Association of plasma endothelin-1 with blood pressure progression among Blacks: The Jackson Heart Study

Despite pathophysiological links between endothelin (ET)-1 and hypertension in Black adults, there is no population-based data appraising the association of plasma ET-1 with longitudinal blood pressure (BP) changes in Blacks. We analyzed data from 1197 Jackson Heart Study participants without hypert...

Celý popis

Uložené v:
Podrobná bibliografia
Vydané v:The American heart journal Ročník 246; s. 144 - 151
Hlavní autori: Kaze, Arnaud D., Gao, Xiang, Musani, Solomon K., Bidulescu, Aurelian, Bertoni, Alain G., Abdalla, Marwah, Echouffo-Tcheugui, Justin B.
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: United States Elsevier Inc 01.04.2022
Elsevier Limited
Predmet:
Adult
Alcohol
Antihypertensives
Black or African American
Blood pressure
Blood Pressure - physiology
Body mass index
Cardiology
Cholesterol
Confidence intervals
Diabetes
Endothelin 1
Endothelin-1 - therapeutic use
Female
Heart
High density lipoprotein
Humans
Hypertension
Hypertension - drug therapy
Kidney diseases
Longitudinal Studies
Male
Middle Aged
Minority & ethnic groups
Plasma
Risk Factors
Robustness (mathematics)
Statistical analysis
United States - epidemiology
Variables
United States
ISSN:0002-8703, 1097-6744, 1097-6744
On-line prístup:Získať plný text
Tagy: Pridať tag
Žiadne tagy, Buďte prvý, kto otaguje tento záznam!
Popis
Shrnutí:Despite pathophysiological links between endothelin (ET)-1 and hypertension in Black adults, there is no population-based data appraising the association of plasma ET-1 with longitudinal blood pressure (BP) changes in Blacks. We analyzed data from 1197 Jackson Heart Study participants without hypertension (mean age 47.8 years [SD: 12.0]; 64.2% women), with plasma ET-1 available at the baseline examination (2000-2004). Poisson regression with robust variance was used to generate risk ratios (RRs) and 95% confidence intervals (CIs) of BP progression (an increase by ≥1 BP category based on the 2017 American College of Cardiology/American Heart Association classification) and incident hypertension (BP ≥ 130/80 mm Hg or use of antihypertensive medication) at follow-up (2005-2008 or 2009-2013). Over a median follow-up of 7 years (range: 4-11), 71.2% (n = 854) progressed to a higher BP stage and 64.6% (n = 773) developed hypertension. After adjusting for possible confounders, each unit increment in baseline log (ET-1) was associated with higher risks of BP progression (RR 1.15 [95% CI 1.03-1.29], P = .016) and incident hypertension (RR 1.15 [95% CI 1.01-1.31], P = .032). Compared to those in the lowest ET-1 quartile, participants in the highest quartile had significantly higher risks of BP progression (RR 1.20 [95% CI 1.05-1.37], P = .007) and incident hypertension (RR 1.16 [95% CI 1.00-1.36], P = .052). In a large, community-based sample of African Americans, higher plasma ET-1 concentrations were associated with higher risks of BP progression and incident hypertension.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
ISSN:0002-8703
1097-6744
1097-6744
DOI:10.1016/j.ahj.2021.12.016