Breast cancer as an example of tumour heterogeneity and tumour cell plasticity during malignant progression

Heterogeneity within a tumour increases its ability to adapt to constantly changing constraints, but adversely affects a patient’s prognosis, therapy response and clinical outcome. Intratumoural heterogeneity results from a combination of extrinsic factors from the tumour microenvironment and intrin...

Full description

Saved in:
Bibliographic Details
Published in:British journal of cancer Vol. 125; no. 2; pp. 164 - 175
Main Authors: Lüönd, Fabiana, Tiede, Stefanie, Christofori, Gerhard
Format: Journal Article
Language:English
Published: London Nature Publishing Group UK 20.07.2021
Nature Publishing Group
Subjects:
631/67/322
631/80/84/2176
Biomedical and Life Sciences
Biomedicine
Breast cancer
Breast Neoplasms - genetics
Breast Neoplasms - pathology
Cancer Research
Cell Plasticity
Disease Progression
Drug Resistance
Drug Resistance, Neoplasm
Epidemiology
Epigenesis, Genetic
Epigenetics
Epithelial-Mesenchymal Transition
Female
Functional plasticity
Gene expression
Gene Expression Regulation, Neoplastic
Gene Regulatory Networks
Genetic Heterogeneity
Humans
Mesenchyme
Metastases
Microenvironments
Molecular Medicine
Oncology
Review
Review Article
Tumor microenvironment
Tumors
ISSN:0007-0920, 1532-1827, 1532-1827
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Abstract Heterogeneity within a tumour increases its ability to adapt to constantly changing constraints, but adversely affects a patient’s prognosis, therapy response and clinical outcome. Intratumoural heterogeneity results from a combination of extrinsic factors from the tumour microenvironment and intrinsic parameters from the cancer cells themselves, including their genetic, epigenetic and transcriptomic traits, their ability to proliferate, migrate and invade, and their stemness and plasticity attributes. Cell plasticity constitutes the ability of cancer cells to rapidly reprogramme their gene expression repertoire, to change their behaviour and identities, and to adapt to microenvironmental cues. These features also directly contribute to tumour heterogeneity and are critical for malignant tumour progression. In this article, we use breast cancer as an example of the origins of tumour heterogeneity (in particular, the mutational spectrum and clonal evolution of progressing tumours) and of tumour cell plasticity (in particular, that shown by tumour cells undergoing epithelial-to-mesenchymal transition), as well as considering interclonal cooperativity and cell plasticity as sources of cancer cell heterogeneity. We review current knowledge on the functional contribution of cell plasticity and tumour heterogeneity to malignant tumour progression, metastasis formation and therapy resistance.
AbstractList Heterogeneity within a tumour increases its ability to adapt to constantly changing constraints, but adversely affects a patient’s prognosis, therapy response and clinical outcome. Intratumoural heterogeneity results from a combination of extrinsic factors from the tumour microenvironment and intrinsic parameters from the cancer cells themselves, including their genetic, epigenetic and transcriptomic traits, their ability to proliferate, migrate and invade, and their stemness and plasticity attributes. Cell plasticity constitutes the ability of cancer cells to rapidly reprogramme their gene expression repertoire, to change their behaviour and identities, and to adapt to microenvironmental cues. These features also directly contribute to tumour heterogeneity and are critical for malignant tumour progression. In this article, we use breast cancer as an example of the origins of tumour heterogeneity (in particular, the mutational spectrum and clonal evolution of progressing tumours) and of tumour cell plasticity (in particular, that shown by tumour cells undergoing epithelial-to-mesenchymal transition), as well as considering interclonal cooperativity and cell plasticity as sources of cancer cell heterogeneity. We review current knowledge on the functional contribution of cell plasticity and tumour heterogeneity to malignant tumour progression, metastasis formation and therapy resistance.
Heterogeneity within a tumour increases its ability to adapt to constantly changing constraints, but adversely affects a patient's prognosis, therapy response and clinical outcome. Intratumoural heterogeneity results from a combination of extrinsic factors from the tumour microenvironment and intrinsic parameters from the cancer cells themselves, including their genetic, epigenetic and transcriptomic traits, their ability to proliferate, migrate and invade, and their stemness and plasticity attributes. Cell plasticity constitutes the ability of cancer cells to rapidly reprogramme their gene expression repertoire, to change their behaviour and identities, and to adapt to microenvironmental cues. These features also directly contribute to tumour heterogeneity and are critical for malignant tumour progression. In this article, we use breast cancer as an example of the origins of tumour heterogeneity (in particular, the mutational spectrum and clonal evolution of progressing tumours) and of tumour cell plasticity (in particular, that shown by tumour cells undergoing epithelial-to-mesenchymal transition), as well as considering interclonal cooperativity and cell plasticity as sources of cancer cell heterogeneity. We review current knowledge on the functional contribution of cell plasticity and tumour heterogeneity to malignant tumour progression, metastasis formation and therapy resistance.Heterogeneity within a tumour increases its ability to adapt to constantly changing constraints, but adversely affects a patient's prognosis, therapy response and clinical outcome. Intratumoural heterogeneity results from a combination of extrinsic factors from the tumour microenvironment and intrinsic parameters from the cancer cells themselves, including their genetic, epigenetic and transcriptomic traits, their ability to proliferate, migrate and invade, and their stemness and plasticity attributes. Cell plasticity constitutes the ability of cancer cells to rapidly reprogramme their gene expression repertoire, to change their behaviour and identities, and to adapt to microenvironmental cues. These features also directly contribute to tumour heterogeneity and are critical for malignant tumour progression. In this article, we use breast cancer as an example of the origins of tumour heterogeneity (in particular, the mutational spectrum and clonal evolution of progressing tumours) and of tumour cell plasticity (in particular, that shown by tumour cells undergoing epithelial-to-mesenchymal transition), as well as considering interclonal cooperativity and cell plasticity as sources of cancer cell heterogeneity. We review current knowledge on the functional contribution of cell plasticity and tumour heterogeneity to malignant tumour progression, metastasis formation and therapy resistance.
Author Christofori, Gerhard
Tiede, Stefanie
Lüönd, Fabiana
Author_xml – sequence: 1
  givenname: Fabiana
  surname: Lüönd
  fullname: Lüönd, Fabiana
  organization: Department of Biomedicine, University of Basel
– sequence: 2
  givenname: Stefanie
  surname: Tiede
  fullname: Tiede, Stefanie
  organization: Department of Biomedicine, University of Basel
– sequence: 3
  givenname: Gerhard
  orcidid: 0000-0002-8696-9896
  surname: Christofori
  fullname: Christofori, Gerhard
  email: gerhard.christofori@unibas.ch
  organization: Department of Biomedicine, University of Basel
BackLink https://www.ncbi.nlm.nih.gov/pubmed/33824479$$D View this record in MEDLINE/PubMed
BookMark eNp9kUtv1TAQhS1URG8Lf4AFssSGTcCvxPYGCSoelSp1U9aW7UxuXRI72ElF_z2-3LbQLrqyrPnO0Zw5R-ggpggIvabkPSVcfSiCCto1hNGGUM5UI5-hDW05a6hi8gBtCCGyIZqRQ3RUylX9aqLkC3TIuWJCSL1BPz9nsGXB3kYPGduCbcTw207zCDgNeFmntGZ8CQvktIUIYbmpSH838DCOeB6rRfC7Ub_mELd4smPYRhsXPFdZhlJCii_R88GOBV7dvsfox9cvFyffm7Pzb6cnn84aL6RYGt-1XFvat1TYzjnHXE9bIUB6bb3jzHPZOjE4Jp1wVPfA5WBFp52TnvpB8WP0ce87r26C3kNcsh3NnMNk841JNpiHkxguzTZdG8U0Ey2pBu9uDXL6tUJZzBTKLqmNkNZiWEt0RzomaEXfPkKv6llijVeplnOtmOoq9eb_je5XueuhAmwP-JxKyTDcI5SYXdlmX7apZZu_ZRtZReqRqFZgl3rpmiqMT0v5XlrmXV-Q_639hOoP_CnBBg
CitedBy_id crossref_primary_10_1159_000539478
crossref_primary_10_1016_j_cyto_2022_156061
crossref_primary_10_3389_fimmu_2025_1573365
crossref_primary_10_1007_s11033_024_09320_z
crossref_primary_10_1016_j_ccell_2025_06_019
crossref_primary_10_1007_s12094_021_02704_8
crossref_primary_10_1016_j_eanmj_2025_100004
crossref_primary_10_1016_j_tranon_2024_101985
crossref_primary_10_1172_JCI164227
crossref_primary_10_3390_cancers14194955
crossref_primary_10_7717_peerj_18733
crossref_primary_10_3389_fonc_2023_1167567
crossref_primary_10_3390_pharmaceutics16091120
crossref_primary_10_1016_j_molstruc_2025_141662
crossref_primary_10_1007_s12282_024_01645_8
crossref_primary_10_1007_s10552_022_01574_x
crossref_primary_10_1038_s41418_024_01430_2
crossref_primary_10_3389_fimmu_2025_1609621
crossref_primary_10_3389_fonc_2024_1342346
crossref_primary_10_1038_s41698_023_00472_y
crossref_primary_10_3389_fonc_2023_1210125
crossref_primary_10_3390_molecules27061762
crossref_primary_10_1186_s12885_023_10634_7
crossref_primary_10_1158_0008_5472_CAN_22_3667
crossref_primary_10_1016_j_canlet_2022_215850
crossref_primary_10_3389_fonc_2023_1292211
crossref_primary_10_3390_cancers14030474
crossref_primary_10_3390_cancers13236013
crossref_primary_10_3390_cancers16020375
crossref_primary_10_1111_jcmm_18059
crossref_primary_10_3389_fphar_2025_1640192
crossref_primary_10_3390_ijms24021622
crossref_primary_10_3390_jcm12072648
crossref_primary_10_2174_0113816128306053240604074142
crossref_primary_10_1002_VIW_20250092
crossref_primary_10_1038_s41419_023_06059_6
crossref_primary_10_1016_j_jddst_2024_105750
crossref_primary_10_1016_j_jff_2024_106224
crossref_primary_10_1186_s41747_022_00298_6
crossref_primary_10_1016_j_bioorg_2025_108442
crossref_primary_10_1186_s12951_024_02462_z
crossref_primary_10_1016_j_ctarc_2021_100505
crossref_primary_10_1038_s41698_025_00882_0
crossref_primary_10_1186_s13073_023_01256_6
crossref_primary_10_1002_advs_202413527
crossref_primary_10_3390_cancers14030587
crossref_primary_10_3390_cancers13215325
crossref_primary_10_1186_s13058_023_01658_9
crossref_primary_10_1016_j_bspc_2024_107410
crossref_primary_10_7717_peerj_17861
crossref_primary_10_1002_cnr2_70065
crossref_primary_10_3390_ijms25147752
crossref_primary_10_3390_ijms23179617
crossref_primary_10_3389_fphys_2023_1188502
crossref_primary_10_1007_s10555_022_10025_7
crossref_primary_10_3389_fonc_2023_1041688
crossref_primary_10_1007_s10549_024_07447_y
crossref_primary_10_1038_s41523_023_00590_7
crossref_primary_10_1016_j_snb_2022_133199
crossref_primary_10_1007_s13206_024_00169_9
crossref_primary_10_3389_fonc_2022_1000036
crossref_primary_10_1186_s12967_024_06011_y
crossref_primary_10_1002_cbf_3868
crossref_primary_10_3390_ijms26041766
crossref_primary_10_1080_17501911_2025_2542113
crossref_primary_10_1007_s10555_024_10195_6
crossref_primary_10_3390_cancers14030818
crossref_primary_10_1038_s41423_023_01013_0
crossref_primary_10_3390_cancers16061173
crossref_primary_10_2147_IJN_S460874
crossref_primary_10_1016_j_pbiomolbio_2022_09_009
crossref_primary_10_1038_s41598_024_61908_4
crossref_primary_10_3390_cancers13246352
crossref_primary_10_3390_cancers14041023
crossref_primary_10_4252_wjsc_v16_i2_207
crossref_primary_10_1002_cbf_3996
crossref_primary_10_1016_j_biopha_2023_114732
crossref_primary_10_1038_s41417_022_00485_y
crossref_primary_10_1016_j_mri_2024_05_002
crossref_primary_10_1016_j_semcancer_2021_12_011
crossref_primary_10_3390_ijms22147721
crossref_primary_10_3389_fonc_2023_1230647
crossref_primary_10_3390_cancers15010324
crossref_primary_10_3390_ijms252313029
crossref_primary_10_1002_mog2_84
crossref_primary_10_3390_cancers14020452
crossref_primary_10_1016_j_canlet_2022_215935
crossref_primary_10_1148_radiol_222830
crossref_primary_10_1155_2024_2582341
crossref_primary_10_1007_s00018_023_04902_9
crossref_primary_10_3390_life11111190
crossref_primary_10_3390_diagnostics13182946
crossref_primary_10_1016_j_jconrel_2024_07_013
crossref_primary_10_1007_s10911_023_09551_z
crossref_primary_10_1088_1758_5090_ad9b50
crossref_primary_10_1007_s00210_024_03542_5
crossref_primary_10_1007_s10585_024_10284_4
crossref_primary_10_3892_br_2024_1884
crossref_primary_10_1097_CCO_0000000000001057
crossref_primary_10_1016_j_jconrel_2022_04_014
crossref_primary_10_1016_j_nutres_2025_02_003
crossref_primary_10_1016_j_ijbiomac_2025_142870
crossref_primary_10_1007_s10911_022_09521_x
crossref_primary_10_1016_j_ctrv_2023_102521
crossref_primary_10_1016_j_jss_2023_11_073
crossref_primary_10_3389_fimmu_2024_1457491
crossref_primary_10_3389_pore_2022_1610592
crossref_primary_10_61186_rbmb_12_1_83
crossref_primary_10_1007_s11831_025_10374_w
crossref_primary_10_1016_j_biopha_2023_114546
