Improved immunocompatibility of active targeting liposomes by attenuating nucleophilic attack of cyclic RGD peptides on complement 3

One of the challenges for the clinical translation of active targeting nanomedicines is the adverse interactions between targeting ligands and blood components. Herein, a novel regularity, which reveals the interactions between cyclic RGD (Arg-Gly-Asp) peptide-modified liposomes and complement compo...

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Bibliographic Details
Published in:	Biomaterials Vol. 321; p. 123350
Main Authors:	Meng, Nana, Lu, Jiasheng, Zhou, Jianfen, Yang, Shengmin, Zhang, Chen, Jia, Ruiyi, Ding, Yuan, Bao, Yanning, Wang, Jun, Ma, Xiaopei, Chen, Ruohan, Jiang, Zhixuan, Xie, Cao, Lu, Linwei, Lu, Weiyue
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier Ltd 01.10.2025
Subjects:	Animals antibody formation arginine biocompatible materials blood breast neoplasms Cell Line, Tumor complement Complement activation Complement C3 - chemistry Complement C3 - immunology Complement C3 - metabolism Female glioma guanidines Humans Immunocompatibility Integrin alphaVbeta3 - metabolism integrins Lewis bases ligands Liposomes Liposomes - chemistry Mice Mice, Inbred BALB C nanomedicine Nucleophilicity peptides Peptides, Cyclic - chemistry Peptides, Cyclic - immunology Pharmacodynamics Pharmacokinetics reticuloendothelial system RGD peptide Complement activation Pharmacodynamics Immunocompatibility RGD peptide Liposomes Pharmacokinetics Nucleophilicity
ISSN:	0142-9612, 1878-5905, 1878-5905
Online Access:	Get full text
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