Mechanisms of PARP inhibitor sensitivity and resistance

BRCA1 and BRCA2 deficient tumor cells are sensitive to inhibitors of Poly ADP Ribose Polymerase (PARP1) through the mechanism of synthetic lethality. Several PARP inhibitors, which are oral drugs and generally well tolerated, have now received FDA approval for various ovarian cancer and breast cance...

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Bibliographic Details

Published in:	DNA repair Vol. 71; pp. 172 - 176
Main Author:	D’Andrea, Alan D.
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01.11.2018
Subjects:	BRCA1/2 Homologous recombination PARP1 Replication fork BRCA1/2 Replication fork PARP1 Homologous recombination
ISSN:	1568-7864, 1568-7856, 1568-7856
Online Access:	Get full text
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