Staphylococcus aureus host interactions and adaptation

Invasive Staphylococcus aureus infections are common, causing high mortality, compounded by the propensity of the bacterium to develop drug resistance. S. aureus is an excellent case study of the potential for a bacterium to be commensal, colonizing, latent or disease-causing; these states defined b...

Full description

Saved in:
Bibliographic Details
Published in:Nature reviews. Microbiology Vol. 21; no. 6; pp. 380 - 395
Main Authors: Howden, Benjamin P, Giulieri, Stefano G, Wong Fok Lung, Tania, Baines, Sarah L, Sharkey, Liam K, Lee, Jean Y H, Hachani, Abderrahman, Monk, Ian R, Stinear, Timothy P
Format: Journal Article
Language:English
Published: England Nature Publishing Group 01.06.2023
Subjects:
Adaptation, Physiological
Animals
Bacteria
Drug resistance
Host-Pathogen Interactions
Humans
Immune Evasion
Immune response
Leukocytes (neutrophilic)
Mammals
Opportunist infection
Staphylococcal Infections
Staphylococcus aureus
Staphylococcus aureus - genetics
Staphylococcus infections
Vaccine development
Virulence factors
Virulence Factors - genetics
ISSN:1740-1526, 1740-1534, 1740-1534
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Invasive Staphylococcus aureus infections are common, causing high mortality, compounded by the propensity of the bacterium to develop drug resistance. S. aureus is an excellent case study of the potential for a bacterium to be commensal, colonizing, latent or disease-causing; these states defined by the interplay between S. aureus and host. This interplay is multidimensional and evolving, exemplified by the spread of S. aureus between humans and other animal reservoirs and the lack of success in vaccine development. In this Review, we examine recent advances in understanding the S. aureus-host interactions that lead to infections. We revisit the primary role of neutrophils in controlling infection, summarizing the discovery of new immune evasion molecules and the discovery of new functions ascribed to well-known virulence factors. We explore the intriguing intersection of bacterial and host metabolism, where crosstalk in both directions can influence immune responses and infection outcomes. This Review also assesses the surprising genomic plasticity of S. aureus, its dualism as a multi-mammalian species commensal and opportunistic pathogen and our developing understanding of the roles of other bacteria in shaping S. aureus colonization.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ObjectType-Review-3
content type line 23
ISSN:1740-1526
1740-1534
1740-1534
DOI:10.1038/s41579-023-00852-y