crossref_primary_10_1016_j_abb_2024_110039
crossref_primary_10_3390_cancers17010159
crossref_primary_10_1016_j_biocel_2024_106688
crossref_primary_10_1007_s12013_024_01609_x
crossref_primary_10_1186_s13046_024_03258_7
crossref_primary_10_3390_cancers13225616
crossref_primary_10_3390_ijms241814026
crossref_primary_10_1038_s41598_022_24511_z
crossref_primary_10_1016_j_jbi_2025_104907
crossref_primary_10_1186_s13046_023_02782_2
crossref_primary_10_1016_j_yexcr_2024_114188
crossref_primary_10_1002_prca_70018
crossref_primary_10_1016_j_jddst_2024_105375
crossref_primary_10_1038_s41586_022_04758_2
crossref_primary_10_1002_cai2_88
crossref_primary_10_1016_j_cyto_2024_156698
crossref_primary_10_1016_j_ejrad_2022_110646
crossref_primary_10_1016_j_ceb_2024_102422
crossref_primary_10_1177_11782234241285648
crossref_primary_10_1007_s12282_024_01579_1
crossref_primary_10_3390_ijms241813726
crossref_primary_10_1128_spectrum_03622_22
crossref_primary_10_2174_0115701808255183230922110002
crossref_primary_10_1007_s12272_022_01414_1
crossref_primary_10_1038_s41598_025_01984_2
crossref_primary_10_1186_s12885_022_10383_z
crossref_primary_10_3390_cancers13194922
crossref_primary_10_15252_emmm_202114283
crossref_primary_10_3390_cancers14122848
crossref_primary_10_3390_cancers16223849
crossref_primary_10_1177_11782234231158270
crossref_primary_10_2478_raon_2024_0030
crossref_primary_10_1016_j_modpat_2023_100403
crossref_primary_10_1016_j_bbagen_2024_130577
crossref_primary_10_1177_09287329241296354
crossref_primary_10_1038_s41598_023_45074_7
crossref_primary_10_3390_ijms232113551
crossref_primary_10_1016_j_prp_2023_154482
crossref_primary_10_1007_s10555_023_10144_9
crossref_primary_10_1002_lsm_23651
crossref_primary_10_1136_jitc_2024_010871
crossref_primary_10_3390_healthcare11030321
crossref_primary_10_3390_biology13070512
crossref_primary_10_3390_cancers14030515
crossref_primary_10_1186_s40001_024_01901_9
crossref_primary_10_1007_s10565_024_09850_z
crossref_primary_10_1093_nar_gkac892
crossref_primary_10_1016_j_semcancer_2022_03_008
crossref_primary_10_7759_cureus_72919
crossref_primary_10_1007_s00330_023_09560_w
crossref_primary_10_1016_j_clicom_2023_06_002
crossref_primary_10_3390_genes16030302
crossref_primary_10_1158_1541_7786_MCR_24_1045
crossref_primary_10_1016_j_eurpolymj_2024_113426
crossref_primary_10_3390_ijms232012628
crossref_primary_10_1016_j_isci_2023_108322
crossref_primary_10_1186_s12967_025_06126_w
crossref_primary_10_3390_ijms241411791
crossref_primary_10_1038_s41598_025_97071_7
crossref_primary_10_3390_biom15081067
crossref_primary_10_1063_5_0246495
crossref_primary_10_1038_s41523_025_00725_y
crossref_primary_10_1259_bjr_20210702
crossref_primary_10_1126_sciadv_adt1851
crossref_primary_10_3390_cancers14184418
crossref_primary_10_3390_ijms241512337
crossref_primary_10_1186_s12885_025_14249_y
crossref_primary_10_1038_s41467_024_47932_y
crossref_primary_10_2147_BCTT_S520532
crossref_primary_10_1007_s12010_023_04734_0
crossref_primary_10_1007_s10549_024_07316_8
crossref_primary_10_1111_jcmm_18275
crossref_primary_10_3390_cancers14174080
crossref_primary_10_1016_j_cpccr_2022_100206
crossref_primary_10_1016_j_neo_2024_101059
crossref_primary_10_1002_adhm_202301137
crossref_primary_10_1016_j_mri_2025_110370
crossref_primary_10_3390_ijms26030900
crossref_primary_10_1016_j_heliyon_2024_e31137
crossref_primary_10_3390_ijms25073932
crossref_primary_10_1155_2022_9390912
crossref_primary_10_3390_cancers14163876
crossref_primary_10_1245_s10434_023_14715_6
crossref_primary_10_1038_s43856_023_00414_6
crossref_primary_10_1038_s41417_023_00618_x
crossref_primary_10_3390_ijms26062605
crossref_primary_10_1016_j_adcanc_2022_100079
crossref_primary_10_1038_s41416_024_02658_y
crossref_primary_10_3390_molecules30112274
crossref_primary_10_1038_s41598_024_63679_4
crossref_primary_10_4103_njcp_njcp_161_24
crossref_primary_10_3390_ijms241411861
crossref_primary_10_1016_S0007_4551_21_00636_6
crossref_primary_10_1016_j_heliyon_2024_e34506
crossref_primary_10_1080_14737159_2025_2482639
crossref_primary_10_1080_13543784_2021_1983542
crossref_primary_10_3389_fonc_2022_943800
crossref_primary_10_1038_s41467_024_50071_z
crossref_primary_10_3389_fonc_2023_1170264
crossref_primary_10_1038_s41598_023_32579_4
crossref_primary_10_3390_biomedicines10030725
crossref_primary_10_4274_ejbh_galenos_2024_2024_4_3
crossref_primary_10_3233_BD_230011
crossref_primary_10_3390_cancers13235999
crossref_primary_10_1186_s13058_023_01690_9
crossref_primary_10_1016_j_sjbs_2021_07_046
crossref_primary_10_3390_ph16060899
crossref_primary_10_2174_0113816128343266241230045019
crossref_primary_10_3390_ijms25179482
crossref_primary_10_1016_j_lfs_2024_122939
crossref_primary_10_1016_j_asoc_2024_111379
crossref_primary_10_3390_cancers14133115
crossref_primary_10_1002_iub_70019
crossref_primary_10_1007_s11082_025_08445_0
crossref_primary_10_3389_fonc_2022_977226
crossref_primary_10_1016_j_ctrv_2022_102496
crossref_primary_10_1038_s41416_022_01911_6
Cites_doi 10.1038/s41388-019-0899-y
10.1158/0008-5472.CAN-14-3476
10.1038/nprot.2016.138
10.1038/nature13556
10.1038/nature16064
10.1016/j.cell.2011.05.040
10.1016/j.cell.2013.11.029
10.1038/nature10694
10.1038/nm.3121
10.1038/s41572-019-0111-2
10.1038/nature14897
10.1038/labinvest.2012.91
10.1158/2159-8290.CD-12-0462
10.1038/nature11412
10.1038/nrc3726
10.1038/nmeth.2639
10.1038/nature12627
10.1016/j.cell.2011.02.013
10.1038/nature03799
10.1038/s41467-018-07130-z
10.1016/j.cell.2017.12.007
10.1038/nature22816
10.1016/j.stem.2015.08.014
10.1038/nature13187
10.1186/s12885-015-1386-7
10.1038/nrc3261
10.1038/nm.3915
10.1038/nrc.2017.126
10.1016/j.ccr.2012.10.012
10.1038/nrc3971
10.1038/nature14665
10.1073/pnas.1618091114
10.1016/j.ccell.2018.12.002
10.1038/nature10983
10.1038/nature10762
10.1038/s41586-019-0915-y
10.1038/s41586-018-0040-3
10.1038/ncb1998
10.1038/nature11154
10.1016/j.canlet.2019.10.013
10.1016/j.molonc.2010.11.003
10.1038/s41568-018-0083-7
10.1038/s41467-019-08595-2
10.1186/bcr3687
10.1038/415530a
10.1186/bcr2635
10.1016/j.cell.2016.06.028
10.1016/j.cell.2009.11.025
10.1016/j.stem.2018.11.011
10.1038/nature15260
10.1016/j.cell.2012.04.024
10.1038/nature09807
10.1016/j.devcel.2018.05.025
10.1016/j.cell.2014.07.013
10.1038/s41588-020-0628-z
10.1016/j.cell.2008.03.027
10.1038/s41556-018-0196-y
10.1038/508052a
10.1158/0008-5472.CAN-11-1818
10.1016/j.cell.2013.06.005
10.1038/nri3789
10.1016/j.stem.2020.02.008
10.1002/path.4540
10.1016/j.ceb.2016.07.005
10.1038/nature15748
10.1038/nature08489
10.1038/s41556-019-0353-y
10.1038/nrc.2017.118
10.1158/0008-5472.CAN-07-2148
10.1038/nature10933
10.1016/j.cell.2012.04.023
10.1038/nm.3886
10.1016/j.ccr.2012.09.022
10.1038/nature09515
10.1038/s41467-018-07406-4
10.1016/j.tcb.2018.12.001
10.1158/0008-5472.CAN-14-0923
10.1038/s41467-019-10269-y
10.1038/nature14669
10.1016/j.celrep.2019.10.107
10.1016/j.celrep.2015.11.025
10.1038/s41467-017-02481-5
10.1186/bcr3217
10.1038/s41556-019-0346-x
10.1016/j.cell.2011.11.016
10.1016/j.ccell.2016.07.009
10.1016/S1535-6108(03)00132-6
10.1038/onc.2014.475
10.1182/blood-2003-08-2807
10.1038/ncb3513
10.1038/s41568-019-0149-1
10.1016/j.ccell.2019.02.010
10.1038/nrc1388
10.1002/path.4345
10.1016/S1470-2045(07)70140-7
10.1016/j.cell.2011.07.026
10.1038/s41586-019-1019-4
10.1038/s41577-019-0218-4
10.1038/nature14403
10.1038/nmeth.3370
10.1016/j.ajpath.2017.04.022
10.1084/jem.20181827
10.1073/pnas.1508541113
10.1126/science.959840
10.1016/j.celrep.2018.04.007
10.1038/35021093
10.1016/j.cell.2017.01.018
10.1186/s13073-020-00728-3
10.1158/0008-5472.CAN-12-2217
10.1016/j.celrep.2018.08.053
10.1016/j.ccr.2014.03.021
10.1038/s41556-018-0236-7
10.1038/nrc2618
10.1038/nature12626
10.1038/nm.3394
10.1016/j.cell.2018.11.046
10.1101/gad.242511.114
10.3389/fonc.2018.00381
10.1038/nature09460
10.1038/nature14347
10.1016/j.devcel.2018.05.027
10.1016/j.molcel.2015.10.031
10.1038/ncomms6871
10.1016/0022-5193(82)90388-5
10.1038/nprot.2017.003
10.1016/j.celrep.2016.02.034
10.1038/ncb1658
10.1126/science.1228522
10.1158/0008-5472.CAN-14-3363
10.1016/j.cell.2011.09.024
10.1016/j.celrep.2013.11.014
10.1038/s41568-019-0209-6
10.1038/nature15742
10.1038/nature12628
10.1038/nprot.2014.006
10.1038/nrclinonc.2016.144
10.15252/emmm.201809085
10.1038/s41586-019-1526-3
10.1038/s41580-020-0237-9
10.1098/rsif.2017.0512
ContentType Journal Article
Copyright The Author(s) 2021
2021. The Author(s).
The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Copyright_xml – notice: The Author(s) 2021
– notice: 2021. The Author(s).
– notice: The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
DBID C6C
AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
3V.
7RV
7TO
7U9
7X7
7XB
88E
8AO
8C1
8FE
8FH
8FI
8FJ
8FK
ABUWG
AFKRA
AN0
AZQEC
BBNVY
BENPR
BHPHI
CCPQU
DWQXO
FYUFA
GHDGH
GNUQQ
H94
HCIFZ
K9.
KB0
LK8
M0S
M1P
M7P
NAPCQ
PHGZM
PHGZT
PJZUB
PKEHL
PPXIY
PQEST
PQGLB
PQQKQ
PQUKI
PRINS
7X8
5PM
DOI 10.1038/s41416-021-01328-7
DatabaseName Springer Nature OA Free Journals
CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
ProQuest Central (Corporate)
Nursing & Allied Health Database
Oncogenes and Growth Factors Abstracts
Virology and AIDS Abstracts
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
ProQuest Pharma Collection
Public Health Database
ProQuest SciTech Collection
ProQuest Natural Science Collection
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni Edition)
ProQuest Central UK/Ireland
British Nursing Database
ProQuest Central Essentials
Biological Science Collection
ProQuest Central
Natural Science Collection
ProQuest One Community College
ProQuest Central Korea
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
AIDS and Cancer Research Abstracts
SciTech Premium Collection
ProQuest Health & Medical Complete (Alumni)
Nursing & Allied Health Database (Alumni Edition)
ProQuest Biological Science Collection
Health & Medical Collection (Alumni Edition)
Medical Database
Biological Science Database
Nursing & Allied Health Premium
ProQuest Central Premium
ProQuest One Academic (New)
ProQuest Health & Medical Research Collection
ProQuest One Academic Middle East (New)
ProQuest One Health & Nursing
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Applied & Life Sciences
ProQuest One Academic (retired)
ProQuest One Academic UKI Edition
ProQuest Central China
MEDLINE - Academic
PubMed Central (Full Participant titles)
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
ProQuest Central Student
Oncogenes and Growth Factors Abstracts
ProQuest One Academic Middle East (New)
ProQuest Central Essentials
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
SciTech Premium Collection
ProQuest One Community College
ProQuest One Health & Nursing
ProQuest Natural Science Collection
ProQuest Pharma Collection
ProQuest Central China
ProQuest Central
ProQuest One Applied & Life Sciences
ProQuest Health & Medical Research Collection
Health Research Premium Collection
Health and Medicine Complete (Alumni Edition)
Natural Science Collection
ProQuest Central Korea
Health & Medical Research Collection
Biological Science Collection
AIDS and Cancer Research Abstracts
ProQuest Central (New)
ProQuest Medical Library (Alumni)
ProQuest Public Health
Virology and AIDS Abstracts
ProQuest Biological Science Collection
ProQuest One Academic Eastern Edition
British Nursing Index with Full Text
ProQuest Nursing & Allied Health Source
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
Biological Science Database
ProQuest SciTech Collection
ProQuest Hospital Collection (Alumni)
Nursing & Allied Health Premium
ProQuest Health & Medical Complete
ProQuest Medical Library
ProQuest One Academic UKI Edition
ProQuest Nursing & Allied Health Source (Alumni)
ProQuest One Academic
ProQuest One Academic (New)
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList CrossRef
MEDLINE - Academic

ProQuest Central Student

MEDLINE
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: 7RV
  name: Nursing & Allied Health Database
  url: https://search.proquest.com/nahs
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
EISSN 1532-1827
EndPage 175
ExternalDocumentID PMC8292450
33824479
10_1038_s41416_021_01328_7
Genre Research Support, Non-U.S. Gov't
Journal Article
Review
GrantInformation_xml – fundername: Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (Swiss National Science Foundation)
  grantid: SystemsX.ch MetastasiX
  funderid: https://doi.org/10.13039/501100001711
– fundername: ;
  grantid: SystemsX.ch MetastasiX
GroupedDBID ---
0R~
23N
36B
39C
4.4
406
53G
5GY
5RE
6J9
70F
7RV
7X7
88E
8AO
8C1
8FI
8FJ
8R4
8R5
AACDK
AANZL
AASML
AATNV
AAWTL
AAYZH
AAZLF
ABAKF
ABLJU
ABOCM
ABUWG
ABZZP
ACAOD
ACGFO
ACGFS
ACKTT
ACPRK
ACRQY
ACZOJ
ADBBV
ADFRT
ADHDB
AEFQL
AEJRE
AEMSY
AENEX
AEVLU
AEXYK
AFBBN
AFKRA
AFRAH
AFSHS
AGAYW
AGHAI
AGQEE
AHMBA
AHSBF
AIGIU
AILAN
AJRNO
ALFFA
ALMA_UNASSIGNED_HOLDINGS
AMYLF
AN0
AOIJS
ASPBG
AVWKF
AXYYD
AZFZN
BAWUL
BBNVY
BENPR
BHPHI
BKEYQ
BKKNO
BNQBC
BPHCQ
BVXVI
C6C
CCPQU
CS3
DIK
DNIVK
DPUIP
DU5
E3Z
EAP
EBLON
EBS
EE.
