Side effects of topical atropine 0.05% compared to 0.01% for myopia control in German school children: a pilot study

Purpose Based on findings of the Asian low-concentration atropine for myopia progression study, a concentration of 0.05% has been proposed as a good compromise between safety and efficacy for myopia control. However, no data on side effects have been published so far in Caucasian children receiving...

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Veröffentlicht in:International ophthalmology Jg. 41; H. 6; S. 2001 - 2008
Hauptverfasser: Joachimsen, Lutz, Farassat, Navid, Bleul, Tim, Böhringer, Daniel, Lagrèze, Wolf A., Reich, Michael
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Dordrecht Springer Netherlands 01.06.2021
Springer Nature B.V
Schlagworte:
Accommodation
Acuity
Atropine
Children
Eye
Eye (anatomy)
Medicine
Medicine & Public Health
Myopia
Ophthalmology
Original Paper
Pupil size
Side effects
Visual acuity
Caucasian
Side effects
Children
Low-dose atropine
Europe
Myopia
ISSN:0165-5701, 1573-2630, 1573-2630
Online-Zugang:Volltext
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Zusammenfassung:Purpose Based on findings of the Asian low-concentration atropine for myopia progression study, a concentration of 0.05% has been proposed as a good compromise between safety and efficacy for myopia control. However, no data on side effects have been published so far in Caucasian children receiving this dose. Methods Prior to commencement of bilateral atropine treatment with 0.05% atropine, 19 myopic children aged 5 to 15 years were treated in only one eye at bedtime leaving the other eye as a control. Pupil size, accommodation amplitude and near visual acuity were measured at 10:00 a.m. the next day and compared to the untreated contralateral control eye. The results were then compared to a cohort of 18 children whose treatment with 0.01% atropine commenced in a similar fashion. Results Twelve children (63%) reported visual impairment or reading difficulties. Anisocoria was 2.9 ± 1.1 mm. In comparison, 0.01% atropine led to a significantly less anisocoria of 0.8 ± 0.7 mm ( p  < 0.0001). Accommodation was decreased by − 4.2 ± 3.8 D in 0.05% atropine treated eyes, whereas 0.01% atropine induced hypoaccommodation of − 0.05 ± 2.5 D ( p  < 0.01). Near visual acuity was not significantly reduced in eyes treated with 0.05% atropine compared to 0.01% atropine ( p  = 0.26). Conclusion Compared to 0.01%, our data indicate stronger more relevant side effects of 0.05% topical atropine in young Caucasian children with progressive myopia as recently reported in Asian children, potentially compromising acceptance and compliance.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0165-5701
1573-2630
1573-2630
DOI:10.1007/s10792-021-01755-8