Medication-related adverse events in health care—what have we learned? A narrative overview of the current knowledge

Purpose Although medication-related adverse events (MRAEs) in health care are vastly studied, high heterogeneity in study results complicates the interpretations of the current situation. The main objective of this study was to form an up-to-date overview of the current knowledge of the prevalence,...

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Vydáno v:European journal of clinical pharmacology Ročník 78; číslo 2; s. 159 - 170
Hlavní autoři: Laatikainen, O., Sneck, S., Turpeinen, M.
Médium: Journal Article
Jazyk:angličtina
Vydáno: Berlin/Heidelberg Springer Berlin Heidelberg 01.02.2022
Springer Nature B.V
Témata:
Age Factors
Biomedical and Life Sciences
Biomedicine
Drug-Related Side Effects and Adverse Reactions - economics
Drug-Related Side Effects and Adverse Reactions - epidemiology
Health care
Humans
Liver Failure - epidemiology
Long-term effects
Medication Errors - adverse effects
Medication Errors - statistics & numerical data
Meta-Analysis as Topic
Morbidity
Multimorbidity
Patients
Pharmacology/Toxicology
Pharmacovigilance
Polypharmacy - statistics & numerical data
Population studies
Renal Insufficiency - epidemiology
Review
Risk Factors
Systematic Reviews as Topic
Health care
Patient safety
Patient harm
Medication-related adverse events
Medication errors
Adverse drug events
ISSN:0031-6970, 1432-1041, 1432-1041
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Shrnutí:Purpose Although medication-related adverse events (MRAEs) in health care are vastly studied, high heterogeneity in study results complicates the interpretations of the current situation. The main objective of this study was to form an up-to-date overview of the current knowledge of the prevalence, risk factors, and surveillance of MRAEs in health care. Methods Electronic databases (PubMed, MEDLINE, Web of Science, and Scopus) were searched with applicable search terms to collect information on medication-related adverse events. In order to obtain an up-to-date view of MRAEs, only studies published after 2000 were accepted. Results The prevalence rates of different MRAEs vary greatly between individual studies and meta-analyses. Study setting, patient population, and detection methods play an important role in determining detection rates, which should be regarded while interpreting the results. Medication-related adverse events are more common in elderly patients and patients with lowered liver or kidney function, polypharmacy, and a large number of additional comorbidities. However, the risk of MRAEs is also significantly increased by the use of high-risk medicines but also in certain care situations. Preventing MRAEs is important as it will decrease patient mortality and morbidity but also reduce costs and functional challenges related to them. Conclusions Medication-related adverse events are highly common and have both immediate and long-term effects to patients and healthcare systems worldwide. Conclusive solutions for prevention of all medication-related harm are impossible to create. In the future, however, the development of efficient real-time detection methods can provide significant improvements for event prevention and forecasting.
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ISSN:0031-6970
1432-1041
1432-1041
DOI:10.1007/s00228-021-03213-x