EIOEI
EMB
ESX
EX3
F5P
FDQFY
FEDTE
FERAY
FIGPU
FRJ
FSGXE
FYUFA
GX1
HCIFZ
HMCUK
HVGLF
HYE
HZ~
IH2
IWAJR
JSO
JZLTJ
KQ8
M1P
M7P
NAPCQ
NQJWS
O9-
OK1
P2P
PQQKQ
PROAC
PSQYO
Q2X
RNT
RNTTT
ROL
RPM
SNX
SNYQT
SOHCF
SOJ
SRMVM
SWTZT
TAOOD
TBHMF
TDRGL
TR2
UKHRP
W2D
WH7
WOW
~02
AAFWJ
AAYXX
ABBRH
ABDBE
ABFSG
ABRTQ
ACSTC
AEZWR
AFDZB
AFFHD
AFHIU
AHWEU
AIXLP
ATHPR
AYFIA
CITATION
PHGZM
PHGZT
PJZUB
PPXIY
PQGLB
-Q-
.55
.GJ
3V.
8WZ
A6W
ABAWZ
ABDBF
ACUHS
AI.
B0M
CAG
CGR
COF
CUY
CVF
EAD
EAS
EBC
EBD
ECM
EIF
EJD
EMK
EMOBN
EPL
FIZPM
J5H
M41
NAO
NPM
SV3
TUS
UDS
VH1
X7M
Y6R
ZGI
~8M
7TO
7U9
7XB
8FE
8FH
8FK
AZQEC
DWQXO
GNUQQ
H94
K9.
LK8
PKEHL
PQEST
PQUKI
PRINS
7X8
PUEGO
5PM
ID FETCH-LOGICAL-c474t-c6539a1d514a6bbb2bd1544e7c9acb32c375b4fb27b4b19de37fa469bb7c1cf83
IEDL.DBID M7P
ISICitedReferencesCount 285
ISICitedReferencesURI http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000637479300002&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN 0007-0920
1532-1827
IngestDate Tue Nov 04 01:55:31 EST 2025
Thu Oct 02 09:21:36 EDT 2025
Tue Oct 07 05:11:45 EDT 2025
Wed Feb 19 02:23:54 EST 2025
Sat Nov 29 06:35:28 EST 2025
Tue Nov 18 22:26:26 EST 2025
Fri Feb 21 02:39:34 EST 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 2
Language English
License 2021. The Author(s).
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c474t-c6539a1d514a6bbb2bd1544e7c9acb32c375b4fb27b4b19de37fa469bb7c1cf83
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ObjectType-Review-3
content type line 23
ORCID 0000-0002-8696-9896
OpenAccessLink https://pubmed.ncbi.nlm.nih.gov/PMC8292450
PMID 33824479
PQID 2553398286
PQPubID 41855
PageCount 12
ParticipantIDs pubmedcentral_primary_oai_pubmedcentral_nih_gov_8292450
proquest_miscellaneous_2509606241
proquest_journals_2553398286
pubmed_primary_33824479
crossref_primary_10_1038_s41416_021_01328_7
crossref_citationtrail_10_1038_s41416_021_01328_7
springer_journals_10_1038_s41416_021_01328_7
PublicationCentury 2000
PublicationDate 2021-07-20
PublicationDateYYYYMMDD 2021-07-20
PublicationDate_xml – month: 07
  year: 2021
  text: 2021-07-20
  day: 20
PublicationDecade 2020
PublicationPlace London
PublicationPlace_xml – name: London
– name: England
PublicationTitle British journal of cancer
PublicationTitleAbbrev Br J Cancer
PublicationTitleAlternate Br J Cancer
PublicationYear 2021
Publisher Nature Publishing Group UK
Nature Publishing Group
Publisher_xml – name: Nature Publishing Group UK
– name: Nature Publishing Group
References Picelli, Faridani, Bjorklund, Winberg, Sagasser, Sandberg (CR135) 2014; 9
Shah, Morin, Khattra, Prentice, Pugh, Burleigh (CR19) 2009; 461
Merino, Weber, Serrano, Vaillant, Liu, Pal (CR34) 2019; 10
Cheung, Padmanaban, Silvestri, Schipper, Cohen, Fairchild (CR70) 2016; 113
Mani, Guo, Liao, Eaton, Ayyanan, Zhou (CR55) 2008; 133
Gilkes, Semenza, Wirtz (CR94) 2014; 14
Lawson, Kessenbrock, Davis, Pervolarakis, Werb (CR13) 2018; 20
Goetz, Minguet, Navarro-Lerida, Lazcano, Samaniego, Calvo (CR78) 2011; 146
Tabassum, Polyak (CR76) 2015; 15
Potts, Krueger, Landis, Eberhard, Young, Schmechel (CR130) 2012; 92
Yang, Cao, Liu, He, Du, Zhang (CR108) 2019; 38
Hu, Li, Ma, Curtis (CR97) 2020; 52
Title, Hong, Pires, Hasenohrl, Godbersen, Stokar-Regenscheit (CR125) 2018; 9
Koren, Reavie, Couto, De Silva, Stadler, Roloff (CR62) 2015; 525
Stemmler, Eccles, Brabletz, Brabletz (CR127) 2019; 21
Dang, Prechtl, Pearson (CR80) 2011; 71
Fischer, Durrans, Lee, Sheng, Li, Wong (CR123) 2015; 527
Perou, Sorlie, Eisen, van de Rijn, Jeffrey, Rees (CR6) 2000; 406
Ellis, Perou (CR9) 2013; 3
Wellner, Schubert, Burk, Schmalhofer, Zhu, Sonntag (CR56) 2009; 11
Koren, Bentires-Alj (CR2) 2015; 60
Brooks, Burness, Wicha (CR12) 2015; 17
CR47
Archetti, Pienta (CR72) 2019; 19
Stankic, Pavlovic, Chin, Brogi, Padua, Norton (CR116) 2013; 5
Junttila, de Sauvage (CR74) 2013; 501
Echeverria, Powell, Seth, Ge, Carugo, Bristow (CR33) 2018; 9
Campbell, Yachida, Mudie, Stephens, Pleasance, Stebbings (CR27) 2010; 467
Nik-Zainal, Alexandrov, Wedge, Van Loo, Greenman, Raine (CR29) 2012; 149
Tata, Rajagopal (CR44) 2016; 43
Shah, Roth, Goya, Oloumi, Ha, Zhao (CR21) 2012; 486
Xu, Lee, Feng, Xu, Bu, Li (CR126) 2017; 114
Kalbasi, Ribas (CR93) 2020; 20
Greaves, Maley (CR25) 2012; 481
Cleary, Leonard, Gestl, Gunther (CR66) 2014; 508
Weidenfeld, Barkan (CR120) 2018; 8
Curtis, Shah, Chin, Turashvili, Rueda, Dunning (CR20) 2012; 486
Gundem, Van Loo, Kremeyer, Alexandrov, Tubio, Papaemmanuil (CR69) 2015; 520
Navin, Kendall, Troge, Andrews, Rodgers, McIndoo (CR18) 2011; 472
Prat, Perou (CR8) 2011; 5
Shaked (CR139) 2019; 19
Paget (CR136) 1889; 8
Mohme, Riethdorf, Pantel (CR91) 2017; 14
Tsai, Donaher, Murphy, Chau, Yang (CR102) 2012; 22
Ombrato, Malanchi (CR89) 2019; 21
Jiang, Zhan (CR92) 2020; 468
Pastushenko, Brisebarre, Sifrim, Fioramonti, Revenco, Boumahdi (CR48) 2018; 556
Reichert, Bakir, Moreira, Pitarresi, Feldmann, Simon (CR121) 2018; 45
Campbell, Rossi, Adams, Pitsidianaki, Barriga, Garcia-Gerique (CR104) 2019; 10
Ye, Brabletz, Kang, Longmore, Nieto, Stanger (CR128) 2017; 547
Szczerba, Castro-Giner, Vetter, Krol, Gkountela, Landin (CR90) 2019; 566
Kitamura, Qian, Pollard (CR65) 2015; 15
Hanahan, Weinberg (CR141) 2011; 144
Lewis, Harney, Pollard (CR85) 2016; 30
Prat, Parker, Karginova, Fan, Livasy, Herschkowitz (CR7) 2010; 12
Nguyen, Pellacani, Lefort, Kannan, Osako, Makarem (CR32) 2015; 528
Arwert, Harney, Entenberg, Wang, Sahai, Pollard (CR87) 2018; 23
Nowell (CR26) 1976; 194
Yachida, Jones, Bozic, Antal, Leary, Fu (CR28) 2010; 467
Trimboli, Fukino, de Bruin, Wei, Shen, Tanner (CR64) 2008; 68
Harbeck, Penault-Llorca, Cortes, Gnant, Houssami, Poortmans (CR1) 2019; 5
Melchor, Molyneux, Mackay, Magnay, Atienza, Kendrick (CR3) 2014; 233
Nieto, Huang, Jackson, Thiery (CR45) 2016; 166
Chaffer, Marjanovic, Lee, Bell, Kleer, Reinhardt (CR58) 2013; 154
Minn, Gupta, Siegel, Bos, Shu, Giri (CR96) 2005; 436
Yu, Bardia, Wittner, Stott, Smas, Ting (CR111) 2013; 339
Krebs, Mitschke, Lasierra Losada, Schmalhofer, Boerries, Busch (CR50) 2017; 19
Marusyk, Tabassum, Altrock, Almendro, Michor, Polyak (CR77) 2014; 514
Friedmann Angeli, Krysko, Conrad (CR140) 2019; 19
Gkountela, Castro-Giner, Szczerba, Vetter, Landin, Scherrer (CR100) 2019; 176
Granit, Masury, Condiotti, Fixler, Gabai, Glikman (CR61) 2018; 24
Malanchi, Santamaria-Martinez, Susanto, Peng, Lehr, Delaloye (CR82) 2011; 481
Bornes, van Scheppingen, Beerling, Schelfhorst, Ellenbroek, Seinstra (CR113) 2019; 29
Su, Liu, Chen, Chen, Chen, He (CR84) 2014; 25
Fumagalli, Oost, Kester, Morgner, Bornes, Bruens (CR119) 2020; 26
Macaulay, Haerty, Kumar, Li, Hu, Teng (CR132) 2015; 12
Bedard, Hansen, Ratain, Siu (CR11) 2013; 501
Kang, Siegel, Shu, Drobnjak, Kakonen, Cordón-Cardo (CR95) 2003; 3
Banerji, Cibulskis, Rangel-Escareno, Brown, Carter, Frederick (CR24) 2012; 486
Van Keymeulen, Lee, Ousset, Brohee, Rorive, Giraddi (CR63) 2015; 525
Matise, Palmer, Ashby, Nashabi, Chytil, Aakre (CR81) 2012; 14
Macaulay, Teng, Haerty, Kumar, Ponting, Voet (CR133) 2016; 11
Wagenblast, Soto, Gutierrez-Angel, Hartl, Gable, Maceli (CR35) 2015; 520
Polzer, Klein (CR138) 2013; 19
Castro-Giner, Aceto (CR114) 2020; 12
Visvader, Stingl (CR5) 2014; 28
Casasent, Schalck, Gao, Sei, Long, Pangburn (CR38) 2018; 172
Chen, Suo, Tam, Han, Peng, Jing (CR131) 2017; 12
Janiszewska, Tabassum, Castano, Cristea, Yamamoto, Kingston (CR88) 2019; 21
Russnes, Lingjaerde, Borresen-Dale, Caldas (CR23) 2017; 187
Gaggioli, Hooper, Hidalgo-Carcedo, Grosse, Marshall, Harrington (CR79) 2007; 9
Valastyan, Weinberg (CR137) 2011; 147
Hunter, Amin, Deasy, Ha, Wakefield (CR36) 2018; 18
Linde, Casanova-Acebes, Sosa, Mortha, Rahman, Farias (CR86) 2018; 9
Ocana, Corcoles, Fabra, Moreno-Bueno, Acloque, Vega (CR101) 2012; 22
Beerling, Seinstra, de Wit, Kester, van der Velden, Maynard (CR112) 2016; 14
Marusyk, Almendro, Polyak (CR14) 2012; 12
Balkwill (CR83) 2004; 4
Aiello, Kang (CR124) 2019; 216
Tran, Luitel, Kim, Zhang, Longmore, Tran (CR115) 2014; 74
CR122
Joyce, Pollard (CR73) 2009; 9
Quail, Joyce (CR75) 2013; 19
Cheung, Gabrielson, Werb, Ewald (CR71) 2013; 155
Pastushenko, Blanpain (CR46) 2019; 29
Kim, Oskarsson, Acharyya, Nguyen, Zhang, Norton (CR68) 2009; 139
Alizadeh, Aranda, Bardelli, Blanpain, Bock, Borowski (CR16) 2015; 21
Del Pozo Martin, Park, Ramachandran, Ombrato, Calvo, Chakravarty (CR117) 2015; 13
Rios, Capaldo, Vaillant, Pal, van Ineveld, Dawson (CR49) 2019; 35
Lawson, Bhakta, Kessenbrock, Prummel, Yu, Takai (CR53) 2015; 526
Yates, Gerstung, Knappskog, Desmedt, Gundem, Van Loo (CR40) 2015; 21
CR129
Aceto, Bardia, Miyamoto, Donaldson, Wittner, Spencer (CR99) 2014; 158
Aiello, Maddipati, Norgard, Balli, Li, Yuan (CR107) 2018; 45
Bockhorn, Jain, Munn (CR109) 2007; 8
McGranahan, Swanton (CR15) 2017; 168
Swanton (CR39) 2012; 72
Nik-Zainal, Van Loo, Wedge, Alexandrov, Greenman, Lau (CR30) 2012; 149
Prindull, Zipori (CR43) 2004; 103
Brabletz, Kalluri, Nieto, Weinberg (CR52) 2018; 18
Obradovic, Hamelin, Manevski, Couto, Sethi, Coissieux (CR98) 2019; 567
Ruscetti, Quach, Dadashian, Mulholland, Wu (CR118) 2015; 75
Polyak, Marusyk (CR67) 2014; 508
Klein (CR37) 2013; 501
Desmedt, Fumagalli, Pietri, Zoppoli, Brown, Nik-Zainal (CR41) 2015; 236
Gupta, Pastushenko, Skibinski, Blanpain, Kuperwasser (CR42) 2019; 24
Ye, Tam, Shibue, Kaygusuz, Reinhardt, Ng Eaton (CR57) 2015; 525
Friedl, Alexander (CR103) 2011; 147
Bissell, Hall, Parry (CR10) 1982; 99
van 't Veer, Dai, van de Vijver, He, Hart, Mao (CR17) 2002; 415
Picelli, Bjorklund, Faridani, Sagasser, Winberg, Sandberg (CR134) 2013; 10
Gupta, Fillmore, Jiang, Shapira, Tao, Kuperwasser (CR59) 2011; 146
Skibinski, Kuperwasser (CR4) 2015; 34
Cancer Genome Atlas (CR22) 2012; 490
Nguyen, Cox, Eirew, Knapp, Pellacani, Kannan (CR31) 2014; 5
Dang, Esparza, Maine, Westcott, Pearson (CR106) 2015; 75
CR105
Zheng, Carstens, Kim, Scheible, Kaye, Sugimoto (CR51) 2015; 527
Ishay-Ronen, Diepenbruck, Kalathur, Sugiyama, Tiede, Ivanek (CR54) 2019; 35
Polioudaki, Agelaki, Chiotaki, Politaki, Mavroudis, Matikas (CR110) 2015; 15
Klevebring, Rosin, Ma, Lindberg, Czene, Kere (CR60) 2014; 16
Y Del Pozo Martin (1328_CR117) 2015; 13
KW Hunter (1328_CR36) 2018; 18
KR Fischer (1328_CR123) 2015; 527
M Greaves (1328_CR25) 2012; 481
G Gundem (1328_CR69) 2015; 520
