How I treat disseminated intravascular coagulation

Disseminated intravascular coagulation (DIC) is a condition characterized by systemic activation of coagulation, potentially leading to thrombotic obstruction of small and midsize vessels, thereby contributing to organ dysfunction. At the same time, ongoing consumption of platelets and coagulation p...

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Bibliographic Details
Published in:Blood Vol. 131; no. 8; p. 845
Main Authors: Levi, Marcel, Scully, Marie
Format: Journal Article
Language:English
Published: United States 22.02.2018
Subjects:
Aged
Anticoagulants - therapeutic use
Disease Management
Disseminated Intravascular Coagulation - drug therapy
Female
Humans
Male
Middle Aged
ISSN:1528-0020, 1528-0020
Online Access:Get more information
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Summary:Disseminated intravascular coagulation (DIC) is a condition characterized by systemic activation of coagulation, potentially leading to thrombotic obstruction of small and midsize vessels, thereby contributing to organ dysfunction. At the same time, ongoing consumption of platelets and coagulation proteins results in thrombocytopenia and low concentrations of clotting factors, which may cause profuse hemorrhagic complications. DIC is always secondary to an underlying condition, such as severe infections, solid or hematologic malignancies, trauma, or obstetric calamities. A reliable diagnosis of DIC can be made through simple scoring algorithms based on readily available routine hemostatic parameters. The cornerstone of supportive treatment of this coagulopathy is management of the underlying condition. Additionally, administration of heparin may be useful, and restoration of physiological anticoagulants has been suggested, but has not been proven successful in improving clinically relevant outcomes so far. In patients with major bleeding or at risk for hemorrhagic complications, administration of platelet concentrates, plasma, or coagulation factor concentrates should be considered.
Bibliography:ObjectType-Case Study-2
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ISSN:1528-0020
1528-0020
DOI:10.1182/blood-2017-10-804096