, Siebenbrodt, Kai, Zöllner, Johann-Philipp, Schubert-Bast, Susanne, Rosenow, Felix, Strzelczyk, Adam, Willems, Laurent M.
Format:	Journal Article
Language:	English
Published:	Cham Springer International Publishing 01.09.2022 Springer Nature B.V
Subjects:	Allosteric properties Anesthesia Anticonvulsants Anticonvulsants - adverse effects Benzodiazepines Benzodiazepines - adverse effects Caregivers Clonazepam Clonazepam - therapeutic use Convulsions & seizures Diazepam Diazepam - therapeutic use Drug dosages Epilepsy gamma-Aminobutyric Acid - therapeutic use Humans Intranasal administration Intravenous administration Lorazepam Lorazepam - therapeutic use Medicine Medicine & Public Health Metabolism Midazolam Mortality Neurology Neurosciences Patients Pharmacodynamics Pharmacokinetics Pharmacotherapy Psychiatry Psychopharmacology Review Review Article Seizures Seizures - drug therapy Status Epilepticus - drug therapy γ-Aminobutyric acid
ISSN:	1172-7047, 1179-1934, 1179-1934
Online Access:	Get full text
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