The prevalence and risk of symptom and function clusters in colorectal cancer survivors

Purpose Our purpose was to describe the prevalence and predictors of symptom and function clusters in a diverse cohort of colorectal cancer survivors. Methods We used data from a cohort of 909 adult colorectal cancer survivors. Participants were surveyed at a median of 9 months after diagnosis to as...

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Vydáno v:Journal of cancer survivorship Ročník 16; číslo 6; s. 1449 - 1460
Hlavní autoři: Potosky, Arnold L., Graves, Kristi D., Lin, Li, Pan, Wei, Fall-Dickson, Jane M., Ahn, Jaeil, Ferguson, Kristin M., Keegan, Theresa H. M., Paddock, Lisa E., Wu, Xiao-Cheng, Cress, Rosemary, Reeve, Bryce B.
Médium: Journal Article
Jazyk:angličtina
Vydáno: New York Springer US 01.12.2022
Springer Nature B.V
Témata:
Adult
Cancer
Cancer Survivors
Chemotherapy
Colorectal cancer
Colorectal carcinoma
Colorectal Neoplasms - epidemiology
Colorectal Neoplasms - psychology
Factor analysis
Female
Health Informatics
Health Promotion and Disease Prevention
Humans
Medicine
Medicine & Public Health
Mental disorders
Oncology
Prevalence
Primary Care Medicine
Public Health
Quality of life
Quality of Life - psychology
Quality of Life Research
Regression analysis
Risk factors
Survivors - psychology
Well being
Cancer survivors
Colorectal neoplasms
Symptom assessment
Quality of life
Population health
ISSN:1932-2259, 1932-2267, 1932-2267
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Shrnutí:Purpose Our purpose was to describe the prevalence and predictors of symptom and function clusters in a diverse cohort of colorectal cancer survivors. Methods We used data from a cohort of 909 adult colorectal cancer survivors. Participants were surveyed at a median of 9 months after diagnosis to ascertain the co-occurrence of eight distinct symptom and functional domains. We used factor analysis to identify co-occurring domains and latent profile analysis (LPA) to identify subgroups of survivors with different symptom and function clusters. Multinomial logistic regression models were used to identify risk/protective factors. Results Factor analysis demonstrated a single underlying factor structure that included all eight health domains with depression and anxiety highly correlated ( r  = 0.87). The LPA identified three symptom and function clusters, with 30% of survivors in the low health-related quality of life (HRQOL) profile having the highest symptom burden and lowest functioning. In multivariable models, survivors more likely to be in the low HRQOL profile included being non-White, female, those with a history of cardiac or mental health conditions, and chemotherapy recipients. Survivors less likely to be in the low HRQOL profile included those with older age, greater financial well-being, and more spirituality. Conclusion Nearly one-third of colorectal cancer survivors experienced a cluster of physical and psychosocial symptoms that co-occur with clinically relevant deficits in function. Implications for Cancer Survivors Improving the identification of risk factors for having the highest symptom and lowest function profile can inform the development of clinical interventions to mitigate their adverse impact on cancer survivors’ HRQOL.
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Author contribution ALP was responsible for funding acquisition, supervision, project administration, data curation, and the original draft; BBR and LL were responsible for formal analysis; BBR, LL, and WP were responsible for methodology; all authors contributed to study conceptualization, and review and editing.
ISSN:1932-2259
1932-2267
1932-2267
DOI:10.1007/s11764-021-01123-6