DM Gilkes (1328_CR94) 2014; 14
F Balkwill (1328_CR83) 2004; 4
D Klevebring (1328_CR60) 2014; 16
A Kalbasi (1328_CR93) 2020; 20
S Valastyan (1328_CR137) 2011; 147
CL Chaffer (1328_CR58) 2013; 154
C Swanton (1328_CR39) 2012; 72
SA Mani (1328_CR55) 2008; 133
PB Gupta (1328_CR59) 2011; 146
S Koren (1328_CR2) 2015; 60
D Merino (1328_CR34) 2019; 10
JE Visvader (1328_CR5) 2014; 28
C Gaggioli (1328_CR79) 2007; 9
G Prindull (1328_CR43) 2004; 103
B Polzer (1328_CR138) 2013; 19
Y Shaked (1328_CR139) 2019; 19
M Mohme (1328_CR91) 2017; 14
MP Stemmler (1328_CR127) 2019; 21
C Yang (1328_CR108) 2019; 38
CA Klein (1328_CR37) 2013; 501
M Ruscetti (1328_CR118) 2015; 75
C Curtis (1328_CR20) 2012; 486
S Picelli (1328_CR134) 2013; 10
I Pastushenko (1328_CR48) 2018; 556
AA Alizadeh (1328_CR16) 2015; 21
M Archetti (1328_CR72) 2019; 19
KJ Cheung (1328_CR71) 2013; 155
PB Gupta (1328_CR42) 2019; 24
X Ye (1328_CR128) 2017; 547
U Wellner (1328_CR56) 2009; 11
T Kitamura (1328_CR65) 2015; 15
BM Szczerba (1328_CR90) 2019; 566
A Marusyk (1328_CR77) 2014; 514
LJ van 't Veer (1328_CR17) 2002; 415
M Janiszewska (1328_CR88) 2019; 21
E Beerling (1328_CR112) 2016; 14
K Polyak (1328_CR67) 2014; 508
N McGranahan (1328_CR15) 2017; 168
LR Yates (1328_CR40) 2015; 21
P Friedl (1328_CR103) 2011; 147
L Bornes (1328_CR113) 2019; 29
D Ishay-Ronen (1328_CR54) 2019; 35
MY Kim (1328_CR68) 2009; 139
N Aceto (1328_CR99) 2014; 158
MJ Ellis (1328_CR9) 2013; 3
AC Title (1328_CR125) 2018; 9
J Chen (1328_CR131) 2017; 12
NM Aiello (1328_CR124) 2019; 216
CM Perou (1328_CR6) 2000; 406
DA Lawson (1328_CR53) 2015; 526
H Polioudaki (1328_CR110) 2015; 15
N Linde (1328_CR86) 2018; 9
S Banerji (1328_CR24) 2012; 486
Y Xu (1328_CR126) 2017; 114
E Wagenblast (1328_CR35) 2015; 520
N Cancer Genome Atlas (1328_CR22) 2012; 490
A Skibinski (1328_CR4) 2015; 34
A Prat (1328_CR8) 2011; 5
NM Aiello (1328_CR107) 2018; 45
S Nik-Zainal (1328_CR30) 2012; 149
Z Hu (1328_CR97) 2020; 52
X Ye (1328_CR57) 2015; 525
M Reichert (1328_CR121) 2018; 45
D Hanahan (1328_CR141) 2011; 144
RZ Granit (1328_CR61) 2018; 24
PJ Campbell (1328_CR27) 2010; 467
AS Cleary (1328_CR66) 2014; 508
N Harbeck (1328_CR1) 2019; 5
T Brabletz (1328_CR52) 2018; 18
Y Kang (1328_CR95) 2003; 3
S Paget (1328_CR136) 1889; 8
PC Nowell (1328_CR26) 1976; 194
SJ Potts (1328_CR130) 2012; 92
I Pastushenko (1328_CR46) 2019; 29
EN Arwert (1328_CR87) 2018; 23
LV Nguyen (1328_CR32) 2015; 528
HD Tran (1328_CR115) 2014; 74
CE Lewis (1328_CR85) 2016; 30
L Ombrato (1328_CR89) 2019; 21
S Nik-Zainal (1328_CR29) 2012; 149
M Bockhorn (1328_CR109) 2007; 8
A Marusyk (1328_CR14) 2012; 12
MA Nieto (1328_CR45) 2016; 166
S Gkountela (1328_CR100) 2019; 176
MD Brooks (1328_CR12) 2015; 17
HG Russnes (1328_CR23) 2017; 187
X Zheng (1328_CR51) 2015; 527
A Fumagalli (1328_CR119) 2020; 26
JG Goetz (1328_CR78) 2011; 146
1328_CR129
MMS Obradovic (1328_CR98) 2019; 567
S Koren (1328_CR62) 2015; 525
MR Junttila (1328_CR74) 2013; 501
DF Quail (1328_CR75) 2013; 19
S Yachida (1328_CR28) 2010; 467
1328_CR122
DA Lawson (1328_CR13) 2018; 20
PL Bedard (1328_CR11) 2013; 501
AC Rios (1328_CR49) 2019; 35
SP Shah (1328_CR21) 2012; 486
C Desmedt (1328_CR41) 2015; 236
AJ Trimboli (1328_CR64) 2008; 68
JA Joyce (1328_CR73) 2009; 9
LV Nguyen (1328_CR31) 2014; 5
JH Tsai (1328_CR102) 2012; 22
DP Tabassum (1328_CR76) 2015; 15
LA Matise (1328_CR81) 2012; 14
IC Macaulay (1328_CR133) 2016; 11
S Su (1328_CR84) 2014; 25
N Navin (1328_CR18) 2011; 472
A Prat (1328_CR7) 2010; 12
K Weidenfeld (1328_CR120) 2018; 8
PR Tata (1328_CR44) 2016; 43
A Van Keymeulen (1328_CR63) 2015; 525
M Yu (1328_CR111) 2013; 339
SP Shah (1328_CR19) 2009; 461
S Picelli (1328_CR135) 2014; 9
AK Casasent (1328_CR38) 2018; 172
M Stankic (1328_CR116) 2013; 5
K Campbell (1328_CR104) 2019; 10
TT Dang (1328_CR80) 2011; 71
1328_CR105
MJ Bissell (1328_CR10) 1982; 99
AJ Minn (1328_CR96) 2005; 436
TT Dang (1328_CR106) 2015; 75
JP Friedmann Angeli (1328_CR140) 2019; 19
GV Echeverria (1328_CR33) 2018; 9
I Malanchi (1328_CR82) 2011; 481
AM Krebs (1328_CR50) 2017; 19
KJ Cheung (1328_CR70) 2016; 113
Y Jiang (1328_CR92) 2020; 468
IC Macaulay (1328_CR132) 2015; 12
F Castro-Giner (1328_CR114) 2020; 12
L Melchor (1328_CR3) 2014; 233
1328_CR47
OH Ocana (1328_CR101) 2012; 22
References_xml – volume: 38
  start-page: 7113
  year: 2019
  end-page: 7132
  ident: CR108
  article-title: Inducible formation of leader cells driven by CD44 switching gives rise to collective invasion and metastases in luminal breast carcinomas
  publication-title: Oncogene
  doi: 10.1038/s41388-019-0899-y
– volume: 75
  start-page: 2749
  year: 2015
  end-page: 2759
  ident: CR118
  article-title: Tracking and functional characterization of epithelial-mesenchymal transition and mesenchymal tumor cells during prostate cancer metastasis
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-14-3476
– volume: 11
  start-page: 2081
  year: 2016
  end-page: 2103
  ident: CR133
  article-title: Separation and parallel sequencing of the genomes and transcriptomes of single cells using G&T-seq
  publication-title: Nat. Protoc.
  doi: 10.1038/nprot.2016.138
– volume: 514
  start-page: 54
  year: 2014
  end-page: 58
  ident: CR77
  article-title: Non-cell-autonomous driving of tumour growth supports sub-clonal heterogeneity
  publication-title: Nature
  doi: 10.1038/nature13556
– volume: 527
  start-page: 525
  year: 2015
  end-page: 530
  ident: CR51
  article-title: Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer
  publication-title: Nature
  doi: 10.1038/nature16064
– volume: 146
  start-page: 148
  year: 2011
  end-page: 163
  ident: CR78
  article-title: Biomechanical remodeling of the microenvironment by stromal caveolin-1 favors tumor invasion and metastasis
  publication-title: Cell
  doi: 10.1016/j.cell.2011.05.040
– volume: 155
  start-page: 1639
  year: 2013
  end-page: 1651
  ident: CR71
  article-title: Collective invasion in breast cancer requires a conserved basal epithelial program
  publication-title: Cell
  doi: 10.1016/j.cell.2013.11.029
– volume: 481
  start-page: 85
  year: 2011
  end-page: 89
  ident: CR82
  article-title: Interactions between cancer stem cells and their niche govern metastatic colonization
  publication-title: Nature
  doi: 10.1038/nature10694
– volume: 19
  start-page: 274
  year: 2013
  end-page: 275
  ident: CR138
  article-title: Metastasis awakening: the challenges of targeting minimal residual cancer
  publication-title: Nat. Med.
  doi: 10.1038/nm.3121
– volume: 5
  start-page: 66
  year: 2019
  ident: CR1
  article-title: Breast cancer
  publication-title: Nat. Rev. Dis. Primers
  doi: 10.1038/s41572-019-0111-2
– volume: 525
  start-page: 256
  year: 2015
  end-page: 260
  ident: CR57
  article-title: Distinct EMT programs control normal mammary stem cells and tumour-initiating cells
  publication-title: Nature
  doi: 10.1038/nature14897
– volume: 92
  start-page: 1342
  year: 2012
  end-page: 1357
  ident: CR130
  article-title: Evaluating tumor heterogeneity in immunohistochemistry-stained breast cancer tissue
  publication-title: Lab. Investig.
  doi: 10.1038/labinvest.2012.91
– volume: 3
  start-page: 27
  year: 2013
  end-page: 34
  ident: CR9
  article-title: The genomic landscape of breast cancer as a therapeutic roadmap
  publication-title: Cancer Discov.
  doi: 10.1158/2159-8290.CD-12-0462
– volume: 490
  start-page: 61
  year: 2012
  end-page: 70
  ident: CR22
  article-title: Comprehensive molecular portraits of human breast tumours
  publication-title: Nature
  doi: 10.1038/nature11412
– volume: 14
  start-page: 430
  year: 2014
  end-page: 439
  ident: CR94
  article-title: Hypoxia and the extracellular matrix: drivers of tumour metastasis
  publication-title: Nat. Rev. Cancer
  doi: 10.1038/nrc3726
– volume: 10
  start-page: 1096
  year: 2013
  end-page: 1098
  ident: CR134
  article-title: Smart-seq2 for sensitive full-length transcriptome profiling in single cells
  publication-title: Nat. Methods
  doi: 10.1038/nmeth.2639
– volume: 501
  start-page: 355
  year: 2013
  end-page: 364
  ident: CR11
  article-title: Tumour heterogeneity in the clinic
  publication-title: Nature
  doi: 10.1038/nature12627
– volume: 144
  start-page: 646
  year: 2011
  end-page: 674
  ident: CR141
  article-title: Hallmarks of cancer: the next generation
  publication-title: Cell
  doi: 10.1016/j.cell.2011.02.013
– ident: CR129
– volume: 436
  start-page: 518
  year: 2005
  end-page: 524
  ident: CR96
  article-title: Genes that mediate breast cancer metastasis to lung
  publication-title: Nature
  doi: 10.1038/nature03799
– volume: 9
  year: 2018
  ident: CR125
  article-title: Genetic dissection of the miR-200-Zeb1 axis reveals its importance in tumor differentiation and invasion
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-018-07130-z
– volume: 172
  start-page: 205
  year: 2018
  end-page: 217 e212
  ident: CR38
  article-title: Multiclonal invasion in breast tumors identified by topographic single cell sequencing
  publication-title: Cell
  doi: 10.1016/j.cell.2017.12.007
– volume: 547
  start-page: E1
  year: 2017
  end-page: E3
  ident: CR128
  article-title: Upholding a role for EMT in breast cancer metastasis
  publication-title: Nature
  doi: 10.1038/nature22816
– volume: 17
  start-page: 260
  year: 2015
  end-page: 271
  ident: CR12
  article-title: Therapeutic implications of cellular heterogeneity and plasticity in breast cancer
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2015.08.014
– volume: 508
  start-page: 113
  year: 2014
  end-page: 117
  ident: CR66
  article-title: Tumour cell heterogeneity maintained by cooperating subclones in Wnt-driven mammary cancers
  publication-title: Nature
  doi: 10.1038/nature13187
– volume: 15
  year: 2015
  ident: CR110
  article-title: Variable expression levels of keratin and vimentin reveal differential EMT status of circulating tumor cells and correlation with clinical characteristics and outcome of patients with metastatic breast cancer
  publication-title: BMC Cancer
  doi: 10.1186/s12885-015-1386-7
– volume: 12
  start-page: 323
  year: 2012
  end-page: 334
  ident: CR14
  article-title: Intra-tumour heterogeneity: a looking glass for cancer?
