Structural biology of the multidrug and toxic compound extrusion superfamily transporters

Xenobiotic and metabolite extrusion is an important process for the proper functions of cells and their compartments, including acidic organelles. MATE (multidrug and toxic compound extrusion) is a large family of secondary active transporters involved in the transport of various compounds across ce...

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Bibliographic Details
Published in:Biochimica et biophysica acta. Biomembranes Vol. 1862; no. 12; p. 183154
Main Authors: Kusakizako, Tsukasa, Miyauchi, Hirotake, Ishitani, Ryuichiro, Nureki, Osamu
Format: Journal Article
Language:English
Published: Netherlands Elsevier B.V 01.12.2020
Subjects:
Archaea - metabolism
Archaeal Proteins - chemistry
Archaeal Proteins - classification
Archaeal Proteins - metabolism
ATP-Binding Cassette Transporters - chemistry
ATP-Binding Cassette Transporters - classification
ATP-Binding Cassette Transporters - metabolism
Crystal structure
Humans
MATE superfamily
Molecular Dynamics Simulation
Multi-drug resistance
Organic Cation Transport Proteins - chemistry
Organic Cation Transport Proteins - classification
Organic Cation Transport Proteins - metabolism
Plant Proteins - chemistry
Plant Proteins - classification
Plant Proteins - metabolism
Plants - metabolism
Protein Structure, Tertiary
Structural biology
Substrate Specificity
Transporter
MATE superfamily
Multi-drug resistance
Transporter
Structural biology
Crystal structure
ISSN:0005-2736, 1879-2642, 1879-2642
Online Access:Get full text
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Summary:Xenobiotic and metabolite extrusion is an important process for the proper functions of cells and their compartments, including acidic organelles. MATE (multidrug and toxic compound extrusion) is a large family of secondary active transporters involved in the transport of various compounds across cellular and organellar membranes, and is present in the three domains of life. The major substrates of the bacterial MATE transporters are cationic compounds, including clinically important antibiotics, and thereby MATE transporters confer multi-drug resistance to pathogenic bacteria. The plant MATE transporters are important for the accumulation of various metabolites in organelles, including vacuoles. The human MATE transporters are expressed in the brush-border membrane of the kidney, and are involved in the clearance of cationic drugs from the body. During the past decade, progress in structural biology has clarified the transport mechanism of these MATE transporters in atomic detail. The present review summarizes the reported structures of MATE family transporters, along with their structure-guided functional analyses. This integrated view of the structures of MATE transporters provides novel insights into their transport mechanism. •MATE (multidrug and toxic compound extrusion) is a large family of secondary active transporters.•MATE is involved in the transport of various xenobiotics and metabolites across cellular and organellar membranes.•The present review summarizes the reported structures of MATE family transporters.•The integrated view of the structures of MATE transporters provides novel insights into their transport mechanism.
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ISSN:0005-2736
1879-2642
1879-2642
DOI:10.1016/j.bbamem.2019.183154