How I treat disseminated intravascular coagulation

Disseminated intravascular coagulation (DIC) is a condition characterized by systemic activation of coagulation, potentially leading to thrombotic obstruction of small and midsize vessels, thereby contributing to organ dysfunction. At the same time, ongoing consumption of platelets and coagulation p...

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Vydané v:Blood Ročník 131; číslo 8; s. 845
Hlavní autori: Levi, Marcel, Scully, Marie
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: United States 22.02.2018
Predmet:
Aged
Anticoagulants - therapeutic use
Disease Management
Disseminated Intravascular Coagulation - drug therapy
Female
Humans
Male
Middle Aged
ISSN:1528-0020, 1528-0020
On-line prístup:Zistit podrobnosti o prístupe
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Shrnutí:Disseminated intravascular coagulation (DIC) is a condition characterized by systemic activation of coagulation, potentially leading to thrombotic obstruction of small and midsize vessels, thereby contributing to organ dysfunction. At the same time, ongoing consumption of platelets and coagulation proteins results in thrombocytopenia and low concentrations of clotting factors, which may cause profuse hemorrhagic complications. DIC is always secondary to an underlying condition, such as severe infections, solid or hematologic malignancies, trauma, or obstetric calamities. A reliable diagnosis of DIC can be made through simple scoring algorithms based on readily available routine hemostatic parameters. The cornerstone of supportive treatment of this coagulopathy is management of the underlying condition. Additionally, administration of heparin may be useful, and restoration of physiological anticoagulants has been suggested, but has not been proven successful in improving clinically relevant outcomes so far. In patients with major bleeding or at risk for hemorrhagic complications, administration of platelet concentrates, plasma, or coagulation factor concentrates should be considered.
Bibliografia:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
ObjectType-Review-5
ObjectType-Feature-4
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ObjectType-Report-1
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ISSN:1528-0020
1528-0020
DOI:10.1182/blood-2017-10-804096