  publication-title: Nat. Rev. Cancer
  doi: 10.1038/nrc3261
– volume: 21
  start-page: 846
  year: 2015
  end-page: 853
  ident: CR16
  article-title: Toward understanding and exploiting tumor heterogeneity
  publication-title: Nat. Med.
  doi: 10.1038/nm.3915
– volume: 18
  start-page: 211
  year: 2018
  end-page: 223
  ident: CR36
  article-title: Genetic insights into the morass of metastatic heterogeneity
  publication-title: Nat. Rev. Cancer
  doi: 10.1038/nrc.2017.126
– volume: 22
  start-page: 709
  year: 2012
  end-page: 724
  ident: CR101
  article-title: Metastatic colonization requires the repression of the epithelial-mesenchymal transition inducer Prrx1
  publication-title: Cancer Cell
  doi: 10.1016/j.ccr.2012.10.012
– volume: 15
  start-page: 473
  year: 2015
  end-page: 483
  ident: CR76
  article-title: Tumorigenesis: it takes a village
  publication-title: Nat. Rev. Cancer
  doi: 10.1038/nrc3971
– volume: 525
  start-page: 119
  year: 2015
  end-page: 123
  ident: CR63
  article-title: Reactivation of multipotency by oncogenic PIK3CA induces breast tumour heterogeneity
  publication-title: Nature
  doi: 10.1038/nature14665
– volume: 114
  start-page: 11494
  year: 2017
  end-page: 11499
  ident: CR126
  article-title: Breast tumor cell-specific knockout of Twist1 inhibits cancer cell plasticity, dissemination, and lung metastasis in mice
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1618091114
– volume: 35
  start-page: 17
  year: 2019
  end-page: 32 e16
  ident: CR54
  article-title: Gain fat-lose metastasis: converting invasive breast cancer cells into adipocytes inhibits cancer metastasis
  publication-title: Cancer Cell
  doi: 10.1016/j.ccell.2018.12.002
– volume: 486
  start-page: 346
  year: 2012
  end-page: 352
  ident: CR20
  article-title: The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups
  publication-title: Nature
  doi: 10.1038/nature10983
– volume: 481
  start-page: 306
  year: 2012
  end-page: 313
  ident: CR25
  article-title: Clonal evolution in cancer
  publication-title: Nature
  doi: 10.1038/nature10762
– volume: 566
  start-page: 553
  year: 2019
  end-page: 557
  ident: CR90
  article-title: Neutrophils escort circulating tumour cells to enable cell cycle progression
  publication-title: Nature
  doi: 10.1038/s41586-019-0915-y
– volume: 556
  start-page: 463
  year: 2018
  end-page: 468
  ident: CR48
  article-title: Identification of the tumour transition states occurring during EMT
  publication-title: Nature
  doi: 10.1038/s41586-018-0040-3
– volume: 11
  start-page: 1487
  year: 2009
  end-page: 1495
  ident: CR56
  article-title: The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs
  publication-title: Nat. Cell Biol.
  doi: 10.1038/ncb1998
– volume: 486
  start-page: 405
  year: 2012
  end-page: 409
  ident: CR24
  article-title: Sequence analysis of mutations and translocations across breast cancer subtypes
  publication-title: Nature
  doi: 10.1038/nature11154
– ident: CR47
– volume: 468
  start-page: 72
  year: 2020
  end-page: 81
  ident: CR92
  article-title: Communication between EMT and PD-L1 signaling: new insights into tumor immune evasion
  publication-title: Cancer Lett.
  doi: 10.1016/j.canlet.2019.10.013
– volume: 5
  start-page: 5
  year: 2011
  end-page: 23
  ident: CR8
  article-title: Deconstructing the molecular portraits of breast cancer
  publication-title: Mol. Oncol.
  doi: 10.1016/j.molonc.2010.11.003
– volume: 19
  start-page: 110
  year: 2019
  end-page: 117
  ident: CR72
  article-title: Cooperation among cancer cells: applying game theory to cancer
  publication-title: Nat. Rev. Cancer
  doi: 10.1038/s41568-018-0083-7
– volume: 10
  year: 2019
  ident: CR34
  article-title: Barcoding reveals complex clonal behavior in patient-derived xenografts of metastatic triple negative breast cancer
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-019-08595-2
– volume: 16
  year: 2014
  ident: CR60
  article-title: Sequencing of breast cancer stem cell populations indicates a dynamic conversion between differentiation states in vivo
  publication-title: Breast Cancer Res.
  doi: 10.1186/bcr3687
– volume: 415
  start-page: 530
  year: 2002
  end-page: 536
  ident: CR17
  article-title: Gene expression profiling predicts clinical outcome of breast cancer
  publication-title: Nature
  doi: 10.1038/415530a
– volume: 12
  year: 2010
  ident: CR7
  article-title: Phenotypic and molecular characterization of the claudin-low intrinsic subtype of breast cancer
  publication-title: Breast Cancer Res.
  doi: 10.1186/bcr2635
– volume: 166
  start-page: 21
  year: 2016
  end-page: 45
  ident: CR45
  article-title: Emt: 2016
  publication-title: Cell
  doi: 10.1016/j.cell.2016.06.028
– volume: 139
  start-page: 1315
  year: 2009
  end-page: 1326
  ident: CR68
  article-title: Tumor self-seeding by circulating cancer cells
  publication-title: Cell
  doi: 10.1016/j.cell.2009.11.025
– volume: 24
  start-page: 65
  year: 2019
  end-page: 78
  ident: CR42
  article-title: Phenotypic plasticity: driver of cancer initiation, progression, and therapy resistance
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2018.11.011
– volume: 526
  start-page: 131
  year: 2015
  end-page: 135
  ident: CR53
  article-title: Single-cell analysis reveals a stem-cell program in human metastatic breast cancer cells
  publication-title: Nature
  doi: 10.1038/nature15260
– volume: 149
  start-page: 979
  year: 2012
  end-page: 993
  ident: CR29
  article-title: Mutational processes molding the genomes of 21 breast cancers
  publication-title: Cell
  doi: 10.1016/j.cell.2012.04.024
– volume: 472
  start-page: 90
  year: 2011
  end-page: 94
  ident: CR18
  article-title: Tumour evolution inferred by single-cell sequencing
  publication-title: Nature
  doi: 10.1038/nature09807
– volume: 45
  start-page: 696
  year: 2018
  end-page: 711 e698
  ident: CR121
  article-title: Regulation of epithelial plasticity determines metastatic organotropism in pancreatic cancer
  publication-title: Dev. Cell
  doi: 10.1016/j.devcel.2018.05.025
– volume: 158
  start-page: 1110
  year: 2014
  end-page: 1122
  ident: CR99
  article-title: Circulating tumor cell clusters are oligoclonal precursors of breast cancer metastasis
  publication-title: Cell
  doi: 10.1016/j.cell.2014.07.013
– volume: 52
  start-page: 701
  year: 2020
  end-page: 708
  ident: CR97
  article-title: Multi-cancer analysis of clonality and the timing of systemic spread in paired primary tumors and metastases
  publication-title: Nat. Genet.
  doi: 10.1038/s41588-020-0628-z
– volume: 133
  start-page: 704
  year: 2008
  end-page: 715
  ident: CR55
  article-title: The epithelial-mesenchymal transition generates cells with properties of stem cells
  publication-title: Cell
  doi: 10.1016/j.cell.2008.03.027
– volume: 21
  start-page: 102
  year: 2019
  end-page: 112
  ident: CR127
  article-title: Non-redundant functions of EMT transcription factors
  publication-title: Nat. Cell Biol.
  doi: 10.1038/s41556-018-0196-y
– volume: 508
  start-page: 52
  year: 2014
  end-page: 53
  ident: CR67
  article-title: Cancer: clonal cooperation
  publication-title: Nature
  doi: 10.1038/508052a
– volume: 71
  start-page: 6857
  year: 2011
  end-page: 6866
  ident: CR80
  article-title: Breast cancer subtype-specific interactions with the microenvironment dictate mechanisms of invasion
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-11-1818
– volume: 154
  start-page: 61
  year: 2013
  end-page: 74
  ident: CR58
  article-title: Poised chromatin at the ZEB1 promoter enables breast cancer cell plasticity and enhances tumorigenicity
  publication-title: Cell
  doi: 10.1016/j.cell.2013.06.005
– volume: 15
  start-page: 73
  year: 2015
  end-page: 86
  ident: CR65
  article-title: Immune cell promotion of metastasis
  publication-title: Nat. Rev. Immunol.
  doi: 10.1038/nri3789
– volume: 26
  start-page: 569
  year: 2020
  end-page: 578 e567
  ident: CR119
  article-title: Plasticity of Lgr5-negative cancer cells drives metastasis in colorectal cancer
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2020.02.008
– volume: 236
  start-page: 457
  year: 2015
  end-page: 466
  ident: CR41
  article-title: Uncovering the genomic heterogeneity of multifocal breast cancer
  publication-title: J. Pathol.
  doi: 10.1002/path.4540
– volume: 43
  start-page: 46
  year: 2016
  end-page: 54
  ident: CR44
  article-title: Cellular plasticity: 1712 to the present day
  publication-title: Curr. Opin. Cell Biol.
  doi: 10.1016/j.ceb.2016.07.005
– volume: 527
  start-page: 472
  year: 2015
  end-page: 476
  ident: CR123
  article-title: Epithelial-to-mesenchymal transition is not required for lung metastasis but contributes to chemoresistance
  publication-title: Nature
  doi: 10.1038/nature15748
– volume: 461
  start-page: 809
  year: 2009
  end-page: 813
  ident: CR19
  article-title: Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution
  publication-title: Nature
  doi: 10.1038/nature08489
– volume: 21
  start-page: 797
  year: 2019
  end-page: 798
  ident: CR89
  article-title: Subclonal cooperation rewrites metastasis
  publication-title: Nat. Cell Biol.
  doi: 10.1038/s41556-019-0353-y
– volume: 18
  start-page: 128
  year: 2018
  end-page: 134
  ident: CR52
  article-title: EMT in cancer
  publication-title: Nat. Rev. Cancer
  doi: 10.1038/nrc.2017.118
– volume: 68
  start-page: 937
  year: 2008
  end-page: 945
  ident: CR64
  article-title: Direct evidence for epithelial-mesenchymal transitions in breast cancer
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-07-2148
– volume: 486
  start-page: 395
  year: 2012
  end-page: 399
  ident: CR21
  article-title: The clonal and mutational evolution spectrum of primary triple-negative breast cancers
  publication-title: Nature
  doi: 10.1038/nature10933
– volume: 149
  start-page: 994
  year: 2012
  end-page: 1007
  ident: CR30
  article-title: The life history of 21 breast cancers
  publication-title: Cell
  doi: 10.1016/j.cell.2012.04.023
– volume: 21
  start-page: 751
  year: 2015
  end-page: 759
  ident: CR40
  article-title: Subclonal diversification of primary breast cancer revealed by multiregion sequencing
  publication-title: Nat. Med.
  doi: 10.1038/nm.3886
– volume: 22
  start-page: 725
  year: 2012
  end-page: 736
  ident: CR102
  article-title: Spatiotemporal regulation of epithelial-mesenchymal transition is essential for squamous cell carcinoma metastasis
  publication-title: Cancer Cell
  doi: 10.1016/j.ccr.2012.09.022
– volume: 467
  start-page: 1114
  year: 2010
  end-page: 1117
  ident: CR28
  article-title: Distant metastasis occurs late during the genetic evolution of pancreatic cancer
  publication-title: Nature
  doi: 10.1038/nature09515
– volume: 9
  year: 2018
  ident: CR33
  article-title: High-resolution clonal mapping of multi-organ metastasis in triple negative breast cancer
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-018-07406-4
– volume: 29
  start-page: 212
  year: 2019
  end-page: 226
  ident: CR46
  article-title: EMT transition states during tumor progression and metastasis
  publication-title: Trends Cell Biol.
  doi: 10.1016/j.tcb.2018.12.001
– volume: 74
  start-page: 6330
  year: 2014
  end-page: 6340
  ident: CR115
  article-title: Transient SNAIL1 expression is necessary for metastatic competence in breast cancer
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-14-0923
– volume: 10
  year: 2019
  ident: CR104
  article-title: Collective cell migration and metastases induced by an epithelial-to-mesenchymal transition in Drosophila intestinal tumors
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-019-10269-y
– volume: 525
  start-page: 114
  year: 2015
  end-page: 118
  ident: CR62
  article-title: PIK3CA(H1047R) induces multipotency and multi-lineage mammary tumours
  publication-title: Nature
  doi: 10.1038/nature14669
– volume: 29
  start-page: 2565
  year: 2019
  end-page: 2569 e2563
  ident: CR113
  article-title: Fsp1-mediated lineage tracing fails to detect the majority of disseminating cells undergoing EMT
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2019.10.107
– volume: 13
  start-page: 2456
  year: 2015
  end-page: 2469
  ident: CR117
  article-title: Mesenchymal cancer cell-stroma crosstalk promotes niche activation, epithelial reversion, and metastatic colonization
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2015.11.025
– volume: 9
  year: 2018
  ident: CR86
  article-title: Macrophages orchestrate breast cancer early dissemination and metastasis
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-017-02481-5
– volume: 14
  year: 2012
  ident: CR81
  article-title: Lack of transforming growth factor-beta signaling promotes collective cancer cell invasion through tumor-stromal crosstalk
  publication-title: Breast Cancer Res.
  doi: 10.1186/bcr3217
– volume: 21
  start-page: 879
  year: 2019
  end-page: 888
  ident: CR88
  article-title: Subclonal cooperation drives metastasis by modulating local and systemic immune microenvironments
  publication-title: Nat. Cell Biol.
  doi: 10.1038/s41556-019-0346-x
– volume: 147
  start-page: 992
  year: 2011
  end-page: 1009
  ident: CR103
  article-title: Cancer invasion and the microenvironment: plasticity and reciprocity
  publication-title: Cell
  doi: 10.1016/j.cell.2011.11.016
– volume: 30
  start-page: 365
  year: 2016
  ident: CR85
  article-title: The multifaceted role of perivascular macrophages in tumors
  publication-title: Cancer Cell
  doi: 10.1016/j.ccell.2016.07.009
– volume: 3
  start-page: 537
  year: 2003
  end-page: 549
  ident: CR95
  article-title: A multigenic program mediating breast cancer metastasis to bone
  publication-title: Cancer Cell
  doi: 10.1016/S1535-6108(03)00132-6
– volume: 34
  start-page: 5309
  year: 2015
  end-page: 5316
  ident: CR4
  article-title: The origin of breast tumor heterogeneity
  publication-title: Oncogene
  doi: 10.1038/onc.2014.475
– volume: 8
  start-page: 98
  year: 1889
  end-page: 101
  ident: CR136
  article-title: The distribution of secondary growths in cancer of the breast.
  publication-title: Cancer Metastasis Rev.
