IL-1β/IL-6/CRP and IL-18/ferritin: Distinct Inflammatory Programs in Infections

The host inflammatory response against infections is characterized by the release of pro-inflammatory cytokines and acute-phase proteins, driving both innate and adaptive arms of the immune response. Distinct patterns of circulating cytokines and acute-phase responses have proven indispensable for g...

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Bibliographic Details
Published in:PLoS pathogens Vol. 12; no. 12; p. e1005973
Main Authors: Slaats, Jeroen, ten Oever, Jaap, van de Veerdonk, Frank L., Netea, Mihai G.
Format: Journal Article
Language:English
Published: United States Public Library of Science 01.12.2016
Public Library of Science (PLoS)
Subjects:
Acute-Phase Proteins - immunology
Animals
Bacterial Infections - immunology
Biology and Life Sciences
C-Reactive Protein - immunology
Cytokines - immunology
Ferritins - immunology
Humans
Inflammation - immunology
Inflammation Mediators - immunology
Interleukin-18 - immunology
Interleukin-1beta - immunology
Interleukin-6 - immunology
Medicine and Health Sciences
Review
Virus Diseases - immunology
ISSN:1553-7374, 1553-7366, 1553-7374
Online Access:Get full text
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Summary:The host inflammatory response against infections is characterized by the release of pro-inflammatory cytokines and acute-phase proteins, driving both innate and adaptive arms of the immune response. Distinct patterns of circulating cytokines and acute-phase responses have proven indispensable for guiding the diagnosis and management of infectious diseases. This review discusses the profiles of acute-phase proteins and circulating cytokines encountered in viral and bacterial infections. We also propose a model in which the inflammatory response to viral (IL-18/ferritin) and bacterial (IL-6/CRP) infections presents with specific plasma patterns of immune biomarkers.
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The authors have declared that no competing interests exist.
ISSN:1553-7374
1553-7366
1553-7374
DOI:10.1371/journal.ppat.1005973