Mechanisms and Management of Retinopathy of Prematurity

This article reviews retinopathy of prematurity, particularly regarding oxygen use, and describes current and potential therapies based on mechanistic studies in models relevant to current oxygen stresses in preterm infants. Retinopathy of prematurity is a vision-threatening disease associated with...

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Bibliographic Details
Published in:The New England journal of medicine Vol. 367; no. 26; pp. 2515 - 2526
Main Authors: Hartnett, M. Elizabeth, Penn, John S
Format: Journal Article
Language:English
Published: Waltham, MA Massachusetts Medical Society 27.12.2012
Series:Medical Progress
Subjects:
Animals
Antioxidants - therapeutic use
Biological and medical sciences
Erythropoietin - therapeutic use
General aspects
Humans
Infant, Newborn
Infant, Premature
Infant, Very Low Birth Weight
Medical sciences
Models, Animal
Ophthalmology
Oxygen - adverse effects
Retinal Vessels - growth & development
Retinal Vessels - pathology
Retinopathies
Retinopathy of Prematurity - diagnosis
Retinopathy of Prematurity - etiology
Retinopathy of Prematurity - physiopathology
Retinopathy of Prematurity - therapy
Vascular Endothelial Growth Factor A - antagonists & inhibitors
Medicine
Eye disease
Clinical management
Retinopathy
Prematurity
Mechanism
ISSN:0028-4793, 1533-4406, 1533-4406
Online Access:Get full text
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Summary:This article reviews retinopathy of prematurity, particularly regarding oxygen use, and describes current and potential therapies based on mechanistic studies in models relevant to current oxygen stresses in preterm infants. Retinopathy of prematurity is a vision-threatening disease associated with abnormal retinal vascular development that occurs only in premature infants. 1 Low birth weight and prematurity are strongly associated with an increased risk of the disease. 2 In the Early Treatment for Retinopathy of Prematurity study, the disorder developed in 68% of premature infants born in the United States and weighing less than 1251 g; among infants with the disorder, severe retinopathy of prematurity developed in almost 37%. 1 The incidence of premature births is increasing throughout the world, and with it, retinopathy of prematurity is now appearing in countries with the technology to . . .
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ISSN:0028-4793
1533-4406
1533-4406
DOI:10.1056/NEJMra1208129