– volume: 103
  start-page: 2892
  year: 2004
  end-page: 2899
  ident: CR43
  article-title: Environmental guidance of normal and tumor cell plasticity: epithelial mesenchymal transitions as a paradigm
  publication-title: Blood
  doi: 10.1182/blood-2003-08-2807
– volume: 19
  start-page: 518
  year: 2017
  end-page: 529
  ident: CR50
  article-title: The EMT-activator Zeb1 is a key factor for cell plasticity and promotes metastasis in pancreatic cancer
  publication-title: Nat. Cell Biol.
  doi: 10.1038/ncb3513
– volume: 19
  start-page: 405
  year: 2019
  end-page: 414
  ident: CR140
  article-title: Ferroptosis at the crossroads of cancer-acquired drug resistance and immune evasion
  publication-title: Nat. Rev. Cancer
  doi: 10.1038/s41568-019-0149-1
– volume: 35
  start-page: 618
  year: 2019
  end-page: 632 e616
  ident: CR49
  article-title: Intraclonal plasticity in mammary tumors revealed through large-scale single-cell resolution 3D imaging
  publication-title: Cancer Cell
  doi: 10.1016/j.ccell.2019.02.010
– volume: 4
  start-page: 540
  year: 2004
  end-page: 550
  ident: CR83
  article-title: Cancer and the chemokine network
  publication-title: Nat. Rev. Cancer
  doi: 10.1038/nrc1388
– volume: 233
  start-page: 124
  year: 2014
  end-page: 137
  ident: CR3
  article-title: Identification of cellular and genetic drivers of breast cancer heterogeneity in genetically engineered mouse tumour models
  publication-title: J. Pathol.
  doi: 10.1002/path.4345
– volume: 8
  start-page: 444
  year: 2007
  end-page: 448
  ident: CR109
  article-title: Active versus passive mechanisms in metastasis: do cancer cells crawl into vessels, or are they pushed?
  publication-title: Lancet Oncol.
  doi: 10.1016/S1470-2045(07)70140-7
– volume: 146
  start-page: 633
  year: 2011
  end-page: 644
  ident: CR59
  article-title: Stochastic state transitions give rise to phenotypic equilibrium in populations of cancer cells
  publication-title: Cell
  doi: 10.1016/j.cell.2011.07.026
– volume: 567
  start-page: 540
  year: 2019
  end-page: 544
  ident: CR98
  article-title: Glucocorticoids promote breast cancer metastasis
  publication-title: Nature
  doi: 10.1038/s41586-019-1019-4
– ident: CR105
– volume: 20
  start-page: 25
  year: 2020
  end-page: 39
  ident: CR93
  article-title: Tumour-intrinsic resistance to immune checkpoint blockade
  publication-title: Nat. Rev. Immunol.
  doi: 10.1038/s41577-019-0218-4
– ident: CR122
– volume: 520
  start-page: 358
  year: 2015
  end-page: 362
  ident: CR35
  article-title: A model of breast cancer heterogeneity reveals vascular mimicry as a driver of metastasis
  publication-title: Nature
  doi: 10.1038/nature14403
– volume: 12
  start-page: 519
  year: 2015
  end-page: 522
  ident: CR132
  article-title: G&T-seq: parallel sequencing of single-cell genomes and transcriptomes
  publication-title: Nat. Methods
  doi: 10.1038/nmeth.3370
– volume: 187
  start-page: 2152
  year: 2017
  end-page: 2162
  ident: CR23
  article-title: Breast cancer molecular stratification: from intrinsic subtypes to integrative clusters
  publication-title: Am. J. Pathol.
  doi: 10.1016/j.ajpath.2017.04.022
– volume: 216
  start-page: 1016
  year: 2019
  end-page: 1026
  ident: CR124
  article-title: Context-dependent EMT programs in cancer metastasis
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.20181827
– volume: 113
  start-page: E854
  year: 2016
  end-page: E863
  ident: CR70
  article-title: Polyclonal breast cancer metastases arise from collective dissemination of keratin 14-expressing tumor cell clusters
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1508541113
– volume: 194
  start-page: 23
  year: 1976
  end-page: 28
  ident: CR26
  article-title: The clonal evolution of tumor cell populations
  publication-title: Science
  doi: 10.1126/science.959840
– volume: 23
  start-page: 1239
  year: 2018
  end-page: 1248
  ident: CR87
  article-title: A unidirectional transition from migratory to perivascular macrophage is required for tumor cell intravasation
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2018.04.007
– volume: 406
  start-page: 747
  year: 2000
  end-page: 752
  ident: CR6
  article-title: Molecular portraits of human breast tumours
  publication-title: Nature
  doi: 10.1038/35021093
– volume: 168
  start-page: 613
  year: 2017
  end-page: 628
  ident: CR15
  article-title: Clonal heterogeneity and tumor evolution: past, present, and the future
  publication-title: Cell
  doi: 10.1016/j.cell.2017.01.018
– volume: 12
  year: 2020
  ident: CR114
  article-title: Tracking cancer progression: from circulating tumor cells to metastasis
  publication-title: Genome Med.
  doi: 10.1186/s13073-020-00728-3
– volume: 72
  start-page: 4875
  year: 2012
  end-page: 4882
  ident: CR39
  article-title: Intratumor heterogeneity: evolution through space and time
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-12-2217
– volume: 24
  start-page: 3237
  year: 2018
  end-page: 3250
  ident: CR61
  article-title: Regulation of cellular heterogeneity and rates of symmetric and asymmetric divisions in triple-negative breast cancer
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2018.08.053
– volume: 25
  start-page: 605
  year: 2014
  end-page: 620
  ident: CR84
  article-title: A positive feedback loop between mesenchymal-like cancer cells and macrophages is essential to breast cancer metastasis
  publication-title: Cancer Cell
  doi: 10.1016/j.ccr.2014.03.021
– volume: 20
  start-page: 1349
  year: 2018
  end-page: 1360
  ident: CR13
  article-title: Tumour heterogeneity and metastasis at single-cell resolution
  publication-title: Nat. Cell. Biol.
  doi: 10.1038/s41556-018-0236-7
– volume: 9
  start-page: 239
  year: 2009
  end-page: 252
  ident: CR73
  article-title: Microenvironmental regulation of metastasis
  publication-title: Nat. Rev. Cancer
  doi: 10.1038/nrc2618
– volume: 501
  start-page: 346
  year: 2013
  end-page: 354
  ident: CR74
  article-title: Influence of tumour micro-environment heterogeneity on therapeutic response
  publication-title: Nature
  doi: 10.1038/nature12626
– volume: 19
  start-page: 1423
  year: 2013
  end-page: 1437
  ident: CR75
  article-title: Microenvironmental regulation of tumor progression and metastasis
  publication-title: Nat. Med.
  doi: 10.1038/nm.3394
– volume: 176
  start-page: 98
  year: 2019
  end-page: 112 e114
  ident: CR100
  article-title: Circulating tumor cell clustering shapes DNA methylation to enable metastasis seeding
  publication-title: Cell
  doi: 10.1016/j.cell.2018.11.046
– volume: 28
  start-page: 1143
  year: 2014
  end-page: 1158
  ident: CR5
  article-title: Mammary stem cells and the differentiation hierarchy: current status and perspectives
  publication-title: Genes Dev.
  doi: 10.1101/gad.242511.114
– volume: 8
  start-page: 381
  year: 2018
  ident: CR120
  article-title: EMT and stemness in tumor dormancy and outgrowth: are they intertwined processes?
  publication-title: Front. Oncol.
  doi: 10.3389/fonc.2018.00381
– volume: 467
  start-page: 1109
  year: 2010
  end-page: 1113
  ident: CR27
  article-title: The patterns and dynamics of genomic instability in metastatic pancreatic cancer
  publication-title: Nature
  doi: 10.1038/nature09460
– volume: 520
  start-page: 353
  year: 2015
  end-page: 357
  ident: CR69
  article-title: The evolutionary history of lethal metastatic prostate cancer
  publication-title: Nature
  doi: 10.1038/nature14347
– volume: 45
  start-page: 681
  year: 2018
  end-page: 695 e684
  ident: CR107
  article-title: EMT subtype influences epithelial plasticity and mode of cell migration
  publication-title: Dev. Cell
  doi: 10.1016/j.devcel.2018.05.027
– volume: 60
  start-page: 537
  year: 2015
  end-page: 546
  ident: CR2
  article-title: Breast tumor heterogeneity: source of fitness, hurdle for therapy
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2015.10.031
– volume: 5
  year: 2014
  ident: CR31
  article-title: DNA barcoding reveals diverse growth kinetics of human breast tumour subclones in serially passaged xenografts
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms6871
– volume: 99
  start-page: 31
  year: 1982
  end-page: 68
  ident: CR10
  article-title: How does the extracellular matrix direct gene expression?
  publication-title: J. Theor. Biol.
  doi: 10.1016/0022-5193(82)90388-5
– volume: 12
  start-page: 566
  year: 2017
  end-page: 580
  ident: CR131
  article-title: Spatial transcriptomic analysis of cryosectioned tissue samples with Geo-seq
  publication-title: Nat. Protoc.
  doi: 10.1038/nprot.2017.003
– volume: 14
  start-page: 2281
  year: 2016
  end-page: 2288
  ident: CR112
  article-title: Plasticity between epithelial and mesenchymal states unlinks EMT from metastasis-enhancing stem cell capacity
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2016.02.034
– volume: 9
  start-page: 1392
  year: 2007
  end-page: 1400
  ident: CR79
  article-title: Fibroblast-led collective invasion of carcinoma cells with differing roles for RhoGTPases in leading and following cells
  publication-title: Nat. Cell Biol.
  doi: 10.1038/ncb1658
– volume: 339
  start-page: 580
  year: 2013
  end-page: 584
  ident: CR111
  article-title: Circulating breast tumor cells exhibit dynamic changes in epithelial and mesenchymal composition
  publication-title: Science
  doi: 10.1126/science.1228522
– volume: 75
  start-page: 3925
  year: 2015
  end-page: 3935
  ident: CR106
  article-title: DeltaNp63alpha promotes breast cancer cell motility through the selective activation of components of the epithelial-to-mesenchymal transition program
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-14-3363
– volume: 147
  start-page: 275
  year: 2011
  end-page: 292
  ident: CR137
  article-title: Tumor metastasis: molecular insights and evolving paradigms
  publication-title: Cell
  doi: 10.1016/j.cell.2011.09.024
– volume: 5
  start-page: 1228
  year: 2013
  end-page: 1242
  ident: CR116
  article-title: TGF-beta-Id1 signaling opposes Twist1 and promotes metastatic colonization via a mesenchymal-to-epithelial transition
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2013.11.014
– volume: 19
  start-page: 667
  year: 2019
  end-page: 685
  ident: CR139
  article-title: The pro-tumorigenic host response to cancer therapies
  publication-title: Nat. Rev. Cancer
  doi: 10.1038/s41568-019-0209-6
– volume: 528
  start-page: 267
  year: 2015
  end-page: 271
  ident: CR32
  article-title: Barcoding reveals complex clonal dynamics of de novo transformed human mammary cells
  publication-title: Nature
  doi: 10.1038/nature15742
– volume: 501
  start-page: 365
  year: 2013
  end-page: 372
  ident: CR37
  article-title: Selection and adaptation during metastatic cancer progression
  publication-title: Nature
  doi: 10.1038/nature12628
– volume: 9
  start-page: 171
  year: 2014
  end-page: 181
  ident: CR135
  article-title: Full-length RNA-seq from single cells using Smart-seq2
  publication-title: Nat. Protoc.
  doi: 10.1038/nprot.2014.006
– volume: 14
  start-page: 155
  year: 2017
  end-page: 167
  ident: CR91
  article-title: Circulating and disseminated tumour cells—mechanisms of immune surveillance and escape
  publication-title: Nat. Rev. Clin. Oncol.
  doi: 10.1038/nrclinonc.2016.144
– volume: 28
  start-page: 1143
  year: 2014
  ident: 1328_CR5
  publication-title: Genes Dev.
  doi: 10.1101/gad.242511.114
– volume: 508
  start-page: 52
  year: 2014
  ident: 1328_CR67
  publication-title: Nature
  doi: 10.1038/508052a
– volume: 501
  start-page: 355
  year: 2013
  ident: 1328_CR11
  publication-title: Nature
  doi: 10.1038/nature12627
– volume: 19
  start-page: 110
  year: 2019
  ident: 1328_CR72
  publication-title: Nat. Rev. Cancer
  doi: 10.1038/s41568-018-0083-7
– volume: 556
  start-page: 463
  year: 2018
  ident: 1328_CR48
  publication-title: Nature
  doi: 10.1038/s41586-018-0040-3
– volume: 9
  year: 2018
  ident: 1328_CR33
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-018-07406-4
– volume: 35
  start-page: 17
  year: 2019
  ident: 1328_CR54
  publication-title: Cancer Cell
  doi: 10.1016/j.ccell.2018.12.002
– volume: 4
  start-page: 540
  year: 2004
  ident: 1328_CR83
  publication-title: Nat. Rev. Cancer
  doi: 10.1038/nrc1388
– volume: 99
  start-page: 31
  year: 1982
  ident: 1328_CR10
  publication-title: J. Theor. Biol.
