γδ T cells are effectors of immunotherapy in cancers with HLA class I defects

DNA mismatch repair-deficient (MMR-d) cancers present an abundance of neoantigens that is thought to explain their exceptional responsiveness to immune checkpoint blockade (ICB) 1 , 2 . Here, in contrast to other cancer types 3 – 5 , we observed that 20 out of 21 (95%) MMR-d cancers with genomic ina...

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Veröffentlicht in:	Nature (London) Jg. 613; H. 7945; S. 743 - 750
Hauptverfasser:	de Vries, Natasja L., van de Haar, Joris, Veninga, Vivien, Chalabi, Myriam, Ijsselsteijn, Marieke E., van der Ploeg, Manon, van den Bulk, Jitske, Ruano, Dina, van den Berg, Jose G., Haanen, John B., Zeverijn, Laurien J., Geurts, Birgit S., de Wit, Gijs F., Battaglia, Thomas W., Gelderblom, Hans, Verheul, Henk M. W., Schumacher, Ton N., Wessels, Lodewyk F. A., Koning, Frits, de Miranda, Noel F. C. C., Voest, Emile E.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 26.01.2023 Nature Publishing Group
Schlagworte:	13/1 13/2 13/21 13/31 13/51 38/91 45/23 631/250/1619/554/2509 631/250/21 631/250/580 631/67/1059/2325 631/67/1504/1885/1393 82/80 Antigen Presentation Antigens beta 2-Microglobulin - deficiency beta 2-Microglobulin - genetics Biopsy Cancer Cancer immunotherapy CD8 antigen Cell Line, Tumor Colon cancer Colonic Neoplasms - drug therapy Colonic Neoplasms - genetics Colonic Neoplasms - immunology Colonic Neoplasms - therapy Colorectal cancer CTLA-4 protein Cytotoxicity Deactivation DNA Mismatch Repair - genetics DNA repair Effector cells Genes Genes, MHC Class I - genetics Histocompatibility antigen HLA Histocompatibility Antigens Class I - genetics Histocompatibility Antigens Class I - immunology Humanities and Social Sciences Humans Immune checkpoint inhibitors Immune Checkpoint Inhibitors - pharmacology Immune Checkpoint Inhibitors - therapeutic use Immunoglobulin-like receptors Immunoglobulins Immunotherapy Inactivation Leukocytes Lymphocytes Lymphocytes T Mann-Whitney U test Metastases Mismatch repair multidisciplinary Mutation Neoantigens Organoids Patients PD-1 protein Receptors, Antigen, T-Cell, gamma-delta - immunology Receptors, KIR Regression analysis Science Science (multidisciplinary) T cell receptors T-Lymphocytes - immunology Tumor cell lines Tumors β2 Microglobulin
ISSN:	0028-0836, 1476-4687, 1476-4687
Online-Zugang:	Volltext
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