Breast cancer as an example of tumour heterogeneity and tumour cell plasticity during malignant progression

Heterogeneity within a tumour increases its ability to adapt to constantly changing constraints, but adversely affects a patient’s prognosis, therapy response and clinical outcome. Intratumoural heterogeneity results from a combination of extrinsic factors from the tumour microenvironment and intrin...

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Bibliographic Details
Published in:	British journal of cancer Vol. 125; no. 2; pp. 164 - 175
Main Authors:	Lüönd, Fabiana, Tiede, Stefanie, Christofori, Gerhard
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 20.07.2021 Nature Publishing Group
Subjects:	631/67/322 631/80/84/2176 Biomedical and Life Sciences Biomedicine Breast cancer Breast Neoplasms - genetics Breast Neoplasms - pathology Cancer Research Cell Plasticity Disease Progression Drug Resistance Drug Resistance, Neoplasm Epidemiology Epigenesis, Genetic Epigenetics Epithelial-Mesenchymal Transition Female Functional plasticity Gene expression Gene Expression Regulation, Neoplastic Gene Regulatory Networks Genetic Heterogeneity Humans Mesenchyme Metastases Microenvironments Molecular Medicine Oncology Review Review Article Tumor microenvironment Tumors
ISSN:	0007-0920, 1532-1827, 1532-1827
Online Access:	Get full text
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