  doi: 10.1016/0022-5193(82)90388-5
– volume: 520
  start-page: 358
  year: 2015
  ident: 1328_CR35
  publication-title: Nature
  doi: 10.1038/nature14403
– ident: 1328_CR122
  doi: 10.15252/emmm.201809085
– volume: 35
  start-page: 618
  year: 2019
  ident: 1328_CR49
  publication-title: Cancer Cell
  doi: 10.1016/j.ccell.2019.02.010
– volume: 481
  start-page: 85
  year: 2011
  ident: 1328_CR82
  publication-title: Nature
  doi: 10.1038/nature10694
– volume: 14
  start-page: 2281
  year: 2016
  ident: 1328_CR112
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2016.02.034
– volume: 29
  start-page: 2565
  year: 2019
  ident: 1328_CR113
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2019.10.107
– volume: 149
  start-page: 979
  year: 2012
  ident: 1328_CR29
  publication-title: Cell
  doi: 10.1016/j.cell.2012.04.024
– volume: 15
  start-page: 73
  year: 2015
  ident: 1328_CR65
  publication-title: Nat. Rev. Immunol.
  doi: 10.1038/nri3789
– volume: 45
  start-page: 696
  year: 2018
  ident: 1328_CR121
  publication-title: Dev. Cell
  doi: 10.1016/j.devcel.2018.05.025
– volume: 9
  year: 2018
  ident: 1328_CR125
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-018-07130-z
– volume: 19
  start-page: 405
  year: 2019
  ident: 1328_CR140
  publication-title: Nat. Rev. Cancer
  doi: 10.1038/s41568-019-0149-1
– volume: 24
  start-page: 3237
  year: 2018
  ident: 1328_CR61
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2018.08.053
– volume: 15
  year: 2015
  ident: 1328_CR110
  publication-title: BMC Cancer
  doi: 10.1186/s12885-015-1386-7
– volume: 103
  start-page: 2892
  year: 2004
  ident: 1328_CR43
  publication-title: Blood
  doi: 10.1182/blood-2003-08-2807
– volume: 194
  start-page: 23
  year: 1976
  ident: 1328_CR26
  publication-title: Science
  doi: 10.1126/science.959840
– volume: 514
  start-page: 54
  year: 2014
  ident: 1328_CR77
  publication-title: Nature
  doi: 10.1038/nature13556
– volume: 14
  start-page: 430
  year: 2014
  ident: 1328_CR94
  publication-title: Nat. Rev. Cancer
  doi: 10.1038/nrc3726
– volume: 18
  start-page: 211
  year: 2018
  ident: 1328_CR36
  publication-title: Nat. Rev. Cancer
  doi: 10.1038/nrc.2017.126
– volume: 19
  start-page: 274
  year: 2013
  ident: 1328_CR138
  publication-title: Nat. Med.
  doi: 10.1038/nm.3121
– volume: 472
  start-page: 90
  year: 2011
  ident: 1328_CR18
  publication-title: Nature
  doi: 10.1038/nature09807
– volume: 526
  start-page: 131
  year: 2015
  ident: 1328_CR53
  publication-title: Nature
  doi: 10.1038/nature15260
– volume: 16
  year: 2014
  ident: 1328_CR60
  publication-title: Breast Cancer Res.
  doi: 10.1186/bcr3687
– volume: 75
  start-page: 2749
  year: 2015
  ident: 1328_CR118
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-14-3476
– volume: 520
  start-page: 353
  year: 2015
  ident: 1328_CR69
  publication-title: Nature
  doi: 10.1038/nature14347
– volume: 525
  start-page: 119
  year: 2015
  ident: 1328_CR63
  publication-title: Nature
  doi: 10.1038/nature14665
– volume: 14
  start-page: 155
  year: 2017
  ident: 1328_CR91
  publication-title: Nat. Rev. Clin. Oncol.
  doi: 10.1038/nrclinonc.2016.144
– volume: 486
  start-page: 395
  year: 2012
  ident: 1328_CR21
  publication-title: Nature
  doi: 10.1038/nature10933
– volume: 154
  start-page: 61
  year: 2013
  ident: 1328_CR58
  publication-title: Cell
  doi: 10.1016/j.cell.2013.06.005
– volume: 72
  start-page: 4875
  year: 2012
  ident: 1328_CR39
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-12-2217
– volume: 9
  start-page: 171
  year: 2014
  ident: 1328_CR135
  publication-title: Nat. Protoc.
  doi: 10.1038/nprot.2014.006
– volume: 527
  start-page: 472
  year: 2015
  ident: 1328_CR123
  publication-title: Nature
  doi: 10.1038/nature15748
– volume: 486
  start-page: 405
  year: 2012
  ident: 1328_CR24
  publication-title: Nature
  doi: 10.1038/nature11154
– volume: 22
  start-page: 709
  year: 2012
  ident: 1328_CR101
  publication-title: Cancer Cell
  doi: 10.1016/j.ccr.2012.10.012
– volume: 21
  start-page: 846
  year: 2015
  ident: 1328_CR16
  publication-title: Nat. Med.
  doi: 10.1038/nm.3915
– volume: 501
  start-page: 346
  year: 2013
  ident: 1328_CR74
  publication-title: Nature
  doi: 10.1038/nature12626
– volume: 144
  start-page: 646
  year: 2011
  ident: 1328_CR141
  publication-title: Cell
  doi: 10.1016/j.cell.2011.02.013
– volume: 158
  start-page: 1110
  year: 2014
  ident: 1328_CR99
  publication-title: Cell
  doi: 10.1016/j.cell.2014.07.013
– volume: 15
  start-page: 473
  year: 2015
  ident: 1328_CR76
  publication-title: Nat. Rev. Cancer
  doi: 10.1038/nrc3971
– volume: 71
  start-page: 6857
  year: 2011
  ident: 1328_CR80
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-11-1818
– volume: 461
  start-page: 809
  year: 2009
  ident: 1328_CR19
  publication-title: Nature
  doi: 10.1038/nature08489
– volume: 75
  start-page: 3925
  year: 2015
  ident: 1328_CR106
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-14-3363
– volume: 166
  start-page: 21
  year: 2016
  ident: 1328_CR45
  publication-title: Cell
  doi: 10.1016/j.cell.2016.06.028
– volume: 415
  start-page: 530
  year: 2002
  ident: 1328_CR17
  publication-title: Nature
  doi: 10.1038/415530a
– volume: 20
  start-page: 1349
  year: 2018
  ident: 1328_CR13
  publication-title: Nat. Cell. Biol.
  doi: 10.1038/s41556-018-0236-7
– volume: 12
  year: 2020
  ident: 1328_CR114
  publication-title: Genome Med.
  doi: 10.1186/s13073-020-00728-3
– volume: 187
  start-page: 2152
  year: 2017
  ident: 1328_CR23
  publication-title: Am. J. Pathol.
  doi: 10.1016/j.ajpath.2017.04.022
– volume: 21
  start-page: 751
  year: 2015
  ident: 1328_CR40
  publication-title: Nat. Med.
  doi: 10.1038/nm.3886
– volume: 10
  start-page: 1096
  year: 2013
  ident: 1328_CR134
  publication-title: Nat. Methods
  doi: 10.1038/nmeth.2639
– volume: 60
  start-page: 537
  year: 2015
  ident: 1328_CR2
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2015.10.031
– volume: 467
  start-page: 1114
  year: 2010
  ident: 1328_CR28
  publication-title: Nature
  doi: 10.1038/nature09515
– volume: 490
  start-page: 61
  year: 2012
  ident: 1328_CR22
  publication-title: Nature
  doi: 10.1038/nature11412
– volume: 146
  start-page: 633
  year: 2011
  ident: 1328_CR59
  publication-title: Cell
  doi: 10.1016/j.cell.2011.07.026
– volume: 216
  start-page: 1016
  year: 2019
  ident: 1328_CR124
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.20181827
– volume: 567
  start-page: 540
  year: 2019
  ident: 1328_CR98
  publication-title: Nature
  doi: 10.1038/s41586-019-1019-4
– volume: 233
  start-page: 124
  year: 2014
  ident: 1328_CR3
  publication-title: J. Pathol.
  doi: 10.1002/path.4345
– volume: 12
  start-page: 519
  year: 2015
  ident: 1328_CR132
  publication-title: Nat. Methods
  doi: 10.1038/nmeth.3370
– volume: 547
  start-page: E1
  year: 2017
  ident: 1328_CR128
  publication-title: Nature
  doi: 10.1038/nature22816
– volume: 29
  start-page: 212
  year: 2019
  ident: 1328_CR46
  publication-title: Trends Cell Biol.
  doi: 10.1016/j.tcb.2018.12.001
– volume: 19
  start-page: 1423
  year: 2013
  ident: 1328_CR75
  publication-title: Nat. Med.
  doi: 10.1038/nm.3394
– volume: 13
  start-page: 2456
  year: 2015
  ident: 1328_CR117
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2015.11.025
– volume: 19
  start-page: 667
  year: 2019
  ident: 1328_CR139
  publication-title: Nat. Rev. Cancer
  doi: 10.1038/s41568-019-0209-6
– volume: 168
  start-page: 613
  year: 2017
  ident: 1328_CR15
  publication-title: Cell
  doi: 10.1016/j.cell.2017.01.018
– volume: 24
  start-page: 65
  year: 2019
  ident: 1328_CR42
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2018.11.011
– volume: 68
  start-page: 937
  year: 2008
  ident: 1328_CR64
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-07-2148
– volume: 113
  start-page: E854
  year: 2016
  ident: 1328_CR70
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1508541113
– volume: 12
  year: 2010
  ident: 1328_CR7
  publication-title: Breast Cancer Res.
  doi: 10.1186/bcr2635
– volume: 236
  start-page: 457
  year: 2015
  ident: 1328_CR41
  publication-title: J. Pathol.
  doi: 10.1002/path.4540
– volume: 8
  start-page: 98
  year: 1889
  ident: 1328_CR136
  publication-title: Cancer Metastasis Rev.
– ident: 1328_CR129
  doi: 10.1038/s41586-019-1526-3
– volume: 34
  start-page: 5309
  year: 2015
  ident: 1328_CR4
  publication-title: Oncogene
  doi: 10.1038/onc.2014.475
– volume: 527
  start-page: 525
  year: 2015
  ident: 1328_CR51
  publication-title: Nature
  doi: 10.1038/nature16064
– volume: 11
  start-page: 1487
  year: 2009
  ident: 1328_CR56
  publication-title: Nat. Cell Biol.
  doi: 10.1038/ncb1998
– volume: 11
  start-page: 2081
  year: 2016
  ident: 1328_CR133
  publication-title: Nat. Protoc.
  doi: 10.1038/nprot.2016.138
– volume: 3
  start-page: 27
  year: 2013
  ident: 1328_CR9
  publication-title: Cancer Discov.
  doi: 10.1158/2159-8290.CD-12-0462
– volume: 10
  year: 2019
  ident: 1328_CR104
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-019-10269-y
– ident: 1328_CR47
  doi: 10.1038/s41580-020-0237-9
– volume: 146
  start-page: 148
  year: 2011
  ident: 1328_CR78
  publication-title: Cell
  doi: 10.1016/j.cell.2011.05.040
– volume: 52
  start-page: 701
  year: 2020
  ident: 1328_CR97
  publication-title: Nat. Genet.
  doi: 10.1038/s41588-020-0628-z
– volume: 19
  start-page: 518
  year: 2017
  ident: 1328_CR50
  publication-title: Nat. Cell Biol.
  doi: 10.1038/ncb3513
– volume: 20
  start-page: 25
  year: 2020
  ident: 1328_CR93
  publication-title: Nat. Rev. Immunol.
  doi: 10.1038/s41577-019-0218-4
– volume: 525
  start-page: 114
  year: 2015
  ident: 1328_CR62
  publication-title: Nature
  doi: 10.1038/nature14669
– volume: 5
  start-page: 5
  year: 2011
  ident: 1328_CR8
  publication-title: Mol. Oncol.
  doi: 10.1016/j.molonc.2010.11.003
– volume: 467
  start-page: 1109
  year: 2010
  ident: 1328_CR27
  publication-title: Nature
  doi: 10.1038/nature09460
– volume: 14
  year: 2012
  ident: 1328_CR81
  publication-title: Breast Cancer Res.
  doi: 10.1186/bcr3217
– volume: 436
  start-page: 518
  year: 2005
  ident: 1328_CR96
  publication-title: Nature
  doi: 10.1038/nature03799
– volume: 18
  start-page: 128
  year: 2018
  ident: 1328_CR52
  publication-title: Nat. Rev. Cancer
  doi: 10.1038/nrc.2017.118
– volume: 9
  start-page: 1392
  year: 2007
  ident: 1328_CR79
  publication-title: Nat. Cell Biol.
  doi: 10.1038/ncb1658
– volume: 468
  start-page: 72
  year: 2020
  ident: 1328_CR92
  publication-title: Cancer Lett.
  doi: 10.1016/j.canlet.2019.10.013
– volume: 481
  start-page: 306
  year: 2012
  ident: 1328_CR25
  publication-title: Nature
  doi: 10.1038/nature10762
– volume: 5
  start-page: 66
  year: 2019
  ident: 1328_CR1
  publication-title: Nat. Rev. Dis. Primers
  doi: 10.1038/s41572-019-0111-2
– volume: 21
  start-page: 797
  year: 2019
  ident: 1328_CR89
  publication-title: Nat. Cell Biol.
  doi: 10.1038/s41556-019-0353-y
– volume: 172
  start-page: 205
  year: 2018
  ident: 1328_CR38
  publication-title: Cell
  doi: 10.1016/j.cell.2017.12.007
– volume: 147
  start-page: 992
  year: 2011
  ident: 1328_CR103
  publication-title: Cell
  doi: 10.1016/j.cell.2011.11.016
– volume: 508
  start-page: 113
  year: 2014
  ident: 1328_CR66
  publication-title: Nature
  doi: 10.1038/nature13187
– volume: 43
  start-page: 46
  year: 2016
  ident: 1328_CR44
  publication-title: Curr. Opin. Cell Biol.
