Evaluating the potential role of pleiotropy in Mendelian randomization studies

Abstract Pleiotropy, the phenomenon of a single genetic variant influencing multiple traits, is likely widespread in the human genome. If pleiotropy arises because the single nucleotide polymorphism (SNP) influences one trait, which in turn influences another ('vertical pleiotropy'), then...

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Bibliographic Details

Published in:	Human molecular genetics Vol. 27; no. R2; pp. R195 - R208
Main Authors:	Hemani, Gibran, Bowden, Jack, Davey Smith, George
Format:	Journal Article
Language:	English
Published:	England Oxford University Press 01.08.2018
Subjects:	Animals Genetic Pleiotropy - genetics Genetic Pleiotropy - physiology Genetic Variation Genome, Human Genome-Wide Association Study Humans Mendelian Randomization Analysis - methods Phenotype Polymorphism, Single Nucleotide - genetics Reproducibility of Results
ISSN:	0964-6906, 1460-2083, 1460-2083
Online Access:	Get full text
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