Targeting TOPK sensitises tumour cells to radiation-induced damage by enhancing replication stress

T-LAK-originated protein kinase (TOPK) overexpression is a feature of multiple cancers, yet is absent from most phenotypically normal tissues. As such, TOPK expression profiling and the development of TOPK-targeting pharmaceutical agents have raised hopes for its future potential in the development...

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Bibliographic Details
Published in:	Cell death and differentiation Vol. 28; no. 4; pp. 1333 - 1346
Main Authors:	Herbert, Katharine J, Puliyadi, Rathi, Prevo, Remko, Rodriguez-Berriguete, Gonzalo, Ryan, Anderson, Ramadan, Kristijan, Higgins, Geoff S
Format:	Journal Article
Language:	English
Published:	England Nature Publishing Group 01.04.2021
Subjects:	Animals Apoptosis - drug effects Apoptosis - radiation effects cdc25 Phosphatases - drug effects cdc25 Phosphatases - genetics cdc25 Phosphatases - radiation effects Cell Line, Tumor Checkpoint Kinase 1 - drug effects Checkpoint Kinase 1 - genetics Checkpoint Kinase 1 - radiation effects CHK1 protein Deoxyribonucleic acid DNA DNA biosynthesis DNA damage Drug development Female Humans Kinases Lung cancer Lung Neoplasms - metabolism Lung Neoplasms - radiotherapy Mice Mice, Nude Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors Mitogen-Activated Protein Kinase Kinases - genetics Mitogen-Activated Protein Kinase Kinases - metabolism Protein kinase Protein Kinase Inhibitors - pharmacology Quinolones - pharmacology Radiation Radiation Tolerance - drug effects Radiation Tolerance - genetics S phase Signal Transduction Single-stranded DNA Solid tumors Survival Rate Xenograft Model Antitumor Assays Xenografts
ISSN:	1350-9047, 1476-5403, 1476-5403
Online Access:	Get full text
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