  doi: 10.1016/j.ceb.2016.07.005
– volume: 133
  start-page: 704
  year: 2008
  ident: 1328_CR55
  publication-title: Cell
  doi: 10.1016/j.cell.2008.03.027
– volume: 21
  start-page: 879
  year: 2019
  ident: 1328_CR88
  publication-title: Nat. Cell Biol.
  doi: 10.1038/s41556-019-0346-x
– volume: 92
  start-page: 1342
  year: 2012
  ident: 1328_CR130
  publication-title: Lab. Investig.
  doi: 10.1038/labinvest.2012.91
– volume: 45
  start-page: 681
  year: 2018
  ident: 1328_CR107
  publication-title: Dev. Cell
  doi: 10.1016/j.devcel.2018.05.027
– volume: 38
  start-page: 7113
  year: 2019
  ident: 1328_CR108
  publication-title: Oncogene
  doi: 10.1038/s41388-019-0899-y
– volume: 155
  start-page: 1639
  year: 2013
  ident: 1328_CR71
  publication-title: Cell
  doi: 10.1016/j.cell.2013.11.029
– volume: 525
  start-page: 256
  year: 2015
  ident: 1328_CR57
  publication-title: Nature
  doi: 10.1038/nature14897
– volume: 23
  start-page: 1239
  year: 2018
  ident: 1328_CR87
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2018.04.007
– volume: 17
  start-page: 260
  year: 2015
  ident: 1328_CR12
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2015.08.014
– volume: 26
  start-page: 569
  year: 2020
  ident: 1328_CR119
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2020.02.008
– volume: 147
  start-page: 275
  year: 2011
  ident: 1328_CR137
  publication-title: Cell
  doi: 10.1016/j.cell.2011.09.024
– volume: 114
  start-page: 11494
  year: 2017
  ident: 1328_CR126
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1618091114
– volume: 3
  start-page: 537
  year: 2003
  ident: 1328_CR95
  publication-title: Cancer Cell
  doi: 10.1016/S1535-6108(03)00132-6
– volume: 12
  start-page: 566
  year: 2017
  ident: 1328_CR131
  publication-title: Nat. Protoc.
  doi: 10.1038/nprot.2017.003
– volume: 406
  start-page: 747
  year: 2000
  ident: 1328_CR6
  publication-title: Nature
  doi: 10.1038/35021093
– volume: 12
  start-page: 323
  year: 2012
  ident: 1328_CR14
  publication-title: Nat. Rev. Cancer
  doi: 10.1038/nrc3261
– volume: 30
  start-page: 365
  year: 2016
  ident: 1328_CR85
  publication-title: Cancer Cell
  doi: 10.1016/j.ccell.2016.07.009
– volume: 8
  start-page: 444
  year: 2007
  ident: 1328_CR109
  publication-title: Lancet Oncol.
  doi: 10.1016/S1470-2045(07)70140-7
– volume: 25
  start-page: 605
  year: 2014
  ident: 1328_CR84
  publication-title: Cancer Cell
  doi: 10.1016/j.ccr.2014.03.021
– volume: 528
  start-page: 267
  year: 2015
  ident: 1328_CR32
  publication-title: Nature
  doi: 10.1038/nature15742
– volume: 339
  start-page: 580
  year: 2013
  ident: 1328_CR111
  publication-title: Science
  doi: 10.1126/science.1228522
– volume: 501
  start-page: 365
  year: 2013
  ident: 1328_CR37
  publication-title: Nature
  doi: 10.1038/nature12628
– volume: 8
  start-page: 381
  year: 2018
  ident: 1328_CR120
  publication-title: Front. Oncol.
  doi: 10.3389/fonc.2018.00381
– volume: 9
  year: 2018
  ident: 1328_CR86
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-017-02481-5
– volume: 74
  start-page: 6330
  year: 2014
  ident: 1328_CR115
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-14-0923
– volume: 486
  start-page: 346
  year: 2012
  ident: 1328_CR20
  publication-title: Nature
  doi: 10.1038/nature10983
– ident: 1328_CR105
  doi: 10.1098/rsif.2017.0512
– volume: 149
  start-page: 994
  year: 2012
  ident: 1328_CR30
  publication-title: Cell
  doi: 10.1016/j.cell.2012.04.023
– volume: 5
  start-page: 1228
  year: 2013
  ident: 1328_CR116
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2013.11.014
– volume: 21
  start-page: 102
  year: 2019
  ident: 1328_CR127
  publication-title: Nat. Cell Biol.
  doi: 10.1038/s41556-018-0196-y
– volume: 139
  start-page: 1315
  year: 2009
  ident: 1328_CR68
  publication-title: Cell
  doi: 10.1016/j.cell.2009.11.025
– volume: 176
  start-page: 98
  year: 2019
  ident: 1328_CR100
  publication-title: Cell
  doi: 10.1016/j.cell.2018.11.046
– volume: 22
  start-page: 725
  year: 2012
  ident: 1328_CR102
  publication-title: Cancer Cell
  doi: 10.1016/j.ccr.2012.09.022
– volume: 5
  year: 2014
  ident: 1328_CR31
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms6871
– volume: 9
  start-page: 239
  year: 2009
  ident: 1328_CR73
  publication-title: Nat. Rev. Cancer
  doi: 10.1038/nrc2618
– volume: 566
  start-page: 553
  year: 2019
  ident: 1328_CR90
  publication-title: Nature
  doi: 10.1038/s41586-019-0915-y
– volume: 10
  year: 2019
  ident: 1328_CR34
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-019-08595-2
SSID ssj0009087
Score 2.7074902
SecondaryResourceType review_article
Snippet Heterogeneity within a tumour increases its ability to adapt to constantly changing constraints, but adversely affects a patient’s prognosis, therapy response...
Heterogeneity within a tumour increases its ability to adapt to constantly changing constraints, but adversely affects a patient's prognosis, therapy response...
SourceID pubmedcentral
proquest
pubmed
crossref
springer
SourceType Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 164
SubjectTerms 631/67/322
631/80/84/2176
Biomedical and Life Sciences
Biomedicine
Breast cancer
Breast Neoplasms - genetics
Breast Neoplasms - pathology
Cancer Research
Cell Plasticity
Disease Progression
Drug Resistance
Drug Resistance, Neoplasm
Epidemiology
Epigenesis, Genetic
Epigenetics
Epithelial-Mesenchymal Transition
Female
Functional plasticity
Gene expression
Gene Expression Regulation, Neoplastic
Gene Regulatory Networks
Genetic Heterogeneity
Humans
Mesenchyme
Metastases
Microenvironments
Molecular Medicine
Oncology
Review
Review Article
Tumor microenvironment
Tumors
Title Breast cancer as an example of tumour heterogeneity and tumour cell plasticity during malignant progression
URI https://link.springer.com/article/10.1038/s41416-021-01328-7
https://www.ncbi.nlm.nih.gov/pubmed/33824479
https://www.proquest.com/docview/2553398286
https://www.proquest.com/docview/2509606241
https://pubmed.ncbi.nlm.nih.gov/PMC8292450
Volume 125
WOSCitedRecordID wos000637479300002&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
journalDatabaseRights – providerCode: PRVPQU
  databaseName: Biological Science Database
  customDbUrl:
  eissn: 1532-1827
  dateEnd: 20211231
  omitProxy: false
  ssIdentifier: ssj0009087
  issn: 0007-0920
  databaseCode: M7P
  dateStart: 20190101
  isFulltext: true
  titleUrlDefault: http://search.proquest.com/biologicalscijournals
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: Health & Medical Collection
  customDbUrl:
  eissn: 1532-1827
  dateEnd: 20211231
  omitProxy: false
  ssIdentifier: ssj0009087
  issn: 0007-0920
  databaseCode: 7X7
  dateStart: 20190101
  isFulltext: true
  titleUrlDefault: https://search.proquest.com/healthcomplete
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: Nursing & Allied Health Database
  customDbUrl:
  eissn: 1532-1827
  dateEnd: 20211231
  omitProxy: false
  ssIdentifier: ssj0009087
  issn: 0007-0920
  databaseCode: 7RV
  dateStart: 20190101
  isFulltext: true
  titleUrlDefault: https://search.proquest.com/nahs
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: ProQuest Central
  customDbUrl:
  eissn: 1532-1827
  dateEnd: 20211231
  omitProxy: false
  ssIdentifier: ssj0009087
  issn: 0007-0920
  databaseCode: BENPR
  dateStart: 20190101
  isFulltext: true
  titleUrlDefault: https://www.proquest.com/central
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: Public Health Database
  customDbUrl:
  eissn: 1532-1827
  dateEnd: 20211231
  omitProxy: false
  ssIdentifier: ssj0009087
  issn: 0007-0920
  databaseCode: 8C1
  dateStart: 20190101
  isFulltext: true
  titleUrlDefault: https://search.proquest.com/publichealth
  providerName: ProQuest
link http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3Pb9MwFH5iG0JcGL-XMSojcYNodpzVzmli0yYuVNUEqLcodmw2wZKuSRF_Pu85SatuYhcuViQ7bd33bH_2-_w9gPc-MTYtuYyNptOqhKexUQ6fjBxL7kvvSx6STajJRM9m2bQ_cGt6WuUwJ4aJuqwtnZEfIvSVMqNLz8fzm5iyRlF0tU-hsQU7pJIgA3Vvuhbd5brTzKTjuCzh_aUZLvVhkwqEIjERFCjaoGO1uTDdQZt3SZO3IqdhQTrf_d-uPIUnPRRlnzrfeQYPXPUcHn3pg-0v4OcJEdZbZskxFqxoWFEx96cgPWFWe9Yur_Ej2CURamr0Q4eAHpuUQwXFBNgc0TkRt7GquxHJrhH5_yD6DQvcsE4X5CV8Oz_7evo57nMzxDZVaRtbkrQtRIl4qxgbYxJTkq6PUzYrrJGJlerIpN4kyqRGZKWTyhe4FTdGWWG9lq9gu6ortwesdNqljntP04kXthBi7HA94MaMpXciAjEYJre9cDnlz_iVhwC61HlnzByNmQdj5iqCD6t35p1sx72tDwZD5f0QbvK1lSJ4t6rGwUf_XlG5ekltwg4QUVAErzv3WH0d7v0ROqksArXhOKsGJOy9WVNdXQaBb53grviIR_BxcLH1z_p3L_bv78UbeJwEd1c4Mx7AdrtYurfw0P5ur5rFCLbUxXcqZyqUGkt9Kkawc3I2mV6MwsD6C-pcJs8
linkProvider ProQuest
linkToHtml http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9QwEB6VgoALb0qggJHgRKM6drp2Dgjxqlq1XSFUUG8hduy2gmaXTZbHn-I3MuMku1oqeuuBWyQ7DzufxzP2528AnnphbFpyGRtNq1WCp7FRDq-MHEjuS-9LHpJNqOFQHxxk75fgd38WhmiVvU0MhrocWVojX0fXV8qMDj2_HH-LKWsU7a72KTRaWOy4Xz8wZKtfbL_F__tMiM13-2-24i6rQGxTlTaxJTHWIinRUygGxhhhSlKkccpmhTVSWKk2TOqNUCY1SVY6qXyBQaQxyibWa4nPvQAX0Y4nRCFTHz7NRX65bjU6afkvE7w7pMOlXq_TBF2fmAgRtLuhY7U4EZ7ybk-TNP_aqQ0T4Ob1_63rbsC1ztVmr9qxcROWXHULLu91ZILb8OU1EfIbZgn4E1bUrKiY-1mQXjIbedZMT_AR7IgIQyMcZw4DFqxS9gW058HGGH0QMR2L2hOf7AQjm0OiF7HAfWt1T-7Ax3Np6l1YrkaVuwesdNqljntP5tIntkiSgcP5jhszkN4lESQ9EHLbCbNTfpCveSAISJ234MkRPHkAT64ieD67Z9zKkpxZe7UHRt6ZqDqfoyKCJ7NiNC7Ue0XlRlOqEyJc9PIiWGnhOHudlBpdQ5VFoBaAOqtAwuWLJdXxURAw1wKj_g0ewVoP6fln_bsV989uxWO4srW_t5vvbg93HsBVEYaawllgFZabydQ9hEv2e3NcTx6FQcvg83lD_Q92hYEG
linkToPdf http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9QwEB6VgiouvB-BAkaCE0Tr2OnaOSAELSuqwqoHkHoLsWPTqm2y7GZ5_DV-HTNOsqulorceuK1kJ1kn34xn7M_fADzzwti05DI2mlarBE9joxz-MnIouS-9L3koNqHGY31wkO2vwe_-LAzRKnufGBx1WVtaIx9g6CtlRoeeB76jRezvjF5PvsVUQYp2WvtyGi1E9tyvH5i-zV7t7uC3fi7E6N2n7fdxV2EgtqlKm9iSMGuRlBg1FENjjDAlqdM4ZbPCGimsVFsm9UYok5okK51UvsCE0hhlE-u1xPtegssKx0V0Mr29pJdkXLd6nbQUmAneHdjhUg9maYJhUEzkCNrp0LFanRTPRLpnCZt_7dqGyXB0_X9-jTfgWheCszetzdyENVfdgo2PHcngNhy_JaJ-wywZxJQVM1ZUzP0sSEeZ1Z4181O8BTskIlGN9ucwkcEuZd9AeyFsglkJEdaxqT0Jyk4x4_lKtCMWOHGtHsod-HwhQ70L61VdufvASqdd6rj35EZ9YoskGTqcB7kxQ-ldEkHSgyK3nWA71Q05yQNxQOq8BVKOQMoDkHIVwYvFNZNWruTc3ps9SPLOdc3yJUIieLpoRqdDb6-oXD2nPiHzxegvgnstNBePk1JjyKiyCNQKaBcdSNB8taU6OgzC5lpkIt3iEbzs4b38W_8exYPzR_EENhDh-Yfd8d5DuCqC1SmcHDZhvZnO3SO4Yr83R7Pp42C_DL5cNNL_AAF2iWE
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Breast+cancer+as+an+example+of+tumour+heterogeneity+and+tumour+cell+plasticity+during+malignant+progression&rft.jtitle=British+journal+of+cancer&rft.au=L%C3%BC%C3%B6nd%2C+Fabiana&rft.au=Tiede%2C+Stefanie&rft.au=Christofori%2C+Gerhard&rft.date=2021-07-20&rft.eissn=1532-1827&rft.volume=125&rft.issue=2&rft.spage=164&rft_id=info:doi/10.1038%2Fs41416-021-01328-7&rft_id=info%3Apmid%2F33824479&rft.externalDocID=33824479
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0007-0920&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0007-0920&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0007-0920&client=summon