DICER: structure, function, and regulation

Regulation of gene expression by small non-coding RNAs, such as miRNAs and siRNAs, is an inherent part of complex biological processes that allow function and survival of eukaryotic cells. The type III ribonuclease DICER is widely recognized as a key step in the production of miRNAs and siRNAs, alth...

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Vydané v:Biophysical reviews Ročník 13; číslo 6; s. 1081 - 1090
Hlavní autori: Vergani-Junior, Carlos A., Tonon-da-Silva, Guilherme, Inan, Mehmet Dinçer, Mori, Marcelo A.
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Berlin/Heidelberg Springer Berlin Heidelberg 01.12.2021
Springer Nature B.V
Predmet:
Aging
Apoptosis
Biochemistry
Biological activity
Biological and Medical Physics
Biological Techniques
Biomedical and Life Sciences
Biophysics
Cell Biology
Deregulation
DNA repair
Gene expression
Life Sciences
Membrane Biology
Nanotechnology
Regulatory mechanisms (biology)
Review
Ribonuclease III
siRNA
Structure-function relationships
Aging
RNAi
DICER
miRNAs
ISSN:1867-2450, 1867-2469
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Popis
Shrnutí:Regulation of gene expression by small non-coding RNAs, such as miRNAs and siRNAs, is an inherent part of complex biological processes that allow function and survival of eukaryotic cells. The type III ribonuclease DICER is widely recognized as a key step in the production of miRNAs and siRNAs, although it also has non-canonical functions such as DNA repair and induction of apoptosis. DICER is at the cornerstone of most biological processes; hence, its mRNA and protein levels are subject to multiple layers of regulation. Accordingly, DICER derangement is related to disease and leads to accelerated aging. Interventions that boost DICER function hold great potential as strategies to promote health and longevity. In this review, we will summarize the structural features of DICER, describe its canonical and non-canonical roles, and discuss the most common regulatory mechanisms having an impact on DICER abundance and function. We will also touch upon the current literature demonstrating that DICER deregulation can lead to diseases, thus highlighting the importance of DICER in warranting the beneficial effects of health-promoting interventions.
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ISSN:1867-2450
1867-2469
DOI:10.1007/s12551-021-00902-w