Calcineurin inhibitor Tacrolimus impairs host immune response against urinary tract infection

Calcineurin inhibitor Tacrolimus, is a potent immunosuppressive drug widely used in order to prevent acute graft rejection. Urinary tract infection (UTI) is the most frequent infectious complication in renal transplant patients and long-term use of Tacrolimus might be involved in higher susceptibili...

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Bibliographic Details
Published in:	Scientific reports Vol. 9; no. 1; p. 106
Main Authors:	Emal, Diba, Rampanelli, Elena, Claessen, Nike, Bemelman, Frederike J., Leemans, Jaklien C., Florquin, Sandrine, Dessing, Mark C.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 14.01.2019 Nature Publishing Group
Subjects:	13 13/1 13/31 13/51 38/77 631/250/255/1318 631/80/304 82/80 Activating transcription factor 3 Animals Bacteremia Bacterial diseases Bacterial infections Bacterial Load Calcineurin Calcineurin inhibitors Calcineurin Inhibitors - administration & dosage Calcineurin Inhibitors - adverse effects CXCR2 protein Cystitis Disease Models, Animal E coli Escherichia coli Infections - immunology Escherichia coli Infections - pathology Female Graft rejection Granulocytes Granulocytes - drug effects Granulocytes - immunology Humanities and Social Sciences Immune response Immunologic Factors - metabolism Immunosuppressive agents Immunosuppressive Agents - administration & dosage Immunosuppressive Agents - adverse effects Innate immunity Inoculation Kidney transplantation Leukocytes (granulocytic) Macrophages Mice multidisciplinary Peroxidase - metabolism Phagocytosis - drug effects Pyelonephritis Rodents Science Science (multidisciplinary) Tacrolimus Tacrolimus - administration & dosage Tacrolimus - adverse effects TLR5 protein Toll-like receptors Urinary tract Urinary tract diseases Urinary tract infections Urinary Tract Infections - immunology Urinary Tract Infections - pathology Urogenital system Uropathogenic Escherichia coli - growth & development Uropathogenic Escherichia coli - immunology
ISSN:	2045-2322, 2045-2322
Online Access:	Get full text
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