MicroRaman spectroscopy detects the presence of microplastics in human urine and kidney tissue

[Display omitted] •Recent evidence reports microplastics’ presence in human tissues and fluids.•MicroRaman spectroscopy is employed to detect microplastics in biological samples.•66 microparticles fragments were found in 10 kidney tissues and 10 urine samples and 26 out 66 were characterized.•SpeCom...

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Vydáno v:Environment international Ročník 184; s. 108444
Hlavní autoři: Massardo, Sara, Verzola, Daniela, Alberti, Stefano, Caboni, Claudia, Santostefano, Matteo, Eugenio Verrina, Enrico, Angeletti, Andrea, Lugani, Francesca, Ghiggeri, Gian Marco, Bruschi, Maurizio, Candiano, Giovanni, Rumeo, Noemi, Gentile, Micaela, Cravedi, Paolo, La Maestra, Sebastiano, Zaza, Gianluigi, Stallone, Giovanni, Esposito, Pasquale, Viazzi, Francesca, Mancianti, Nicoletta, La Porta, Edoardo, Artini, Cristina
Médium: Journal Article
Jazyk:angličtina
Vydáno: Netherlands Elsevier Ltd 01.02.2024
Elsevier
Témata:
Environmental Monitoring - methods
Humans
Kidney
Kidney - chemistry
Micro-Raman spectroscopy
Microplastics
Pigments
Plastics - chemistry
Polymers
Spectrum Analysis
Urine
Water Pollutants, Chemical - analysis
Urine
PP
HQI
PS
SEBS
POPs
IR
K
Kidney
MPs
PMMA
NC
PE
U
Pigments
PAHs
Microplastics
SEM
PVC
TEM
PET
Micro-Raman spectroscopy
ISSN:0160-4120, 1873-6750, 1873-6750
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Shrnutí:[Display omitted] •Recent evidence reports microplastics’ presence in human tissues and fluids.•MicroRaman spectroscopy is employed to detect microplastics in biological samples.•66 microparticles fragments were found in 10 kidney tissues and 10 urine samples and 26 out 66 were characterized.•SpeComp open-access software was developed to ease microRaman spectra comparison.•The most often detected pieces and pigments are polyethylene, polystyrene, hematite. There is a growing concern within the medical community about the potential burden of microplastics on human organs and tissues. In this study, we investigated by microRaman spectroscopy the presence of microplastics in human kidneys and urine. Moreover, an open-access software was developed and validated for the project, which enabled the comparison between the investigated spectra and a self-created spectral database, thus enhancing the ability to characterize polymers and pigments in biological matrices. Healthy portions of ten kidneys obtained from nephrectomies, as well as ten urine samples from healthy donors were analyzed: 26 particles in both kidney and urine samples were identified, with sizes ranging from 3 to 13 μm in urine and from 1 to 29 μm in kidneys. The most frequently determined polymers are polyethylene and polystyrene, while the most common pigments are hematite and Cu-phthalocyanine. This preclinical study proves the presence of microplastics in renal tissues and confirms their presence in urine, providing the first evidence of kidney microplastics deposition in humans.
Bibliografie:ObjectType-Article-1
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ISSN:0160-4120
1873-6750
1873-6750
DOI:10.1016/j.envint.2024.108444